2018
2235 15N-Leucine transport across the blood brain barrier is significantly impaired in the glutamine synthetase-inhibited brain
Gruenbaum S, Dhaher R, Behar K, Zaveri H, Erfe M, Eid T. 2235 15N-Leucine transport across the blood brain barrier is significantly impaired in the glutamine synthetase-inhibited brain. Journal Of Clinical And Translational Science 2018, 2: 1-1. PMCID: PMC6808188, DOI: 10.1017/cts.2018.37.Peer-Reviewed Original ResearchIpsilateral hippocampusDentate gyrusAstroglial glutamine synthetaseMicrodialysis guide cannulaBlood-brain barrierImmune system dysfunctionRight dentate gyrusBilateral dentate gyrusL-type amino acid transporterBrief isoflurane anesthesiaArtificial extracellular fluidSignificant increaseGlutamine concentrationImportant therapeutic targetBilateral microdialysis probesAmino acid influxMethionine sulfoximineContralateral hippocampusLiver diseaseBrain ammoniaSynaptic glutamateBrain barrierSystem dysfunctionGuide cannulaIsoflurane anesthesia
2008
Interictal spikes on intracranial recording: Behavior, physiology, and implications
Spencer SS, Goncharova II, Duckrow RB, Novotny EJ, Zaveri HP. Interictal spikes on intracranial recording: Behavior, physiology, and implications. Epilepsia 2008, 49: 1881-1892. PMID: 18479398, DOI: 10.1111/j.1528-1167.2008.01641.x.Peer-Reviewed Original ResearchConceptsInterictal spikesAED withdrawalSeizure onsetSpike rateMedial temporal lobe seizuresAntiepileptic drug changesRefractory epileptic patientsTemporal lobe seizuresOnset seizuresDrug changesEpileptic patientsNeocortical locationsClinical meaningMedial temporalSeizuresIntracranial electrodesDays of recordingAED mechanismsIntracranial recordingsSignificant increaseAEDsPrevious reportsOnsetSpecific effectsWithdrawal