2021
Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models
Woo J, Cho H, Seol Y, Kim SH, Park C, Yousefian-Jazi A, Hyeon SJ, Lee J, Ryu H. Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models. Antioxidants 2021, 10: 229. PMID: 33546471, PMCID: PMC7913624, DOI: 10.3390/antiox10020229.Peer-Reviewed Original ResearchOxidative stressMitochondrial functionMitochondrial dysfunctionAntioxidant therapeutic strategiesAmyotrophic lateral sclerosisNeuronal damageLateral sclerosisParkinson's diseaseTherapeutic strategiesNeuronal activitySubcellular eventsAlzheimer's diseaseBiochemical energyNeurodegenerative disordersLiving organismDiseaseHuntington's diseaseNeurodegenerationArt computational modelsMitochondriaDysfunctionBrainSclerosisStressOrganisms
2020
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production
Chun H, Im H, Kang YJ, Kim Y, Shin JH, Won W, Lim J, Ju Y, Park YM, Kim S, Lee SE, Lee J, Woo J, Hwang Y, Cho H, Jo S, Park JH, Kim D, Kim DY, Seo JS, Gwag BJ, Kim YS, Park KD, Kaang BK, Cho H, Ryu H, Lee CJ. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production. Nature Neuroscience 2020, 23: 1555-1566. PMID: 33199896, DOI: 10.1038/s41593-020-00735-y.Peer-Reviewed Original ResearchConceptsReactive astrocytesAlzheimer's diseaseAPP/PS1 micePathogenesis of ADReactivity of astrocytesBrains of patientsAppropriate experimental modelsGlial activationPS1 miceAstrocytic reactivityBrain atrophyPathological featuresNeuronal deathMonoamine oxidase BPathological hallmarkAD modelPrecise molecular mechanismsAnimal modelsAstrocytesCognitive impairmentPathological contributionExperimental modelDiseaseOxidase BEventual death