Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease
Lee MY, Lee J, Hyeon SJ, Cho H, Hwang YJ, Shin J, McKee AC, Kowall NW, Kim J, Stein TD, Hwang D, Ryu H. Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease. Aging Cell 2020, 19: e13153. PMID: 32419307, PMCID: PMC7294781, DOI: 10.1111/acel.13153.Peer-Reviewed Original ResearchConceptsGenome-wide ChIPMRNA sequence dataBiological network analysisHistone H3K9me3Heterochromatin remodelingEpigenetic modificationsAD postmortem brainsEpigenetic signaturesFunction-related genesH3K9me3Cell motilityHeterochromatin condensationEpigenetic alterationsEpigenomeEpigenome signaturesNeuronal differentiationAlzheimer's diseaseExpression levelsHeterochromatinIntegrated analysisPostmortem brainsMRNA expression levelsSporadic Alzheimer's diseaseNetwork analysisPotential role