2006
Evaluation of Oral Rehydration Solution by Whole‐Gut Perfusion in Rats: Effect of Osmolarity, Sodium Concentration and Resistant Starch
Subramanya S, Ramakrishna BS, Binder HJ, Farthing MJ, Young GP. Evaluation of Oral Rehydration Solution by Whole‐Gut Perfusion in Rats: Effect of Osmolarity, Sodium Concentration and Resistant Starch. Journal Of Pediatric Gastroenterology And Nutrition 2006, 43: 568-575. PMID: 17130730, DOI: 10.1097/01.mpg.0000239998.43141.b2.Peer-Reviewed Original ResearchConceptsOsmolarity oral rehydration solutionGlucose-ORSOral rehydration solutionNet water absorptionRehydration solutionWhole-gut perfusionSmall bowel absorptionColonic fluid absorptionSeverity of diarrheaAmylase-resistant starchSteady-state perfusionEscherichia coli heat-stable enterotoxinColi heat-stable enterotoxinBowel perfusionBowel absorptionSevere diarrheaDifferent etiologiesHigher net absorptionSegmental perfusionWistar ratsHeat-stable enterotoxinClinical practiceNet secretionExperimental animalsPerfusion
1994
Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon
Rajendran V, Binder H. Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon. The Journal Of Membrane Biology 1994, 141: 51-58. PMID: 7966245, DOI: 10.1007/bf00232873.Peer-Reviewed Original ResearchConceptsRat distal colonFatty acid stimulationDistal colonShort-chain fatty acidsNa-H exchangeActive chloride absorptionHalf maximal inhibitory concentrationAcid stimulationApical membrane vesiclesChain fatty acidsChloride absorptionFatty acid exchangeCl- gradientInhibitory concentrationOutward Cl gradientButyrate concentrationExtravesicular ClColonCellular modelMembrane vesiclesFatty acidsStimulationFunctional NaDisulfonic acidCompelling evidence
1990
Aldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon
Turnamian S, Binder H. Aldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon. American Journal Of Physiology 1990, 258: g492-g498. PMID: 2138421, DOI: 10.1152/ajpgi.1990.258.3.g492.Peer-Reviewed Original ResearchConceptsDietary sodium depletionBody wt-1RU 28362Receptor-specific agonistsSodium depletionPotassium secretionProximal colonDay 1Glucocorticoid receptorWT-1Cl absorptionAdministration of spironolactoneActive potassium secretionRat proximal colonSecondary hyperaldosteronismContinuous infusionAldosteroneGlucocorticoid agonistAgonistsElectrolyte transportSecretionStimulationSignificant increaseInfusionColon
1982
Mechanism of potassium adaptation
Hayslett J, Binder H. Mechanism of potassium adaptation. American Journal Of Physiology 1982, 243: f103-f112. PMID: 7051849, DOI: 10.1152/ajprenal.1982.243.2.f103.Peer-Reviewed Original ResearchConceptsPotassium secretionPotassium adaptationChronic renal insufficiencyNa-K-ATPase activityAdministration of glucocorticoidsPotassium loadingNa-K-ATPaseTransepithelial potential differenceRenal insufficiencyPotassium excretionColonic mucosaExcretory loadDietary potassium loadingDistal nephronLarge intestinePotassium homeostasisDietary loadingElevated levelsPotassium pumpBasolateral portionEpitheliumCellular changesDistal portionSecretionBasolateral cell membrane