2020
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production
Chun H, Im H, Kang YJ, Kim Y, Shin JH, Won W, Lim J, Ju Y, Park YM, Kim S, Lee SE, Lee J, Woo J, Hwang Y, Cho H, Jo S, Park JH, Kim D, Kim DY, Seo JS, Gwag BJ, Kim YS, Park KD, Kaang BK, Cho H, Ryu H, Lee CJ. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production. Nature Neuroscience 2020, 23: 1555-1566. PMID: 33199896, DOI: 10.1038/s41593-020-00735-y.Peer-Reviewed Original ResearchConceptsReactive astrocytesAlzheimer's diseaseAPP/PS1 micePathogenesis of ADReactivity of astrocytesBrains of patientsAppropriate experimental modelsGlial activationPS1 miceAstrocytic reactivityBrain atrophyPathological featuresNeuronal deathMonoamine oxidase BPathological hallmarkAD modelPrecise molecular mechanismsAnimal modelsAstrocytesCognitive impairmentPathological contributionExperimental modelDiseaseOxidase BEventual death
2017
Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy
Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Experimental & Molecular Medicine 2017, 49: e333-e333. PMID: 28524178, PMCID: PMC5454448, DOI: 10.1038/emm.2017.56.Peer-Reviewed Original ResearchConceptsProtein phosphataseChronic traumatic encephalopathyProtein phosphatase expressionRNA sequencing analysisCalcium-signaling pathwayIntraneuronal tau aggregatesTranscriptome analysisNeuropathological featuresMAP kinaseAlzheimer's diseasePhosphatase expressionSequencing analysisDistinctive neuropathological featuresRepetitive head injuryPhosphatase activityPost-mortem brain tissueAltered expressionProgressive neurodegenerative disorderNovel therapeutic approachesCommon pathological mechanismCell linesTau aggregatesNeurodegenerative diseasesNeurodegenerative disordersTraumatic encephalopathy