Molecular Actions of 1,25‐Dihydroxyvitamin D3 on Genes Involved in Calcium Homeostasis*
Pike JW, Zella LA, Meyer MB, Fretz JA, Kim S. Molecular Actions of 1,25‐Dihydroxyvitamin D3 on Genes Involved in Calcium Homeostasis*. Journal Of Bone And Mineral Research 2007, 22: v16-v19. PMID: 18290714, DOI: 10.1359/jbmr.07s207.Peer-Reviewed Original ResearchConceptsTranscriptional start siteRegulatory regionsExpression of TRPV6RANKL geneKey regulatory regionsVertebrate organismsNovel genesChromatin immunoprecipitationStart siteRegulatory elementsUpstream sequencesGene expressionEnhancer regionMolecular mechanismsHuman TRPV6Upstream regionGenesTRPV6 geneMolecular actionsMolecular techniquesPrimary regulatorMicroarray methodKbTRPV6ExpressionPerspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor
Pike JW, Meyer MB, Watanuki M, Kim S, Zella LA, Fretz JA, Yamazaki M, Shevde NK. Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor. The Journal Of Steroid Biochemistry And Molecular Biology 2007, 103: 389-395. PMID: 17223545, PMCID: PMC1868541, DOI: 10.1016/j.jsbmb.2006.12.050.Peer-Reviewed Original ResearchConceptsTarget genesBasal transcriptional machineryChromatin immunoprecipitation techniqueVitamin D receptorKey target genesExpression of genesAltered gene expressionTranscriptional machineryVertebrate organismsGene regulationSystemic signalsTranscriptional modulationRegulatory regionsDNA sitesGene locusGene expressionPromoter regionEnhancer regionGenesImmunoprecipitation techniquesRegulatory capabilitiesMaintenance of calciumModular natureExpressionNew insights