2019
A Case Study of Two Rodent-Borne Viruses: Not Always the Same Old Suspects
Childs J, Klein S, Glass G. A Case Study of Two Rodent-Borne Viruses: Not Always the Same Old Suspects. Frontiers In Ecology And Evolution 2019, 7: 35. DOI: 10.3389/fevo.2019.00035.Peer-Reviewed Original ResearchLCMV infectionRodent-Borne VirusesSolid organ recipientsPrevalence of infectionHuman diseasesWild rodent reservoirsSevere congenital diseaseSporadic sheddingAcute human diseaseOrgan recipientsChronic infectionWild rodent hostsRodent hostsSeoul virusFatal diseaseSEOVCongenital diseaseGolden hamstersInfectionPet rodentsLaboratory workersDiseaseMiceGenus HantavirusHundreds of cases
2005
Human Monocytotropic Ehrlichiosis
Dawson J, Ewing S, Davidson W, Childs J, Little S, Standaert S. Human Monocytotropic Ehrlichiosis. 2005, 239-257. DOI: 10.1128/9781555816490.ch14.Peer-Reviewed Original ResearchHuman monocytotropic ehrlichiosisMonocytotropic ehrlichiosisMild self-limiting symptomsSelf-limiting symptomsNonspecific febrile illnessSpectrum of manifestationsSeasonality of transmissionTick-borne zoonosisFebrile illnessAsymptomatic infectionClinical recognitionHigh riskRickettsial infectionEpidemiological studiesEtiologic agentFatal diseaseLaboratory diagnosisZoonotic diseaseEhrlichia chaffeensisLone star tickE. chaffeensisInfectionDiseaseEhrlichiosisUnited States
2001
Analysis of Risk Factors for Fatal Rocky Mountain Spotted Fever: Evidence for Superiority of Tetracyclines for Therapy
Holman R, Paddock C, Curns A, Krebs J, McQuiston J, Childs J. Analysis of Risk Factors for Fatal Rocky Mountain Spotted Fever: Evidence for Superiority of Tetracyclines for Therapy. The Journal Of Infectious Diseases 2001, 184: 1437-1444. PMID: 11709786, DOI: 10.1086/324372.Peer-Reviewed Original ResearchConceptsRisk factorsFatal Rocky Mountain Spotted FeverRocky Mountain Spotted FeverOnset of symptomsCase fatality rateTetracycline-class antibioticsPrimary therapyClinical characteristicsOlder patientsAppropriate therapyRMSF casesNonfatal casesNational surveillanceHigh riskSpotted FeverPatientsEffective antibioticsTherapyDeathFeverAntibioticsTreatmentSymptomsFactorsDiseasePersistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato.
Castro M, Nicholson W, Kramer V, Childs J. Persistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato. American Journal Of Tropical Medicine And Hygiene 2001, 65: 261-7. PMID: 11693866, DOI: 10.4269/ajtmh.2001.65.261.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialArachnid VectorsBase SequenceBorrelia burgdorferiCaliforniaDisease ReservoirsDNA, BacterialEhrlichiaEhrlichiosisFemaleFluorescent Antibody Technique, IndirectHeat-Shock ProteinsHumansIxodesMaleMicePolymerase Chain ReactionRatsRodent DiseasesSeasonsSeroepidemiologic StudiesSigmodontinaeZoonosesConceptsPolymerase chain reaction testingGroESL heat shock operonPersistent infectionReaction testingRatsE. phagocytophilaLyme diseaseBorrelia burgdorferiMiceSeropositive animalsDusky-footed wood ratsPCRWood ratsSeroreversionSensu latoSeroconversionSeropositiveBiopsySerologySeroreactivityInfectionDiseaseBloodAdult Ixodes pacificus CooleySerumProspective Assessment of the Etiology of Acute Febrile Illness after a Tick Bite in Slovenia
Lotrič-Furlan S, Petrovec M, Avsic-Zupanc T, Nicholson W, Sumner J, Childs J, Strle F. Prospective Assessment of the Etiology of Acute Febrile Illness after a Tick Bite in Slovenia. Clinical Infectious Diseases 2001, 33: 503-510. PMID: 11462187, DOI: 10.1086/322586.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnimalsBites and StingsBorrelia burgdorferi GroupCohort StudiesEhrlichiaEhrlichia chaffeensisEhrlichiosisEncephalitis Viruses, Tick-BorneEncephalitis, Tick-BorneFemaleFeverHumansLyme DiseaseMaleMiddle AgedProspective StudiesSloveniaTick-Borne DiseasesTicksConceptsFebrile illnessTick biteEhrlichia phagocytophila infectionAcute febrile illnessTickborne diseasesEvidence of infectionBorrelia burgdorferi sensu latoMeningeal involvementProspective studyClinical criteriaBurgdorferi sensu latoTickborne encephalitisProspective assessmentPatientsLaboratory evidenceImportant causeBacterial infectionsIllnessLyme borreliosisInfectionDiseaseResidents of SloveniaEtiologyBiteEncephalitisFort Chaffee Revisited: The Epidemiology of Tick-Borne Rickettsial and Ehrlichial Diseases at a Natural Focus
