Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production
Chun H, Im H, Kang YJ, Kim Y, Shin JH, Won W, Lim J, Ju Y, Park YM, Kim S, Lee SE, Lee J, Woo J, Hwang Y, Cho H, Jo S, Park JH, Kim D, Kim DY, Seo JS, Gwag BJ, Kim YS, Park KD, Kaang BK, Cho H, Ryu H, Lee CJ. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production. Nature Neuroscience 2020, 23: 1555-1566. PMID: 33199896, DOI: 10.1038/s41593-020-00735-y.Peer-Reviewed Original ResearchConceptsReactive astrocytesAlzheimer's diseaseAPP/PS1 micePathogenesis of ADReactivity of astrocytesBrains of patientsAppropriate experimental modelsGlial activationPS1 miceAstrocytic reactivityBrain atrophyPathological featuresNeuronal deathMonoamine oxidase BPathological hallmarkAD modelPrecise molecular mechanismsAnimal modelsAstrocytesCognitive impairmentPathological contributionExperimental modelDiseaseOxidase BEventual deathAlterations of transcriptome signatures in head trauma-related neurodegenerative disorders
Cho H, Hyeon SJ, Shin JY, Alvarez VE, Stein TD, Lee J, Kowall NW, McKee AC, Ryu H, Seo JS. Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders. Scientific Reports 2020, 10: 8811. PMID: 32483284, PMCID: PMC7264177, DOI: 10.1038/s41598-020-65916-y.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseBlotting, WesternCell Adhesion MoleculesChronic Traumatic EncephalopathyCraniocerebral TraumaEndothelial CellsFemaleGene OntologyGene Regulatory NetworksHumansMaleMemoryMiddle AgedNerve Tissue ProteinsNeurogliaNeuronsReal-Time Polymerase Chain ReactionSequence Analysis, RNASynaptic TransmissionTemporal LobeTranscription, GeneticTranscriptomeConceptsProtein kinase AProtein kinase CQuantitative real-time PCRChronic traumatic encephalopathyCell adhesion moleculeSynaptotagmin-1Transcriptome signaturesGene co-expression network analysisCAM-related genesCo-expression network analysisAMPA receptor genesCalmodulin-dependent protein kinase IICalcium/calmodulin-dependent protein kinase IIUnique transcriptome signaturesTraumatic brain injuryProtein kinase IIAlzheimer's diseaseFunction-related genesKinase AMemory function-related genesKinase IISpecific pathological markersKinase CWestern blot analysisReal-time PCR