2024
Effects of 28-day nose-only inhalation of PCB52 (2,2′,5,5′-Tetrachlorobiphenyl) on the brain transcriptome
Bullert A, Wang H, Linahon M, Chimenti M, Adamcakova-Dodd A, Li X, Dailey M, Klingelhutz A, Ankrum J, Stevens H, Thorne P, Lehmler H. Effects of 28-day nose-only inhalation of PCB52 (2,2′,5,5′-Tetrachlorobiphenyl) on the brain transcriptome. Toxicology 2024, 509: 153965. PMID: 39369937, PMCID: PMC11588532, DOI: 10.1016/j.tox.2024.153965.Peer-Reviewed Original ResearchBehavior compared to controlsImpact locomotor activityFemale ratsPCB52 exposureNose-only inhalationWorking memoryBrains of femalesBehavioral effectsLocomotor activityMale Sprague-Dawley ratsMale ratsRat brainStriatumNeurobehavioral testsBrain transcriptomeCerebellar cortexSprague-Dawley ratsBrainConsecutive daysNo significant differenceImmunohistochemical evaluationRatsChromatography-tandem mass spectrometryTotal cellsSignificant difference16p11.2 Microdeletion Induces Sex-Specific Defects in Placental Development in Mice
Carver A, Kelvingtion B, Fairbairn F, Abel T, Stevens H. 16p11.2 Microdeletion Induces Sex-Specific Defects in Placental Development in Mice. Placenta 2024, 154: e16-e17. DOI: 10.1016/j.placenta.2024.07.101.Peer-Reviewed Original ResearchEffects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress
da Cunha Menezes E, de Abreu F, Davis J, Maurer S, Roshko V, Richardson A, Dowell J, Cassella S, Stevens H. Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress. Developmental Biology 2024, 515: 112-120. PMID: 39048051, PMCID: PMC11330572, DOI: 10.1016/j.ydbio.2024.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell MovementFemaleGABAergic NeuronsGene Expression Regulation, DevelopmentalGlutamate DecarboxylaseGlutathione PeroxidaseGlutathione Peroxidase GPX1HypothyroidismMaleMethimazoleMiceNF-E2-Related Factor 2Oxidative StressPlacentaPregnancyPrenatal Exposure Delayed EffectsThyroid HormonesConceptsGestational hypothyroidismGABAergic system developmentMaternal thyroid hormone supplyThyroid hormone supplyCortical GABAergic interneuronsMaternal thyroid hormonesGene expressionCD-1 miceCentral nervous system developmentEmbryonic day 9Central nervous systemIntrauterine restrictionGABAergic interneuronsGABAergic systemGPx1 gene expressionBrain gene expressionMouse brain developmentCD-1HypothyroidismEmbryonic dayNervous system developmentThyroid hormonesRisk factorsNeural system developmentHormonal imbalanceNarrative Review: A Neurobiological Perspective on Resilience in Youth
Khalid K, Baqir H, Stevens H. Narrative Review: A Neurobiological Perspective on Resilience in Youth. JAACAP Open 2024 DOI: 10.1016/j.jaacop.2024.05.001.Peer-Reviewed Original ResearchMental healthPsychiatric riskFamily history of depressionDevelopment of psychiatric morbidityHistory of depressionIntervention developmentWhite matter tractsNeurobiological underpinningsPsychiatric morbidityCingulate cortexPsychiatric resilienceNeuroimaging studiesPsychiatric symptomsNeurobiological perspectiveFamily historyResilience factorsYouth outcomesNarrative reviewDevelopmental overviewHealthInterventionIllnessYouthRiskGenetic perspectiveCorrelation of telomere length in brain tissue with peripheral tissues in living human subjects
Carver A, Hing B, Elser B, Lussier S, Yamanashi T, Howard M, Kawasaki H, Shinozaki G, Stevens H. Correlation of telomere length in brain tissue with peripheral tissues in living human subjects. Frontiers In Molecular Neuroscience 2024, 17: 1303974. PMID: 38516039, PMCID: PMC10954899, DOI: 10.3389/fnmol.2024.1303974.Peer-Reviewed Original ResearchCorrelation of telomere lengthPeripheral tissuesTissue telomere lengthTelomere lengthDisorder pathophysiologyAssessed telomere lengthBuccal telomere lengthBrain disordersHuman brainBrainIntractable epilepsyLiving human subjectsBrain samplesAverage telomere lengthTime pointsTissue samplesBrain tissueChromosome stabilityTissueHuman subjectsSalivaLiving subjectsSubjects
2023
Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2′,5,5′-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats
Wang H, Bullert A, Li X, Stevens H, Klingelhutz A, Ankrum J, Adamcakova-Dodd A, Thorne P, Lehmler H. Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2′,5,5′-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats. Toxicology 2023, 500: 153677. PMID: 37995827, PMCID: PMC10757425, DOI: 10.1016/j.tox.2023.153677.Peer-Reviewed Original ResearchConceptsPersistent organic pollutantsPolychlorinated biphenylsPolymeric implantsDrug delivery systemsPCB 52Tandem mass spectrometryOrganic pollutantsMass spectrometryGas chromatographySustained releaseDelivery systemHuman metabolitesHole-board testAdolescent Sprague DawleyMale adolescent ratsAnxiety-like behaviorOpen field testLoading concentrationStraightforward methodHydroxylated metabolitesSubacute neurotoxicitySubacute exposureImmune inhibitionNeurotoxic outcomesSprague-DawleyCommon Issues for General Practitioners in the Medical Management of Child and Adolescent Psychiatric Care.
