2010
T Cell LFA-1 Engagement Induces HuR-Dependent Cytokine mRNA Stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 Signaling Cascade
Ramgolam VS, DeGregorio SD, Rao GK, Collinge M, Subaran SS, Markovic-Plese S, Pardi R, Bender JR. T Cell LFA-1 Engagement Induces HuR-Dependent Cytokine mRNA Stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 Signaling Cascade. PLOS ONE 2010, 5: e14450. PMID: 21206905, PMCID: PMC3012057, DOI: 10.1371/journal.pone.0014450.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceCytokinesELAV ProteinsELAV-Like Protein 1GTP PhosphohydrolasesHumansIntegrinsInterferon-gammaLymphocyte Function-Associated Antigen-1MAP Kinase Kinase 3MiceMice, Inbred C57BLNeuropeptidesP38 Mitogen-Activated Protein KinasesProto-Oncogene Proteins c-vavRac GTP-Binding ProteinsRac1 GTP-Binding ProteinRNA-Binding ProteinsSignal TransductionT-LymphocytesTumor Necrosis Factor-alpha
2006
LFA-1-Dependent HuR Nuclear Export and Cytokine mRNA Stabilization in T Cell Activation
Wang JG, Collinge M, Ramgolam V, Ayalon O, Fan XC, Pardi R, Bender JR. LFA-1-Dependent HuR Nuclear Export and Cytokine mRNA Stabilization in T Cell Activation. The Journal Of Immunology 2006, 176: 2105-2113. PMID: 16455966, DOI: 10.4049/jimmunol.176.4.2105.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAntigens, SurfaceBase SequenceCD28 AntigensCell NucleusCells, CulturedCytokinesCytoplasmELAV ProteinsELAV-Like Protein 1HumansLymphocyte ActivationLymphocyte Function-Associated Antigen-1Molecular Sequence DataRNA StabilityRNA, MessengerRNA, Small InterferingRNA-Binding ProteinsT-LymphocytesConceptsNuclear exportAU-rich element (ARE) sequenceMRNA stabilizationClass II AU-rich elementsT cell activationAU-rich elementsLymphokine gene expressionRapid nuclearRegulated processIntegrin engagementCell activationMRNA reporterRNA interferenceHuR functionIntegrin LFA-1MRNA stabilityGene expressionProtein productionHuman peripheral T cellsCytoplasmic translocationGM-CSF mRNAElement sequencesProtein HuRHuR levelsLFA-1
2005
Cytokines and cardiovascular disease
Mehra VC, Ramgolam VS, Bender JR. Cytokines and cardiovascular disease. Journal Of Leukocyte Biology 2005, 78: 805-818. PMID: 16006537, DOI: 10.1189/jlb.0405182.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseMyocardial functionNitric oxideMyocardial depressant effectsProgression of atherosclerosisRole of cytokinesRelease of cytokinesArachidonic acid metabolitesInflammatory mechanismsHeart failureInflammatory cascadeDepressant effectCytokine influenceImmune cascadeAcid metabolitesCytokinesBiochemical effectsDiseaseCommon formAtherosclerosisChemokinesReviewPathogenesisProgressionComprehensive review
2000
Simvastatin Modulates Cytokine-Mediated Endothelial Cell Adhesion Molecule Induction: Involvement of an Inhibitory G Protein
Sadeghi M, Collinge M, Pardi R, Bender J. Simvastatin Modulates Cytokine-Mediated Endothelial Cell Adhesion Molecule Induction: Involvement of an Inhibitory G Protein. The Journal Of Immunology 2000, 165: 2712-2718. PMID: 10946302, DOI: 10.4049/jimmunol.165.5.2712.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicBiological TransportCell Adhesion MoleculesCells, CulturedCholesterolCytokinesDrug SynergismEndothelium, VascularE-SelectinGene Expression RegulationGTP-Binding Protein alpha Subunits, Gi-GoHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIntercellular Adhesion Molecule-1Interleukin-1NF-kappa BRNA, MessengerSignal TransductionSimvastatinSodium FluorideUmbilical VeinsVascular Cell Adhesion Molecule-1ConceptsEffect of simvastatinCytokine-induced expressionIL-1Endothelial CAMsEndothelial cell adhesion molecules E-selectinNF-kappaBProinflammatory cytokines IL-1Cell adhesion molecules E-selectinAdhesion molecules E-selectinPotent immune modulatorG protein activator NaFCytokines IL-1G protein-coupled pathwayInhibitory G proteinCytokine-mediated activationSelectin mRNA levelsBasal toneProinflammatory cytokinesGialpha proteinsImmune modulatorsTNF-alphaICAM-1Pertussis toxinE-selectinEndothelial response
