2004
Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum
Hoque KM, Rajendran VM, Binder HJ. Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum. AJP Gastrointestinal And Liver Physiology 2004, 288: g956-g963. PMID: 15618279, DOI: 10.1152/ajpgi.00441.2004.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAnimalsBariumCarbacholChloridesColforsinCyclic AMPDiarrheaEnterocytesIleumMaleMembrane GlycoproteinsMonosaccharide Transport ProteinsPotassium ChannelsRatsRats, Sprague-DawleySodiumSodium-Glucose Transporter 1Sodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2Time FactorsZincConceptsCl(-) secretionRat ileumNa absorptionK channel blockadeBumetanide-sensitive 86Rb uptakeK channelsPresence of ouabainHalf maximal inhibitory concentrationNa-K-ATPaseAcute diarrheaStool outputCAMP-induced Cl- secretionMucosal additionMuscle layerAnion secretionLucite chamberCotransport activitySecretionClamp methodInhibitory concentrationDiarrheaCyclic monophosphateIleumEfflux experimentsSerosal
1993
Inhibition of VIP-stimulated ion transport by a novel Y-receptor phenotype in rabbit distal colon
Ballantyne G, Goldenring J, Fleming F, Rush S, Flint J, Fielding L, Binder H, Modlin I. Inhibition of VIP-stimulated ion transport by a novel Y-receptor phenotype in rabbit distal colon. American Journal Of Physiology 1993, 264: g848-g854. PMID: 8388641, DOI: 10.1152/ajpgi.1993.264.5.g848.Peer-Reviewed Original ResearchConceptsVIP-stimulated increasesPeptide YYNeuropeptide YPancreatic polypeptideRabbit distal colonDistal colonRabbit distal colonic mucosaBasal short-circuit currentTetrodotoxin-insensitive mechanismVasoactive intestinal polypeptideDistal colonic mucosaColonic secretionIntestinal polypeptideReceptor phenotypeColonic mucosaParacrine regulatorVIP stimulationUssing chambersTissue cAMPPotent inhibitionCl fluxCyclic monophosphateColonInhibitionStimulation