McCall C, Curns A, Rotz L, Singleton J, Treadwell T, Comer J, Nicholson W, Olson J, Childs J. Fort Chaffee Revisited: The Epidemiology of Tick-Borne Rickettsial and Ehrlichial Diseases at a Natural Focus. Vector-Borne And Zoonotic Diseases 2001, 1: 119-127. PMID: 12653142, DOI: 10.1089/153036601316977723.Peer-Reviewed Original ResearchConceptsTick-borne pathogensSerum samplesRetrospective cohort studyDetectable antibody titersPrimary risk factorRisk of transmissionFort ChaffeeFever group rickettsiaeCompatible illnessReactive EIAsTick-borne diseaseCohort studyDoxycycline useAntibody titersRisk factorsTick biteEhrlichial diseasesGroup rickettsiaeDiseaseMore pathogensProbable diseaseSeropositivityIllnessEhrlichia speciesInfection
2000
Transmission of tick‐borne agents of disease by blood transfusion: a review of known and potential risks in the United States
McQuiston J, Childs J, Chamberland M, Tabor E, Diseases F. Transmission of tick‐borne agents of disease by blood transfusion: a review of known and potential risks in the United States. Transfusion 2000, 40: 274-284. PMID: 10738026, DOI: 10.1046/j.1537-2995.2000.40030274.x.Peer-Reviewed Original Research
1999
An outbreak of acute bartonellosis (Oroya fever) in the Urubamba region of Peru, 1998.
Ellis B, Rotz L, Leake J, Samalvides F, Bernable J, Ventura G, Padilla C, Villaseca P, Beati L, Regnery R, Childs J, Olson J, Carrillo C. An outbreak of acute bartonellosis (Oroya fever) in the Urubamba region of Peru, 1998. American Journal Of Tropical Medicine And Hygiene 1999, 61: 344-9. PMID: 10463692, DOI: 10.4269/ajtmh.1999.61.344.Peer-Reviewed Original ResearchHidden Mortality Attributable to Rocky Mountain Spotted Fever: Immunohistochemical Detection of Fatal, Serologically Unconfirmed Disease
Paddock C, Greer P, Ferebee T, Singleton J, McKechnie D, Treadwell T, Krebs J, Clarke M, Holman R, Olson J, Childs J, Zaki S. Hidden Mortality Attributable to Rocky Mountain Spotted Fever: Immunohistochemical Detection of Fatal, Serologically Unconfirmed Disease. The Journal Of Infectious Diseases 1999, 179: 1469-1476. PMID: 10228069, DOI: 10.1086/314776.Peer-Reviewed Original ResearchConceptsCase fatality ratioDiagnosis of RMSFIHC stainingRocky Mountain Spotted FeverLaboratory-confirmed casesAcute-phase seraTickborne infectionHidden mortalityIgM antibodiesDiagnostic titerPolymerase chain reactionIHC findingsPatient seraSerologic assaysImmunohistochemical stainingSpotted FeverImmunohistochemical detectionFatal diseasePatientsDisease controlIndirect immunofluorescenceNotifiable diseaseDiseaseUnderestimates of mortalityTissue samplesFamily Cluster of Rocky Mountain Spotted Fever
Jones T, Craig A, Paddock C, McKechnie D, Childs J, Zaki S, Schaffner W. Family Cluster of Rocky Mountain Spotted Fever. Clinical Infectious Diseases 1999, 28: 853-859. PMID: 10825050, DOI: 10.1086/515213.Peer-Reviewed Original ResearchLong-Term Studies of Hantavirus Reservoir Populations in the Southwestern United States: Rationale, Potential, and Methods - Volume 5, Number 1—February 1999 - Emerging Infectious Diseases journal - CDC
Mills J, Yates T, Ksiazek T, Peters C, Childs J. Long-Term Studies of Hantavirus Reservoir Populations in the Southwestern United States: Rationale, Potential, and Methods - Volume 5, Number 1—February 1999 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 1999, 5: 95-101. PMID: 10081676, PMCID: PMC2627686, DOI: 10.3201/eid0501.990111.Peer-Reviewed Original ResearchConceptsHantavirus pulmonary syndromeInfectious Diseases journal - CDCIncidence of infectionHuman hantavirus diseasePulmonary syndromeHantavirus diseaseHantavirus infectionHemorrhagic feverRenal syndromeDisease controlLong-term studiesHantavirus reservoir populationsZoonotic agentsPrevention measuresSyndromeTerm studiesUnited StatesInfectionDiseaseHPS outbreaksPreventionHuman riskRodent hostsHuman diseasesReservoir populations
1998
Human ehrlichiosis in central Europe.