1997
Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines
Blum M, Toninelli E, Anderson J, Balda M, Zhou J, O'Donnell L, Pardi R, Bender J. Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines. American Journal Of Physiology 1997, 273: h286-h294. PMID: 9249502, DOI: 10.1152/ajpheart.1997.273.1.h286.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthineActinsBucladesineCells, CulturedCytokinesCytoskeletonElectrophysiologyEndothelium, VascularHumansInfant, NewbornInterferon-gammaMaleMembrane PotentialsMembrane ProteinsMicrocirculationPhosphoproteinsSkinTight JunctionsTumor Necrosis Factor-alphaUmbilical VeinsZonula Occludens-1 ProteinConceptsTransmonolayer electrical resistanceSpecialized intercellular structuresTight junctionsF-actin cytoskeletonLarge vessel ECActin cytoskeletonEndothelial cell typesMicrovascular endothelial cellsCytoskeletal rearrangementsStriking fragmentationF-actinProtein distributionCytochalasin DCell typesIntercellular structuresBarrier regulationCytoskeletal alterationsConfocal microscopyMVEC monolayersZO-1Macromolecular fluxCentral roleEC permeabilityEndothelial cellsPrimary cultures
1994
Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses.
Bender JR, Sadeghi MM, Watson C, Pfau S, Pardi R. Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 3994-3998. PMID: 7513430, PMCID: PMC43709, DOI: 10.1073/pnas.91.9.3994.Peer-Reviewed Original Research
1993
Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture.
Petzelbauer P, Bender JR, Wilson J, Pober JS. Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture. The Journal Of Immunology 1993, 151: 5062-72. PMID: 7691964, DOI: 10.4049/jimmunol.151.9.5062.Peer-Reviewed Original ResearchConceptsVCAM-1 expressionDermal microvascular endothelial cellsSuperficial vascular plexusAdhesion molecule-1 expressionDeep vascular plexusMolecule-1 expressionIL-1IL-4Molecule expressionVascular bedAntigen expressionCD36 expressionEndothelial leukocyte adhesion molecule-1 expressionELAM-1Normal skinEndothelial cell antigen expressionCytokine responsivenessVascular cell adhesion molecule-1 expressionVascular plexusCapillary loopsCell adhesion molecule-1 expressionParticular vascular bedEndothelial leukocyte adhesion moleculeAdhesion molecule expressionSites of inflammation
1989
EVIDENCE THAT CYTOTOXIC LYMPHOCYTES ALTER AND TRAVERSE ALLOGENEIC ENDOTHELIAL CELL MONOLAYERS
BENDER J, PARDI R, KOSEK J, ENGLEMAN E. EVIDENCE THAT CYTOTOXIC LYMPHOCYTES ALTER AND TRAVERSE ALLOGENEIC ENDOTHELIAL CELL MONOLAYERS. Transplantation 1989, 47: 1047-1052. PMID: 2660343, DOI: 10.1097/00007890-198906000-00026.Peer-Reviewed Original ResearchConceptsAllogeneic endothelial cellsEndothelial cellsClass II major histocompatibility complex antigensMajor histocompatibility complex antigensLymphocyte-EC adhesionHistocompatibility complex antigensEC monolayersSame morphologic changesAllogeneic lymphocytesLymphocyte subsetsLymphocyte subpopulationsAutologous combinationsEndothelial cell monolayersSuch lymphocytesSurface phenotypeComplex antigensIntact EC monolayerRecombinant cytokinesMorphologic changesLymphocytesCell monolayersEC barrierFunctional consequencesCurrent findingsCellular interactions