2024
Mapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositories
2022
High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter
McGrath H, Zaveri H, Collins E, Jafar T, Chishti O, Obaid S, Ksendzovsky A, Wu K, Papademetris X, Spencer D. High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter. Scientific Reports 2022, 12: 18778. PMID: 36335146, PMCID: PMC9637135, DOI: 10.1038/s41598-022-21543-3.Peer-Reviewed Original ResearchConceptsEpilepsy surgery cohortStandardized brain regionsBrain structure-function relationshipsSurgery cohortClinical usefulnessBrain metricsAnatomical locationBrain regionsBrain localizationCortical parcellationOwn unique benefitsIntracranial electroencephalographyAnatomical designationBrain anatomyHuman brain anatomyHuman brainBrain atlasBrain landmarksBrain atlasesParcellationMagnetic resonanceNearest centimeterAnatomical featuresAnatomyCortical localization
2021
Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain
Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain. Epilepsia 2021, 62: e88-e97. PMID: 33949690, PMCID: PMC11259155, DOI: 10.1111/epi.16920.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acids, Branched-ChainBrain ChemistryChildChild, PreschoolChromatography, High Pressure LiquidDrug Resistant EpilepsyElectrocorticographyElectroencephalographyEpilepsies, PartialExtracellular SpaceFemaleGlutamic AcidHumansIsoleucineMaleMicrodialysisMiddle AgedSeizuresTandem Mass SpectrometryYoung AdultConceptsSpontaneous seizuresDrug-resistant focal epilepsyExtracellular brain glutamateHuman epileptic brainBranched-chain amino acidsBranched chain amino acids valineRefractory epilepsyBrain microdialysisGlutamatergic neurotransmissionFocal epilepsySeizure onsetBrain glutamateEpileptic brainHuman patientsSeizuresBrain regionsDialysis samplesMammalian targetEpilepsyLiquid chromatography-tandem mass spectrometryBaselineBCAAIntracranial electroencephalographyChromatography-tandem mass spectrometryPatientsAstroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy
Sandhu MRS, Gruenbaum BF, Gruenbaum SE, Dhaher R, Deshpande K, Funaro MC, Lee TW, Zaveri HP, Eid T. Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy. Frontiers In Neurology 2021, 12: 665334. PMID: 33927688, PMCID: PMC8078591, DOI: 10.3389/fneur.2021.665334.Peer-Reviewed Original ResearchMesial temporal lobe epilepsyAstroglial glutamine synthetaseTemporal lobe epilepsyLobe epilepsyIntractable mesial temporal lobe epilepsyAstrocytic glutamine synthetaseDepressive-like featuresPathogenesis of epilepsyType of epilepsyDiscrete brain regionsNeocortical epilepsyHippocampal neuronsEpilepsyBrain regionsGlutamate-ammonia ligaseLaboratory animalsPathogenesisPossible roleExperimental inhibitionGlutamine synthetaseEnzyme glutamine synthetaseDysfunctionSeizuresAstrocytesSyndromeNetwork-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis
Dhaher R, Gruenbaum SE, Sandhu MRS, Ottestad-Hansen S, Tu N, Wang Y, Lee TW, Deshpande K, Spencer DD, Danbolt NC, Zaveri HP, Eid T. Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis. Neurology 2021, 96: e2261-e2271. PMID: 33722994, PMCID: PMC8166437, DOI: 10.1212/wnl.0000000000011846.Peer-Reviewed Original ResearchConceptsSpontaneous seizuresSeizure propagationSeizure focusMesial temporal lobe epilepsyExtracellular brain levelsTemporal lobe epilepsyExtracellular glutamate levelsRelevant rodent modelsGlutamine synthetase inhibitor methionine sulfoximineTransporter subtype 1Contralateral hippocampusLobe epilepsyBrain levelsBrain microdialysisExtracellular GABANeurotransmitter levelsSeizure initiationGlutamate levelsSeizure onsetEpilepsy networkRodent modelsSubtype 1EpileptogenesisHippocampusBrain regions
2019
The connectivity index: an effective metric for grading epileptogenicity.