Lotric-Furlan S, Petrovec M, Avsic-Zupanc T, Nicholson W, Sumner J, Childs J, Strle F. Human ehrlichiosis in central Europe. Wiener Klinische Wochenschrift 1998, 110: 894-7. PMID: 10048172.Peer-Reviewed Original ResearchConceptsFebrile illnessTick biteHGE agentPresence of infectionUniversity Medical CenterBlood smear examinationHuman granulocytic ehrlichiosis (HGE) agentEhrlichiosis casesAcute human diseaseClinical characteristicsAntibiotic therapyDisease coursePhysician awarenessProspective studyLaboratory findingsDifferential diagnosisMedical CenterSmear examinationHuman diseasesHuman ehrlichiosisNumber of casesPatientsHuman infectionsInfectious diseasesDisease
1997
Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis
Paddock C, Sumner J, Shore G, Bartley D, Elie R, McQuade J, Martin C, Goldsmith C, Childs J. Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis. Journal Of Clinical Microbiology 1997, 35: 2496-2502. PMID: 9316896, PMCID: PMC229999, DOI: 10.1128/jcm.35.10.2496-2502.1997.Peer-Reviewed Original ResearchConceptsE. chaffeensisDH82 cellsEhrlichia chaffeensisArkansas isolateGroESL heat shock operonFatal ehrlichiosisMechanisms of diseasePulmonary insufficiencyClinical presentationMarked thrombocytopeniaSevere diseaseEhrlichial infectionCharacteristic manifestationsPatientsDays postinoculationMolecular evaluationChaffeensisPrimary isolationRRNA gene sequencesDiseaseIsolatesSpecific associationNew isolatesGene sequencesProtein gene
1995
Cluster of five children with acute encephalopathy associated with cat-scratch disease in South Florida
NOAH D, BRESEE J, GORENSEK M, ROONEY J, CRESANTA J, REGNERY R, WONG J, DEL TORO J, OLSON J, CHILDS J. Cluster of five children with acute encephalopathy associated with cat-scratch disease in South Florida. The Pediatric Infectious Disease Journal 1995, 14: 866-869. PMID: 8584313, DOI: 10.1097/00006454-199510000-00009.Peer-Reviewed Original ResearchConceptsCat-scratch diseaseAcute encephalopathyEvaluation of childrenIndirect fluorescent antibodyRegional lymphadenopathyStatus epilepticusSingle hospitalEncephalopathy casesBartonella henselaeEncephalopathyB. henselaeFocal clustersCausative agentFluorescent antibodyStray catsDiseaseChildrenAntibodiesHenselaeHigher proportionCatsLymphadenopathyEpilepticusEncephalitisPatientsRodent-Borne Hemorrhagic Fever Viruses: A Special Risk for Mammalogists?
