2000
Nerve growth factor maintains potassium conductance after nerve injury in adult cutaneous afferent dorsal root ganglion neurons
Everill B, Kocsis J. Nerve growth factor maintains potassium conductance after nerve injury in adult cutaneous afferent dorsal root ganglion neurons. Neuroscience 2000, 100: 417-422. PMID: 11008179, PMCID: PMC2605351, DOI: 10.1016/s0306-4522(00)00263-3.Peer-Reviewed Original ResearchConceptsTransient A-currentNerve growth factorDorsal root ganglion neuronsK currentsNerve ligationGrowth factorA-currentGanglion neuronsSciatic nerveWhole-cell patch-clamp techniquePotassium conductanceDistal nerve segmentsAfferent cell bodiesMini-osmotic pumpsVoltage-dependent potassium conductancePatch-clamp techniqueTransient potassium currentAppropriate ion replacementNerve growth factor treatmentGrowth factor treatmentNerve injuryNerve crushNerve segmentsCutaneous afferentsControl neurons
1993
Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury
Utzschneider D, Bhisitkhul R, Kocsis J. Increased spike‐frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury. Muscle & Nerve 1993, 16: 958-963. PMID: 8355727, DOI: 10.1002/mus.880160912.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal root axonsNerve injuryDorsal rootsPotassium channel blockerAction potentialsSciatic nerveChannel blockersSpike adaptationSciatic nerve injuryPeripheral nerve injurySucrose gap chamberBrief tetanic stimulationDorsal root fibersWhole nerve recordingsSpike frequency adaptationTransection groupBurst dischargesTetanic stimulationNerve recordingsControl groupInjuryRoot fibersBurst responseNerve
1991
Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve
Gardon T, Kocsis J, Waxman S. Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve. Muscle & Nerve 1991, 14: 640-646. PMID: 1922170, DOI: 10.1002/mus.880140707.Peer-Reviewed Original ResearchConceptsCompound action potentialRat sciatic nerveNerve crushRegenerated axonsSciatic nerveRegenerated nervesInward rectificationIntra-axonal recording techniquesAdult rat sciatic nerveTEA-sensitive potassium channelsPotassium channelsRegenerated rat sciatic nerveSucrose gap recordingsSciatic nerve crushPeripheral nerve axonsWhole nerve recordingsIntra-axonal recordingsVoltage-sensitive sodium channelsCrush injuryNormal nervesSensitive relaxationRepetitive stimulationAfterhyperpolarizationGap recordingsNerve recordings
1990
Trophic influence of the distal nerve segment on GABAA receptor expression in axotomized adult sensory neurons
Bhisitkul R, Kocsis J, Gordon T, Waxman S. Trophic influence of the distal nerve segment on GABAA receptor expression in axotomized adult sensory neurons. Experimental Neurology 1990, 109: 273-278. PMID: 2170161, DOI: 10.1016/s0014-4886(05)80017-2.Peer-Reviewed Original ResearchConceptsDistal nerve segmentsGamma-aminobutyric acidNerve segmentsSciatic nerveReceptor expressionSensory neuronsTrophic supportGABAA receptor agonist muscimolDorsal root ganglion neuronsAxotomized sensory neuronsReactive Schwann cellsGABAA receptor expressionAdult sensory neuronsReceptor agonist muscimolExpression of receptorsPeripheral target tissuesGABA receptor expressionDorsal root fibersGABA receptor sensitivityEnd organ innervationPostoperative dayNerve crushNerve transectionCrush siteDistal stump
1988
Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability
Hiner B, Mauk M, Peroutka S, Kocsis J. Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability. Brain Research 1988, 461: 1-9. PMID: 2906267, DOI: 10.1016/0006-8993(88)90719-6.Peer-Reviewed Original ResearchConceptsCerebellar parallel fibersSerotonergic mechanismsNerve excitabilityFiber excitabilityAction potentialsSucrose gap recordingsEffects of serotoninNovel anxiolytic buspironeCompound action potentialDose-dependent reductionSchaffer collateral fibersParallel fibersAfferent fibersSciatic nerveReversible decrementsCollateral fibersAnxiolytic buspironeConduction velocityDPATIpsapironeGap recordingsBuspironeCerebellar neuronsAxonal responseExcitabilityDiminished dorsal root GABA sensitivity following chronic peripheral nerve injury
Kingery W, Fields R, Kocsis J. Diminished dorsal root GABA sensitivity following chronic peripheral nerve injury. Experimental Neurology 1988, 100: 478-490. PMID: 3366201, DOI: 10.1016/0014-4886(88)90033-7.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidPrimary afferent depolarizationDorsal rootsGABA sensitivityNerve lesionsSciatic nerveDorsal root compound action potentialsChronic peripheral nerve injurySciatic crush injurySciatic nerve lesionChronic pain syndromeLumbar dorsal rootsPeripheral nerve injuryPeripheral nerve lesionsPeripheral nerve transectionSucrose gap chamberCompound action potentialDorsal root fibersRat lumbar dorsal rootsDorsal root axotomyPain syndromeNerve injuryCrush injuryNerve transectionSciatic axotomy
1987
Physiological properties of regenerated rat sciatic nerve following lesions at different postnatal ages
Bowe C, Kocsis J, Waxman S, Hildebrand C. Physiological properties of regenerated rat sciatic nerve following lesions at different postnatal ages. Brain Research 1987, 34: 123-131. DOI: 10.1016/0165-3806(87)90201-x.Peer-Reviewed Original ResearchControl nervesPostnatal ageSciatic nerveRegenerated nervesRegenerated rat sciatic nerveFrequency-following abilityOlder postnatal ageSciatic crush lesionRegenerated sciatic nerveAge 3 weeksCompound action potentialDifferent postnatal agesRat sciatic nerveWhole-nerve responseMonths of ageRelative refractory periodCrush lesionPharmacological blockadeNerve responsesSlight prolongationNerveElectrophysiological propertiesAction potentialsRefractory periodOlder ageAxonal GABA receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve
Bhisitkul R, Villa J, Kocsis J. Axonal GABA receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve. Experimental Brain Research 1987, 66: 659-663. PMID: 3038587, DOI: 10.1007/bf00270698.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidVentral root fibersGABA receptorsRoot fibersSensory fibersPeripheral nervesSensory axonsRegenerated sensory axonsSucrose gap chamberPeripheral nerve fibersRat peripheral nerveDorsal root fibersMammalian peripheral nervesAgonist baclofenNerve crushDorsal rootsAgonist muscimolSciatic nerveNerve fibersRat peripheral nerve fibersNerveReceptorsMuscimolSelective presenceAxonsNodal spacing along regenerated axons following a crush lesion of the developing rat sciatic nerve
Hildebrand C, Mustafa G, Bowe C, Kocsis J. Nodal spacing along regenerated axons following a crush lesion of the developing rat sciatic nerve. Brain Research 1987, 32: 147-154. DOI: 10.1016/0165-3806(87)90148-9.Peer-Reviewed Original ResearchNodal spacing along regenerated axons following a crush lesion of the developing rat sciatic nerve.
