2004
Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum
Hoque KM, Rajendran VM, Binder HJ. Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum. AJP Gastrointestinal And Liver Physiology 2004, 288: g956-g963. PMID: 15618279, DOI: 10.1152/ajpgi.00441.2004.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAnimalsBariumCarbacholChloridesColforsinCyclic AMPDiarrheaEnterocytesIleumMaleMembrane GlycoproteinsMonosaccharide Transport ProteinsPotassium ChannelsRatsRats, Sprague-DawleySodiumSodium-Glucose Transporter 1Sodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2Time FactorsZincConceptsCl(-) secretionRat ileumNa absorptionK channel blockadeBumetanide-sensitive 86Rb uptakeK channelsPresence of ouabainHalf maximal inhibitory concentrationNa-K-ATPaseAcute diarrheaStool outputCAMP-induced Cl- secretionMucosal additionMuscle layerAnion secretionLucite chamberCotransport activitySecretionClamp methodInhibitory concentrationDiarrheaCyclic monophosphateIleumEfflux experimentsSerosal
1982
Mechanism of potassium adaptation
Hayslett J, Binder H. Mechanism of potassium adaptation. American Journal Of Physiology 1982, 243: f103-f112. PMID: 7051849, DOI: 10.1152/ajprenal.1982.243.2.f103.Peer-Reviewed Original ResearchConceptsPotassium secretionPotassium adaptationChronic renal insufficiencyNa-K-ATPase activityAdministration of glucocorticoidsPotassium loadingNa-K-ATPaseTransepithelial potential differenceRenal insufficiencyPotassium excretionColonic mucosaExcretory loadDietary potassium loadingDistal nephronLarge intestinePotassium homeostasisDietary loadingElevated levelsPotassium pumpBasolateral portionEpitheliumCellular changesDistal portionSecretionBasolateral cell membrane