Banerjee A, Johnson B, Kauer A, Gunderson C, Stevens H. Common Issues for General Practitioners in the Medical Management of Child and Adolescent Psychiatric Care. The Journal Of Pediatric Pharmacology And Therapeutics 2023, 28: 595-602. PMID: 38025144, PMCID: PMC10681082, DOI: 10.5863/1551-6776-28.7.595.Peer-Reviewed Original ResearchTreatment of attention deficit hyperactivity disorderAttention deficit hyperactivity disorderDeficit hyperactivity disorderAdolescent psychiatric careHyperactivity disorderAdolescent psychiatryPsychiatric problemsAdolescent psychiatristsPsychiatric careSleep problemsGeneral practitionersClinical pearlsMedical managementYouth patientsPractical guidanceYouthMedicationChildrenCommon issuesPsychiatrists
2022
3.87 The Neuroscience of Resilience in Youth: Review of Findings and Development of an Educational Module
Khalid K, Baqir H, Stevens H. 3.87 The Neuroscience of Resilience in Youth: Review of Findings and Development of an Educational Module. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 61: s256. DOI: 10.1016/j.jaac.2022.09.365.Peer-Reviewed Original Research
2017
Regulator of G‐protein signaling 6 (RGS6) expression in human substantia nigra pars compacta (SNc) and loss in Parkinson's disease (PD)
Luo Z, Ahlers K, Yang J, Chakravarti B, Stevens H, Narayanan N, Fisher R. Regulator of G‐protein signaling 6 (RGS6) expression in human substantia nigra pars compacta (SNc) and loss in Parkinson's disease (PD). The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.659.23.Peer-Reviewed Original ResearchSubstantia nigra pars compactaSNc DA neuronsDA neuronsParkinson's diseasePD patientsHuman substantia nigra pars compactaPotential novel therapeutic targetCritical neuroprotective roleDA neuron degenerationTyrosine hydroxylase expressionNovel therapeutic targetDevastating neurodegenerative disorderAge-dependent lossSNc neuronsMotor deficitsNeuroprotective rolePars compactaPathogenic linkNeuron degenerationPD treatmentDopamine neuronsHydroxylase expressionBehavioral deficitsDA contentImmunohistochemical analysisCross‐tissue telomere length measurement to determine auxiliary marker of brain telomere length in neurosurgery patients
Lussier S, Braun P, Potash J, Shinozaki G, Stevens H. Cross‐tissue telomere length measurement to determine auxiliary marker of brain telomere length in neurosurgery patients. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.lb60.Peer-Reviewed Original ResearchCentral nervous systemBlood telomere lengthCentral nervous system measuresNeurosurgery patientsTelomere lengthTelomere length measurementAcute time courseExposure to glucocorticoidsCoronary artery diseasePost-surgery samplesRisk of strokeResection surgeryArtery diseaseSynthetic glucocorticoidSamples of bloodLength measurementsExposure to stressRemoved tissueHeart diseaseHuman studiesAverage agePatientsPeripheral tissuesSurgeryPeripheral measures
2012
Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex
Stevens HE, Su T, Yanagawa Y, Vaccarino FM. Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex. Psychoneuroendocrinology 2012, 38: 509-521. PMID: 22910687, PMCID: PMC3532962, DOI: 10.1016/j.psyneuen.2012.07.011.Peer-Reviewed Original ResearchLearning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus
Stevens HE, Jiang GY, Schwartz ML, Vaccarino FM. Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus. Biological Psychiatry 2012, 71: 1090-1098. PMID: 22541947, PMCID: PMC3371339, DOI: 10.1016/j.biopsych.2012.03.013.Peer-Reviewed Original ResearchConceptsFGF receptor 2Fibroblast growth factorDentate gyrusReceptor 2Embryonic knockoutWater maze probe trialGrowth factor receptor 2Reference memoryFactor receptor 2Spatial reference memoryNeural stem cellsFibroblast growth factor receptor 2Immature neuronsCortical neuronsHippocampal volumeInducible knockout miceParvalbumin interneuronsShort-term learningGranule cellsKnockout miceSeparate cellular componentsHippocampusLong-term reference memoryAdult spatial memoryGrowth factor
