A functional retinoic acid response element (RARE) is present within the distal promoter of the rat gonadotropin-releasing hormone (GnRH) gene
Cho S, Chung J, Choe Y, Choi H, Kim H, Rhee K, Kim K. A functional retinoic acid response element (RARE) is present within the distal promoter of the rat gonadotropin-releasing hormone (GnRH) gene. Brain Research 2001, 87: 204-213. PMID: 11245923, DOI: 10.1016/s0169-328x(01)00021-3.Peer-Reviewed Original ResearchConceptsGT1-1 cellsTrans-RARetinoic acid response elementConsensus retinoic acid response elementGT1-1 neuronal cellsRat GnRH geneGonadotropin-releasing hormone releaseFunctional retinoic acid response elementRat GnRH promoterGnRH promoterCAMP response elementGnRH transcriptionGnRH geneRat hypothalamic fragmentsSpecific bindingGonadotropin-releasing hormone (GnRH) geneTrans retinoic acidRARbeta gene expressionResponse elementAcid response elementHypothalamic fragmentsHormone releaseNeuronal cellsGene expressionPutative repeats9-cis-Retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via proximal promoter region that is distinct from all-trans-retinoic acid response element
Cho S, Chung J, Han J, Lee B, Kim H, Rhee K, Kim K. 9-cis-Retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via proximal promoter region that is distinct from all-trans-retinoic acid response element. Brain Research 2001, 87: 214-222. PMID: 11245924, DOI: 10.1016/s0169-328x(01)00020-1.Peer-Reviewed Original ResearchMeSH KeywordsAlitretinoinAnimalsAntineoplastic AgentsCells, CulturedDose-Response Relationship, DrugGene Expression RegulationGonadotropin-Releasing HormoneLigandsPromoter Regions, GeneticRatsReceptors, Retinoic AcidRetinoid X ReceptorsRNA, MessengerTranscription FactorsTranscription, GeneticTransfectionTretinoinConceptsGT1-1 cellsRat GnRH promoterPromoter-driven luciferase activityRetinoid X receptorTrans-RAGnRH expressionGnRH transcriptionLuciferase activityImmortalized GnRH neuronsRXR beta expressionGnRH promoterVehicle-treated controlsGnRH mRNA levelsGonadotropin-releasing hormone gene transcriptionGnRH gene expressionGonadotropin-releasing hormone (GnRH) geneTime-related mannerGnRH promoter activityTrans retinoic acidGnRH gene transcriptionTime-dependent mannerGnRH neuronsPresent studyBeta expressionResponse element