Yan Q, Gaspard N, Zaveri HP, Blumenfeld H, Hirsch LJ, Spencer DD, Alkawadri R. The connectivity index: an effective metric for grading epileptogenicity. Journal Of Neurosurgery 2019, 133: 971-978. PMID: 31561212, DOI: 10.3171/2019.4.jns195.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationSeizure onset zoneSite of stimulationSOZ contactsIrritative zoneComprehensive Epilepsy CenterControl contactsStimulation current intensityHabitual aurasHabitual seizuresEpilepsy centersSeizure generationBrain sitesFrequency stimulationEpileptic activityElectrical stimulationOnset zonePatientsRecording contactsStimulation sessionsBrain regionsFunctional connectivityStimulationOutcome casesSeizures
2018
Expanding Brain–Computer Interfaces for Controlling Epilepsy Networks: Novel Thalamic Responsive Neurostimulation in Refractory Epilepsy
Gummadavelli A, Zaveri HP, Spencer DD, Gerrard JL. Expanding Brain–Computer Interfaces for Controlling Epilepsy Networks: Novel Thalamic Responsive Neurostimulation in Refractory Epilepsy. Frontiers In Neuroscience 2018, 12: 474. PMID: 30108472, PMCID: PMC6079216, DOI: 10.3389/fnins.2018.00474.Peer-Reviewed Original ResearchResponsive neurostimulationRefractory epilepsyThalamic nucleiComplex network disorderIntralaminar thalamic nucleiSubcortical brain structuresCortical onsetSeizure controlGeneralized epilepsySeizure networkSeizure onsetEpilepsy networkNeuromodulatory techniquesEpilepsyExcitatory eventsClinical treatmentBrain regionsBrain structuresSeizuresPotential targetIntracranial electroencephalographyNetwork disorderPatientsFeasible targetNeurostimulationT103. The connectivity index: A novel metric to grade epileptogenicity
Alkawadri R, Zaveri H, Gaspard N, Yan Q, Hirsch L, Spencer D. T103. The connectivity index: A novel metric to grade epileptogenicity. Clinical Neurophysiology 2018, 129: e42. DOI: 10.1016/j.clinph.2018.04.104.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationSeizure onset zoneSOZ contactsSite of stimulationCortical potentialsOnset zoneDuration of epilepsyEvoked cortical potentialsSingle-pulse stimulationPulse electrical stimulationStimulation current intensityMethods PatientsPartial seizuresResults FiftySeizure generationBrain sitesFrequency stimulationEpileptic activityIrritative zoneElectrical stimulationRecording contactsStimulation intensityStimulation sessionsBrain regionsStimulation siteThe roles of surgery and technology in understanding focal epilepsy and its comorbidities
Spencer DD, Gerrard JL, Zaveri HP. The roles of surgery and technology in understanding focal epilepsy and its comorbidities. The Lancet Neurology 2018, 17: 373-382. PMID: 29553383, DOI: 10.1016/s1474-4422(18)30031-0.Peer-Reviewed Original ResearchConceptsFocal epilepsyNeuropsychiatric disordersComplete seizure controlPoor postsurgical outcomeRole of surgeryRefractory focal epilepsyOnset areaComorbid neuropsychiatric disordersSeizure onset areaBehavioral seizuresSeizure controlSurgical outcomesPostsurgical outcomesEpileptogenic tissueEpilepsy networkHigh prevalenceStructural brain networksIndividualised therapyPatientsBrain regionsEpilepsyElectrophysiological recordingsIntracranial electrophysiological recordingsStructural MRIGold standard
2017
(Invited) Conjoint Measurement of Brain Electrophysiology and Neurochemistry
Zaveri H, Ganesh N, Goncharova I, Damisah E, Ong C, Perez E, Staib L, Hirsch L, Petroff O, Spencer D, Eid T. (Invited) Conjoint Measurement of Brain Electrophysiology and Neurochemistry. ECS Meeting Abstracts 2017, MA2017-02: 2329-2329. DOI: 10.1149/ma2017-02/55/2329.Peer-Reviewed Original ResearchInterictal EEG spikesBasal glutamateBrain excitabilityIntractable epilepsyEEG spikesBrain electrophysiologySpike rateBasal extracellular glutamate concentrationsIntracranial EEG monitoringExtracellular glutamate concentrationCo-localized measurementsPossible epilepsy surgeryBrain extracellular glutamateInterictal electroencephalographyMicrodialysis catheterEpilepsy surgeryExtracellular glutamateBrain neurochemistryDialysis probeNeurochemical basisEEG monitoringGlutamate concentrationBrain regionsEpilepsyPatientsNetwork evolution in mesial temporal lobe epilepsy revealed by diffusion tensor imaging
Wang H, Huang Y, Coman D, Munbodh R, Dhaher R, Zaveri HP, Hyder F, Eid T. Network evolution in mesial temporal lobe epilepsy revealed by diffusion tensor imaging. Epilepsia 2017, 58: 824-834. PMID: 28378878, PMCID: PMC5429866, DOI: 10.1111/epi.13731.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyDiffusion tensor imagingTemporal lobe epilepsyFractional anisotropyLobe epilepsyAstroglial glutamine synthetaseEntorhinal-hippocampal areaEpileptogenic hippocampal formationNumerous brain regionsMultiple brain areasBrain diffusion tensor imagingLater time pointsInfused ratsEpileptogenic processCorpus callosumEpileptogenesisHippocampal formationBrain areasImaging biomarkersEarly identificationBrain regionsRatsTensor imagingFA changesTime points
2008
Temporal distributions of seizure occurrence from various epileptogenic regions
Durazzo TS, Spencer SS, Duckrow RB, Novotny EJ, Spencer DD, Zaveri HP. Temporal distributions of seizure occurrence from various epileptogenic regions. Neurology 2008, 70: 1265-1271. PMID: 18391158, DOI: 10.1212/01.wnl.0000308938.84918.3f.Peer-Reviewed Original ResearchConceptsMesial temporal lobeSeizure occurrencePartial epilepsyTemporal lobeBrain regionsParietal seizuresSeizure distributionNeocortical temporal lobeParietal lobe seizuresTemporal lobe seizuresFrontal lobe seizuresConsecutive adult subjectsCortical brain regionsCircadian rhythmNeocortical temporalSurgical resectionTemporal seizuresIntracranial EEG recordingsEpileptogenic regionSeizuresAdult subjectsEpilepsyEndogenous circadian rhythmLobeEEG recordings