2024
Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia.
Yokoyama T, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Ukai R, Oka S, Kocsis J, Honmou O. Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia. Journal Of Neurosurgery 2024, 1-9. PMID: 39454218, DOI: 10.3171/2024.6.jns241111.Peer-Reviewed Original ResearchInfusion of mesenchymal stem cellsMiddle cerebral artery occlusionMiddle cerebral artery occlusion inductionMesenchymal stem cellsCorpus callosumSystemic infusion of mesenchymal stem cellsMultiple infusionsAcute phaseMesenchymal stem cell infusionCerebral ischemiaStem cellsMultiple intravenous infusionsRat model of cerebral ischemiaHigh-dose infusionPermanent middle cerebral artery occlusionIschemic lesion volumeModels of cerebral ischemiaCC thicknessRandomized clinical trialsCerebral artery occlusionNeural tractsAcute cerebral strokeFunctional recovery outcomesMRI diffusion tensor imagingMSC-3
2021
Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia.
Takemura M, Sasaki M, Kataoka-Sasaki Y, Kiyose R, Nagahama H, Oka S, Ukai R, Yokoyama T, Kocsis J, Ueba T, Honmou O. Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia. Journal Of Neurosurgery 2021, 137: 402-411. PMID: 34861644, DOI: 10.3171/2021.8.jns21687.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionInduction of MCAOCorpus callosumMesenchymal stem cellsChronic phaseMotor functionRat modelWeek 8Vehicle groupInterhemispheric connectionsAdministration of MSCsChronic cerebral ischemia modelNeural connectionsChronic stroke modelCerebral artery occlusionChronic cerebral ischemiaIschemic lesion volumeLong-term disabilityGreater functional improvementCerebral ischemia modelEnhanced functional recoveryAnti-neurofilament antibodiesDiffusion tensorSingle systemic infusionStem cells
1988
Presynaptic actions of carbachol and adenosine on corticostriatal synaptic transmission studied in vitro
Malenka R, Kocsis J. Presynaptic actions of carbachol and adenosine on corticostriatal synaptic transmission studied in vitro. Journal Of Neuroscience 1988, 8: 3750-3756. PMID: 2848109, PMCID: PMC6569613, DOI: 10.1523/jneurosci.08-10-03750.1988.Peer-Reviewed Original ResearchConceptsStriatal neuronsSynaptic transmissionCorticostriatal synaptic transmissionExcitatory amino acidsField potentialsNeostriatal slice preparationField potential responsesCorticostriatal afferentsCorticostriatal responsesCorticostriatal fibersPresynaptic actionPostsynaptic actionsStriatal neurotransmittersCalcium antagonistsCarbachol actionCortical afferentsAfferent fibersIntrinsic neuronsStriatal afferentsPutative neurotransmittersAdenosine actionSlice preparationCorpus callosumNeostriatal slicesAfferents
1983
Effects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum
Preston R, Waxman S, Kocsis J. Effects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum. Experimental Neurology 1983, 79: 808-820. PMID: 6825765, DOI: 10.1016/0014-4886(83)90044-4.Peer-Reviewed Original ResearchConceptsRat corpus callosumCallosal fibersCerebral axonsNerve fibersCorpus callosumMammalian peripheral nerve fibersNegative waveVoltage-dependent potassium currentsSecond negative waveNon-myelinated nerve fibresPeripheral nerve fibersField potentialsShort-latency wavesFirst negative waveCallosal stimulationPotassium blockersPotassium currentAction potentialsPeripheral fibersCallosumRecording electrodesMembrane repolarizationAxonsFunctional organizationComparable differences
1979
Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum Light-microscopic observations
Waxman S, Kocsis J, Nitta K. Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum Light-microscopic observations. Journal Of The Neurological Sciences 1979, 44: 45-53. PMID: 512691, DOI: 10.1016/0022-510x(79)90221-1.Peer-Reviewed Original Research