2020
Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders
Cho H, Hyeon SJ, Shin JY, Alvarez VE, Stein TD, Lee J, Kowall NW, McKee AC, Ryu H, Seo JS. Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders. Scientific Reports 2020, 10: 8811. PMID: 32483284, PMCID: PMC7264177, DOI: 10.1038/s41598-020-65916-y.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseBlotting, WesternCell Adhesion MoleculesChronic Traumatic EncephalopathyCraniocerebral TraumaEndothelial CellsFemaleGene OntologyGene Regulatory NetworksHumansMaleMemoryMiddle AgedNerve Tissue ProteinsNeurogliaNeuronsReal-Time Polymerase Chain ReactionSequence Analysis, RNASynaptic TransmissionTemporal LobeTranscription, GeneticTranscriptomeConceptsProtein kinase AProtein kinase CQuantitative real-time PCRChronic traumatic encephalopathyCell adhesion moleculeSynaptotagmin-1Transcriptome signaturesGene co-expression network analysisCAM-related genesCo-expression network analysisAMPA receptor genesCalmodulin-dependent protein kinase IICalcium/calmodulin-dependent protein kinase IIUnique transcriptome signaturesTraumatic brain injuryProtein kinase IIAlzheimer's diseaseFunction-related genesKinase AMemory function-related genesKinase IISpecific pathological markersKinase CWestern blot analysisReal-time PCR
2017
Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy
Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Experimental & Molecular Medicine 2017, 49: e333-e333. PMID: 28524178, PMCID: PMC5454448, DOI: 10.1038/emm.2017.56.Peer-Reviewed Original ResearchConceptsProtein phosphataseChronic traumatic encephalopathyProtein phosphatase expressionRNA sequencing analysisCalcium-signaling pathwayIntraneuronal tau aggregatesTranscriptome analysisNeuropathological featuresMAP kinaseAlzheimer's diseasePhosphatase expressionSequencing analysisDistinctive neuropathological featuresRepetitive head injuryPhosphatase activityPost-mortem brain tissueAltered expressionProgressive neurodegenerative disorderNovel therapeutic approachesCommon pathological mechanismCell linesTau aggregatesNeurodegenerative diseasesNeurodegenerative disordersTraumatic encephalopathy
2016
Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers
Yoo SK, Lee S, Kim SJ, Jee HG, Kim BA, Cho H, Song YS, Cho SW, Won JK, Shin JY, Park do J, Kim JI, Lee KE, Park YJ, Seo JS. Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers. PLOS Genetics 2016, 12: e1006239. PMID: 27494611, PMCID: PMC4975456, DOI: 10.1371/journal.pgen.1006239.Peer-Reviewed Original ResearchConceptsClassical papillary thyroid carcinomaFollicular thyroid carcinomaFollicular adenomaHistological featuresThyroid cancerMolecular subtypesThyroid carcinomaInvasive follicular thyroid carcinomaSimilar histological featuresPapillary thyroid cancerPapillary thyroid carcinomaFollicular thyroid neoplasmBenign follicular adenomaPAX8-PPARGIndolent behaviorPreoperative diagnosisNovel molecular subtypesFollicular variantTherapeutic approachesNRAS mutationsThyroid neoplasmsMIFTCUpregulation of genesBRAF-likeCarcinoma