1999
Hidden Mortality Attributable to Rocky Mountain Spotted Fever: Immunohistochemical Detection of Fatal, Serologically Unconfirmed Disease
Paddock C, Greer P, Ferebee T, Singleton J, McKechnie D, Treadwell T, Krebs J, Clarke M, Holman R, Olson J, Childs J, Zaki S. Hidden Mortality Attributable to Rocky Mountain Spotted Fever: Immunohistochemical Detection of Fatal, Serologically Unconfirmed Disease. The Journal Of Infectious Diseases 1999, 179: 1469-1476. PMID: 10228069, DOI: 10.1086/314776.Peer-Reviewed Original ResearchConceptsCase fatality ratioDiagnosis of RMSFIHC stainingRocky Mountain Spotted FeverLaboratory-confirmed casesAcute-phase seraTickborne infectionHidden mortalityIgM antibodiesDiagnostic titerPolymerase chain reactionIHC findingsPatient seraSerologic assaysImmunohistochemical stainingSpotted FeverImmunohistochemical detectionFatal diseasePatientsDisease controlIndirect immunofluorescenceNotifiable diseaseDiseaseUnderestimates of mortalityTissue samples
1998
Epidemiology of human rabies in the United States, 1980 to 1996.
Noah D, Drenzek C, Smith J, Krebs J, Orciari L, Shaddock J, Sanderlin D, Whitfield S, Fekadu M, Olson J, Rupprecht C, Childs J. Epidemiology of human rabies in the United States, 1980 to 1996. Annals Of Internal Medicine 1998, 128: 922-30. PMID: 9634432, DOI: 10.7326/0003-4819-128-11-199806010-00012.Peer-Reviewed Original ResearchConceptsPostexposure prophylaxisHuman rabiesAnimal bitesBat bitesRabies virus variantVirus variantsLaboratory-confirmed casesMedical personnelExposure historyDiagnostic laboratory testsLocal health authoritiesDiagnosis of rabiesRabies virus transmissionInfectious salivaInsignificant woundMost patientsClinical courseClinical featuresClinical presentationDefinite historyAntemortem diagnosisCase reportClinical differencesClinical signsDifferential diagnosis