Childs J, Mills J, Glass G. Rodent-Borne Hemorrhagic Fever Viruses: A Special Risk for Mammalogists? Journal Of Mammalogy 1995, 76: 664-680. DOI: 10.2307/1382739.Peer-Reviewed Original ResearchHemorrhagic fever virusPersistent infectionPathophysiological consequencesSpecial riskSurvival of hostsDiseases of humansFever virusDiseaseZoonotic diseaseTransmission routesVirusUnrelated virusesInfectionRemarkable specializationMammalian hostsHuman diseasesVariable effectsRiskRodentsHumansRodent speciesUse of Bartonella Antigens for Serologic Diagnosis of Cat-scratch Disease at a National Referral Center
Dalton M, Robinson L, Cooper J, Regnery R, Olson J, Childs J. Use of Bartonella Antigens for Serologic Diagnosis of Cat-scratch Disease at a National Referral Center. JAMA Internal Medicine 1995, 155: 1670-1676. PMID: 7542443, DOI: 10.1001/archinte.1995.00430150164017.Peer-Reviewed Original ResearchConceptsCat-scratch diseaseIndirect fluorescent antibodySerum samplesB henselaeFluorescent antibodyNational referral centerStrict clinical definitionsUse of antigensReferral centerCat contactRegional adenopathyCat scratchClinical historyFourfold riseB quintanaBasis of causeClinical definitionClinical informationDiagnostic criteriaPatientsSerologic diagnosisDisease controlBartonella henselaeCat ageDisease
1994
Emergence of hantavirus disease in the USA and Europe
Childs J, Rollin P. Emergence of hantavirus disease in the USA and Europe. Current Opinion In Infectious Diseases 1994, 7: 220-224. DOI: 10.1097/00001432-199404000-00014.Peer-Reviewed Original ResearchWorldwide public health problemAcute pulmonary diseaseAcute renal failureHigh case fatality ratioCase fatality ratioPublic health problemRenal failurePulmonary diseaseHantavirus diseaseFatality ratioExplosive outbreaksImportant causeHealth problemsDiseaseZoonotic agentsHantavirusesFirst isolationOutbreakEnvironmental factorsImportant roleDomestic Cases of Hemorrhagic Fever with Renal Syndrome in the United States
Glass G, Watson A, LeDuc J, Childs J. Domestic Cases of Hemorrhagic Fever with Renal Syndrome in the United States. Nephron 1994, 68: 48-51. PMID: 7991040, DOI: 10.1159/000188086.Peer-Reviewed Original ResearchConceptsRenal diseaseHantaviral infectionsHemorrhagic feverRenal syndromeHypertensive renal diseasePersistent hypertensionLiver failureMild illnessClinical featuresSerologic studiesAcute diseaseSeoul virusInfectionDiseaseFeverSyndromeUnited StatesVirusFurther evidenceHypertensionNauseaVomitingPatientsIllnessDomestic cases
1993
Antibodies to Borrelia burgdorferi and tick salivary gland proteins in New Jersey outdoor workers.
Schwartz B, Goldstein M, Childs J. Antibodies to Borrelia burgdorferi and tick salivary gland proteins in New Jersey outdoor workers. American Journal Of Public Health 1993, 83: 1746-8. PMID: 8259808, PMCID: PMC1694949, DOI: 10.2105/ajph.83.12.1746.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntibodiesAntibodies, BacterialArachnid VectorsBorrelia burgdorferi GroupCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleFollow-Up StudiesHumansLyme DiseaseMaleNew JerseyOccupational DiseasesPrevalenceRisk FactorsSalivary Proteins and PeptidesSeroepidemiologic StudiesSurveys and QuestionnairesTicksWorkplaceConceptsOutdoor workersBorrelia burgdorferiCross-sectional studyB. burgdorferi infectionSecond cross-sectional studyEnzyme-linked immunosorbentLyme disease seroprevalenceAntibody seropositivitySalivary gland proteinsBurgdorferi infectionTick exposureHigh riskLyme diseaseDisease seroprevalenceAntibodiesBurgdorferiGland proteinsSeropositivitySeroprevalenceInfectionPrevalenceDiseaseImmunosorbentWorkersInfection with a Ratborne Hantavirus in US Residents Is Consistently Associated with Hypertensive Renal Disease
Glass G, Watson A, LeDuc J, Kelen G, Quinn T, Childs J. Infection with a Ratborne Hantavirus in US Residents Is Consistently Associated with Hypertensive Renal Disease. The Journal Of Infectious Diseases 1993, 167: 614-620. PMID: 8095060, DOI: 10.1093/infdis/167.3.614.Peer-Reviewed Original ResearchConceptsHypertensive renal diseaseEnd-stage renal diseaseRenal diseaseAntibody prevalenceHantavirus infectionReference groupRenal disease diagnosisRace-related differencesDialysis groupDialysis patientsRisk factorsInfectionDiseasePatientsProteinuriaUS residentsHantavirusesPrevalenceDiagnosisGroupAssociationDisease diagnosisSame patternHypertensionSeroprevalence