2011
Induced pluripotent stem cells: A new tool to confront the challenge of neuropsychiatric disorders
Vaccarino FM, Stevens HE, Kocabas A, Palejev D, Szekely A, Grigorenko EL, Weissman S. Induced pluripotent stem cells: A new tool to confront the challenge of neuropsychiatric disorders. Neuropharmacology 2011, 60: 1355-1363. PMID: 21371482, PMCID: PMC3087494, DOI: 10.1016/j.neuropharm.2011.02.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInduced pluripotent stem cellsUse of iPSCsPluripotent stem cellsStem cellsEmbryonic stem cellsEarly developmental eventsMature somatic cellsEarly developmental stagesSomatic cellsGenetic variationGene productsDevelopmental eventsReprogramming strategiesNeural differentiationHuman brain developmentDevelopmental stagesIPSC technologyNeurodevelopmental pathwaysDevelopmental originsGenesPotential pharmacological interventionsNew toolGenetic deficitsCellsNeuropsychiatric disorders
2010
Fgfr2 Is Required for the Development of the Medial Prefrontal Cortex and Its Connections with Limbic Circuits
Stevens HE, Smith KM, Maragnoli ME, Fagel D, Borok E, Shanabrough M, Horvath TL, Vaccarino FM. Fgfr2 Is Required for the Development of the Medial Prefrontal Cortex and Its Connections with Limbic Circuits. Journal Of Neuroscience 2010, 30: 5590-5602. PMID: 20410112, PMCID: PMC2868832, DOI: 10.1523/jneurosci.5837-09.2010.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexCerebral cortexFibroblast growth factor receptorCKO miceExcitatory neuronsPrefrontal cortexCortical neuron developmentEntire cerebral cortexRadial glial cellsSpecific fibroblast growth factor receptorsGrowth factor receptorGABAergic neuronsLimbic circuitsCortical neuronsGlial cellsSubcortical stationsBed nucleusCortical developmentLimbic systemStria terminalisSynaptic terminalsSecondary decreaseNeuronal precursorsVentricular zoneNeuron developmentNeural Stem Cell Regulation, Fibroblast Growth Factors, and the Developmental Origins of Neuropsychiatric Disorders
Stevens HE, Smith KM, Rash BG, Vaccarino FM. Neural Stem Cell Regulation, Fibroblast Growth Factors, and the Developmental Origins of Neuropsychiatric Disorders. Frontiers In Neuroscience 2010, 4: 59. PMID: 20877431, PMCID: PMC2944667, DOI: 10.3389/fnins.2010.00059.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNeural stem cellsFibroblast growth factorGrowth factorPsychiatric disordersNeuropsychiatric disordersBrain-derived growth factorEmbryonic neural stem cellsNeural stem cell regulationStem cell regulationMajor depressionPsychiatric illnessAdult brainNeurodevelopmental underpinningsMental disordersNeuronal precursorsReceptor tyrosine kinasesCandidate susceptibility genesSchizophrenia 1DisordersHomeodomain genesMental retardationAbnormal specificationCell biologyDevelopmental originsMultipotent cells
2009
Risk and Resilience: Early Manipulation of Macaque Social Experience and Persistent Behavioral and Neurophysiological Outcomes
Stevens HE, Leckman JF, Coplan JD, Suomi SJ. Risk and Resilience: Early Manipulation of Macaque Social Experience and Persistent Behavioral and Neurophysiological Outcomes. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 114-127. PMID: 19127170, DOI: 10.1097/chi.0b013e318193064c.Peer-Reviewed Original ResearchAdolescentAdolescent BehaviorAnimalsChildChild BehaviorChild DevelopmentChild RearingChild, PreschoolGenotypeHumansInfantInfant, NewbornMacacaMother-Child RelationsNeurophysiologyNeurotransmitter AgentsResilience, PsychologicalRiskRisk FactorsSocial BehaviorSocial EnvironmentStress, PsychologicalTemperament