Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers
Yoo SK, Lee S, Kim SJ, Jee HG, Kim BA, Cho H, Song YS, Cho SW, Won JK, Shin JY, Park do J, Kim JI, Lee KE, Park YJ, Seo JS. Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers. PLOS Genetics 2016, 12: e1006239. PMID: 27494611, PMCID: PMC4975456, DOI: 10.1371/journal.pgen.1006239.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAdultAgedCarcinomaCarcinoma, PapillaryFemaleGene Expression Regulation, NeoplasticHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedMutationNeoplasm ProteinsThyroid Cancer, PapillaryThyroid NeoplasmsTranscriptomeConceptsClassical papillary thyroid carcinomaFollicular thyroid carcinomaFollicular adenomaHistological featuresThyroid cancerMolecular subtypesThyroid carcinomaInvasive follicular thyroid carcinomaSimilar histological featuresPapillary thyroid cancerPapillary thyroid carcinomaFollicular thyroid neoplasmBenign follicular adenomaPAX8-PPARGIndolent behaviorPreoperative diagnosisNovel molecular subtypesFollicular variantTherapeutic approachesNRAS mutationsThyroid neoplasmsMIFTCUpregulation of genesBRAF-likeCarcinoma