2020
The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms
Xiao C, Fedirko V, Beitler J, Bai J, Peng G, Zhou C, Gu J, Zhao H, Lin IH, Chico CE, Jeon S, Knobf TM, Conneely KN, Higgins K, Shin DM, Saba N, Miller A, Bruner D. The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms. Supportive Care In Cancer 2020, 29: 3173-3182. PMID: 33078326, PMCID: PMC8055716, DOI: 10.1007/s00520-020-05820-3.Peer-Reviewed Original ResearchConceptsCancer-related fatigueGut microbiomePilot studyHigh-fatigue groupLow-fatigue groupsGut-brain axisMultidimensional Fatigue InventoryGut microbiota patternBrain healthCancer patientsFatigue InventoryNeck cancerPurposeRecent evidenceStool samplesImmune responseMicrobiota patternsGut microbiotaInflammationOne monthBrain functionPatientsConclusionsOur resultsFatty acid synthesisEPIC BeadChipDNA methylation changesElevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors
Schalper KA, Carleton M, Zhou M, Chen T, Feng Y, Huang SP, Walsh AM, Baxi V, Pandya D, Baradet T, Locke D, Wu Q, Reilly TP, Phillips P, Nagineni V, Gianino N, Gu J, Zhao H, Perez-Gracia JL, Sanmamed MF, Melero I. Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors. Nature Medicine 2020, 26: 688-692. PMID: 32405062, PMCID: PMC8127102, DOI: 10.1038/s41591-020-0856-x.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntineoplastic Agents, ImmunologicalBiomarkers, PharmacologicalBiomarkers, TumorCell Cycle CheckpointsCohort StudiesFemaleHumansInterleukin-8MaleNeoplasmsNeutrophil InfiltrationNeutrophilsPrognosisProtein Kinase InhibitorsRetrospective StudiesSurvival AnalysisTreatment FailureTumor MicroenvironmentUp-RegulationConceptsSerum IL-8 levelsImmune checkpoint inhibitorsIL-8 levelsAdvanced cancerSerum interleukin-8 levelsPhase 3 clinical trialsSerum interleukin-8Interleukin-8 levelsLarge-scale retrospective analysisNeutrophil infiltrationWorse prognosisClinical benefitPoor outcomeIndependent biomarkerTumor immunobiologyClinical trialsInterleukin-8Retrospective analysisPatientsCancerInhibitorsIpilimumabNivolumabEverolimusPrognosis
2016
High-dimensional omics data analysis using a variable screening protocol with prior knowledge integration (SKI)
Liu C, Jiang J, Gu J, Yu Z, Wang T, Lu H. High-dimensional omics data analysis using a variable screening protocol with prior knowledge integration (SKI). BMC Systems Biology 2016, 10: 118. PMID: 28155690, PMCID: PMC5260139, DOI: 10.1186/s12918-016-0358-0.Peer-Reviewed Original ResearchConceptsHigh-throughput data analysisDifferent statistical methodsStatistical methodsOmics data analysisPrior knowledge integrationR packageData analysisMarginal correlationRankSame numberInitial rankThroughput analysisSample sizeHigh true positive rateDifferent datasetsSimulationsRaw dataSmall sample size
2015
Identification of cancer‐related genes and motifs in the human gene regulatory network
Carson M, Gu J, Yu G, Lu H. Identification of cancer‐related genes and motifs in the human gene regulatory network. IET Systems Biology 2015, 9: 128-134. PMID: 26243828, PMCID: PMC8687282, DOI: 10.1049/iet-syb.2014.0058.Peer-Reviewed Original Research