1991
Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve
Gardon T, Kocsis J, Waxman S. Tea‐sensitive potassium channels and inward rectification in regenerated rat sciatic nerve. Muscle & Nerve 1991, 14: 640-646. PMID: 1922170, DOI: 10.1002/mus.880140707.Peer-Reviewed Original ResearchConceptsCompound action potentialRat sciatic nerveNerve crushRegenerated axonsSciatic nerveRegenerated nervesInward rectificationIntra-axonal recording techniquesAdult rat sciatic nerveTEA-sensitive potassium channelsPotassium channelsRegenerated rat sciatic nerveSucrose gap recordingsSciatic nerve crushPeripheral nerve axonsWhole nerve recordingsIntra-axonal recordingsVoltage-sensitive sodium channelsCrush injuryNormal nervesSensitive relaxationRepetitive stimulationAfterhyperpolarizationGap recordingsNerve recordings
1986
Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine
Targ E, Kocsis J. Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine. Brain Research 1986, 363: 1-9. PMID: 3004637, DOI: 10.1016/0006-8993(86)90652-9.Peer-Reviewed Original ResearchConceptsAction potentialsSciatic nerveFrequency-following abilityMultiple spike dischargesSite of demyelinationCompound action potentialPotassium channel blockerRat sciatic nerveAction potential characteristicsVariety of abnormalitiesAbsolute refractory periodExcitability changesPharmacological blockadeSpontaneous firingDemyelinated axonsChannel blockersConduction slowingConduction blockSpike dischargesLesion siteRefractory periodExcitability propertiesClinical useAxonsPotassium channels
1985
Myelin sheath remodelling in regenerated rat sciatic nerve
Hildebrand C, Kocsis J, Berglund S, Waxman S. Myelin sheath remodelling in regenerated rat sciatic nerve. Brain Research 1985, 358: 163-170. PMID: 2416385, DOI: 10.1016/0006-8993(85)90960-6.Peer-Reviewed Original ResearchConceptsRat sciatic nerveSciatic nerveRegenerated nervesAdult rat sciatic nerveRegenerated rat sciatic nerveNormal control nervesLight microscopic examinationAction potential waveformCrush lesionMonths survivalNerve segmentsControl nervesSame nerveIndividual nervesNerve fibersNerveShort sheathMyelin layersMyelin sheathPotassium channelsMicroscopic examinationDifferences between mammalian ventral and dorsal spinal roots in response to blockade of potassium channels during maturation
Bowe C, Kocsis J, Waxman S. Differences between mammalian ventral and dorsal spinal roots in response to blockade of potassium channels during maturation. Proceedings Of The Royal Society B 1985, 224: 355-366. PMID: 2410932, DOI: 10.1098/rspb.1985.0037.Peer-Reviewed Original ResearchConceptsDorsal spinal rootsSensory fibersMammalian motorPotassium channelsSpinal rootsAction potentialsRoot fibersCompound action potentialSingle sensory fibresDorsal root fibersVentral root fibersClasses of axonsIndividual action potentialsPharmacological blockadeVentral rootsYoung rootsSensory axonsWhole nervePotassium conductanceAxon responsesCourse of maturationBlockadeAxonsRoots resultsDifferential sensitivityLigature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance
Waxman S, Kocsis J, Eng D. Ligature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance. Muscle & Nerve 1985, 8: 85-92. PMID: 2414652, DOI: 10.1002/mus.880080202.Peer-Reviewed Original ResearchConceptsAction potentialsRepetitive firingSingle stimulusPotassium channelsCompound action potentialRat sciatic nerveAction potential propertiesWhole-nerve responseAction potential characteristicsIntra-axonal recordingsAction potential waveformNerve segmentsSciatic nerveNerve responsesPeripheral nervesInjury siteMyelinated fibersLater spikesElectrophysiological observationsNerveRefractory periodFiring patternsPotassium conductancePotential waveformInitial spikeAminopyridine-sensitivity of spinal cord white matter studied in vitro
Kocsis J. Aminopyridine-sensitivity of spinal cord white matter studied in vitro. Experimental Brain Research 1985, 57: 620-624. PMID: 2984039, DOI: 10.1007/bf00237849.Peer-Reviewed Original ResearchConceptsCentral nervous system extensionSpinal cord white matterAction potential dischargeDorsal column axonsSucrose gap chamberCompound action potentialPeripheral nervous systemCord white matterVentral root fibersAction potential characteristicsSensory fibersDorsal columnsDorsal rootsSpinal cordNervous systemWhite matterAction potentialsPotential dischargeRoot fibersPotassium channelsCourse of maturationOcclusion experimentsAxonsPronounced increaseCord
1983
Long-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents
Kocsis J, Waxman S. Long-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents. Nature 1983, 304: 640-642. PMID: 6308475, DOI: 10.1038/304640a0.Peer-Reviewed Original ResearchConceptsNerve fibersPotassium channelsMyelinated peripheral nerve fibresAxon segmentsPeripheral nerve fibersAxon sproutsEndoneurial tubesNerve crushFunctional recoveryFunctional organizationMyelinated fibersAxon cylindersSchwann cellsBurst activityMyelinated axonsMammalian axonsAxonsPeripheral connectionsMembrane depolarizationBasement membraneK channelsRegenerated fibersAxon maturation
1982
Regenerating mammalian nerve fibres: changes in action potential waveform and firing characteristics following blockage of potassium conductance
Kocsis J, Waxman S, Hildebrand C, Ruiz J. Regenerating mammalian nerve fibres: changes in action potential waveform and firing characteristics following blockage of potassium conductance. Proceedings Of The Royal Society B 1982, 217: 77-87. PMID: 6131423, DOI: 10.1098/rspb.1982.0095.Peer-Reviewed Original ResearchConceptsRegenerating axonsNerve fibersFiring propertiesAction potentialsPotassium conductancePotassium channelsCompound action potentialSciatic nerve fibersEarly regenerating axonsAction potential waveformRat nerve fibresMammalian nerve fibresDemyelinated axonsMyelinated fibersExtracellular applicationAxonsRecording techniquesSingle stimulusFiring characteristicsPotential waveformPresent study