Hildebrand C, Mustafa G, Bowe C, Kocsis J. Nodal spacing along regenerated axons following a crush lesion of the developing rat sciatic nerve. Brain Research 1987, 429: 147-54. PMID: 3567658, DOI: 10.1016/0165-3806(87)90148-9.Peer-Reviewed Original ResearchConceptsRat sciatic nerveSciatic nerveRegenerated nervesCrush lesionRegenerated rat sciatic nerveNewborn rat pupsSciatic nerve axonsPostnatal ageRegenerated axonsPostnatal eventsRat pupsNerveNerve axonsMyelin sheathL increaseAxonsWeeksBirthAgeLesionsMyelinationSignsRemodellingSuch signsLength growth
1986
Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine
Targ E, Kocsis J. Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine. Brain Research 1986, 363: 1-9. PMID: 3004637, DOI: 10.1016/0006-8993(86)90652-9.Peer-Reviewed Original ResearchConceptsAction potentialsSciatic nerveFrequency-following abilityMultiple spike dischargesSite of demyelinationCompound action potentialPotassium channel blockerRat sciatic nerveAction potential characteristicsVariety of abnormalitiesAbsolute refractory periodExcitability changesPharmacological blockadeSpontaneous firingDemyelinated axonsChannel blockersConduction slowingConduction blockSpike dischargesLesion siteRefractory periodExcitability propertiesClinical useAxonsPotassium channels
1985
Myelin sheath remodelling in regenerated rat sciatic nerve
Hildebrand C, Kocsis J, Berglund S, Waxman S. Myelin sheath remodelling in regenerated rat sciatic nerve. Brain Research 1985, 358: 163-170. PMID: 2416385, DOI: 10.1016/0006-8993(85)90960-6.Peer-Reviewed Original ResearchConceptsRat sciatic nerveSciatic nerveRegenerated nervesAdult rat sciatic nerveRegenerated rat sciatic nerveNormal control nervesLight microscopic examinationAction potential waveformCrush lesionMonths survivalNerve segmentsControl nervesSame nerveIndividual nervesNerve fibersNerveShort sheathMyelin layersMyelin sheathPotassium channelsMicroscopic examinationLigature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance
Waxman S, Kocsis J, Eng D. Ligature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance. Muscle & Nerve 1985, 8: 85-92. PMID: 2414652, DOI: 10.1002/mus.880080202.Peer-Reviewed Original ResearchConceptsAction potentialsRepetitive firingSingle stimulusPotassium channelsCompound action potentialRat sciatic nerveAction potential propertiesWhole-nerve responseAction potential characteristicsIntra-axonal recordingsAction potential waveformNerve segmentsSciatic nerveNerve responsesPeripheral nervesInjury siteMyelinated fibersLater spikesElectrophysiological observationsNerveRefractory periodFiring patternsPotassium conductancePotential waveformInitial spike
1984
Retrograde impulse activity and horseradish peroxidase tracig of nerve fibers entering neuroma studied in vitro
Kocsis J, Preston R, Targ E. Retrograde impulse activity and horseradish peroxidase tracig of nerve fibers entering neuroma studied in vitro. Experimental Neurology 1984, 85: 400-412. PMID: 6745381, DOI: 10.1016/0014-4886(84)90150-x.Peer-Reviewed Original Research
1983
Myelin protein metabolism in demyelination and remyelination in the sciatic nerve
Smith M, Kocsis J, Waxman S. Myelin protein metabolism in demyelination and remyelination in the sciatic nerve. Brain Research 1983, 270: 37-44. PMID: 6871715, DOI: 10.1016/0006-8993(83)90789-8.Peer-Reviewed Original ResearchConceptsMyelin proteinsControl nervesLPC injectionSciatic nerveRight sciatic nerveSeries of ratsLeft nerveSchwann cellsNerveStructural myelin proteinsLPC treatmentFirst weekTime pointsAmino acid incorporationProtein metabolismLabeled amino acidsAcid incorporationMyelinDaysInjectionLysophosphatidylcholineDemyelinationRemyelinationProteinRats