2023
Improving Adherence to Clinical Practice Guidelines for Managing Gastric Intestinal Metaplasia Among Gastroenterologists at a US Academic Institution
Jacob J, Millien V, Berger S, Hernaez R, Ketwaroo G, Flores A, Hou J, Jarbrink-Sehgal M, Khalaf N, Rosen D, El-Serag H, Tan M. Improving Adherence to Clinical Practice Guidelines for Managing Gastric Intestinal Metaplasia Among Gastroenterologists at a US Academic Institution. Journal Of Clinical Gastroenterology 2023, 58: 432-439. PMID: 37436841, PMCID: PMC10787041, DOI: 10.1097/mcg.0000000000001890.Peer-Reviewed Original ResearchH. pylori testingSurveillance endoscopyPreintervention cohortPostintervention studyBiopsy locationHigh-risk patientsClinical practice guidelinesGastric intestinal metaplasiaHelicobacter pylori testingPreintervention studyEndoscopic surveillanceIntestinal metaplasiaMapping biopsySurveillance recommendationsGastric mappingGIM patientsPostintervention cohortUS academic institutionsPractice guidelinesPatientsVA hospitalsClinical practiceUS hospitalsGastroenterologistsCohortBuilding a Quality Practice in Chronic Pancreatitis
Kothari D, Ketwaroo G, Sheth S. Building a Quality Practice in Chronic Pancreatitis. Journal Of Clinical Gastroenterology 2023, 57: 265-268. PMID: 36598825, DOI: 10.1097/mcg.0000000000001824.Peer-Reviewed Original ResearchConceptsChronic pancreatitisManagement of CPMyriad of symptomsChemical dependencyAbdominal painEndoscopic therapyPain managementIrreversible scarringFibroinflammatory disorderPancreatic parenchymaPatientsWeight lossPancreatitisCenters of excellenceNauseaSteatorrheaPainDiabetesScarringTherapySymptomsAvailable dataParenchymaRecent literature
2022
External validation of a model determining risk of neoplastic progression of Barrett’s esophagus in a cohort of U.S. veterans
Nguyen T, Thrift A, Ketwaroo G, Du X, Leon Novelo L, George R, Rosen D, El-Serag H. External validation of a model determining risk of neoplastic progression of Barrett’s esophagus in a cohort of U.S. veterans. Gastrointestinal Endoscopy 2022, 95: 1113-1122. PMID: 34998796, PMCID: PMC9119926, DOI: 10.1016/j.gie.2021.12.034.Peer-Reviewed Original ResearchConceptsHigh-grade dysplasiaHigh-risk groupEsophageal adenocarcinomaBarrett's esophagusBE patientsDiscriminatory abilityHouston Veterans Affairs Medical CenterVeterans Affairs Medical CenterHGD/esophageal adenocarcinomaRetrospective cohort studyExternal validationExternal validation studyInitial EGDCohort studyConsecutive patientsSmoking statusDysplasia statusRisk groupsMedical CenterHigh riskGeneral populationNew diagnosisPatientsClinical practiceBiopsy sampling
2021
S332 Determining the Profile of Patients Lost in Follow-up After the Resection of High-Risk Colonic Polyps
Jove A, Cifuentes J, Berger S, Caskey K, Kim H, Gacha M, Jarbrink-Sehgal M, Velez M, Hair C, Sealock R, Ketwaroo G. S332 Determining the Profile of Patients Lost in Follow-up After the Resection of High-Risk Colonic Polyps. The American Journal Of Gastroenterology 2021, 116: s144-s144. DOI: 10.14309/01.ajg.0000773800.52079.e4.Peer-Reviewed Original ResearchSa093 IMPROVING QUALITY OF CARE FOR PATIENTS WITH GASTROINTESTINAL BLEEDING DUE TO SMALL BOWEL ARTERIOVENOUS MALFORMATIONS
Szafron D, Chatterjee R, Bushan S, Ketwaroo G. Sa093 IMPROVING QUALITY OF CARE FOR PATIENTS WITH GASTROINTESTINAL BLEEDING DUE TO SMALL BOWEL ARTERIOVENOUS MALFORMATIONS. Gastroenterology 2021, 160: s-418. DOI: 10.1016/s0016-5085(21)01706-6.Peer-Reviewed Original ResearchPrevalence and Predictors of Missed Dysplasia on Index Barrett’s Esophagus Diagnosing Endoscopy in a Veteran Population
Nguyen T, Thrift A, George R, Rosen D, El-Serag H, Ketwaroo G. Prevalence and Predictors of Missed Dysplasia on Index Barrett’s Esophagus Diagnosing Endoscopy in a Veteran Population. Clinical Gastroenterology And Hepatology 2021, 20: e876-e889. PMID: 33839273, PMCID: PMC8900254, DOI: 10.1016/j.cgh.2021.04.008.Peer-Reviewed Original ResearchConceptsBarrett's esophagusIndex esophagogastroduodenoscopyIndefinite dysplasiaBE diagnosisLong-segment Barrett's esophagusProportion of patientsSegment Barrett's esophagusDysplastic Barrett's esophagusLogistic regression modelsBE lengthDefinite dysplasiaHouston VANDBE patientsClose followInitial biopsyDysplasia surveillanceBE patientsEndoscopic samplingRisk factorsOdds ratioEsophagogastroduodenoscopyRetrospective analysisPatientsVeteran populationDysplasia
2020
HP QI Abstract: Improving Helicobacter pylori Testing in Patients With Acute Upper GI Bleeding Due to Peptic Ulcer Disease
Bernica J, Cole R, Flores A, Hair C, Hernaez R, Hou J, Husain N, Jarbrink-Sehgal M, Kanwal F, Khalaf N, Natarajan Y, Tan M, Velez M, Ketwaroo G. HP QI Abstract: Improving Helicobacter pylori Testing in Patients With Acute Upper GI Bleeding Due to Peptic Ulcer Disease. Gastroenterology 2020, 159: e22-e23. DOI: 10.1053/j.gastro.2020.06.060.Peer-Reviewed Original Research538 IMPROVING HELICOBACTER PYLORI TESTING IN PATIENTS WITH ACUTE UPPER GI BLEEDING DUE TO PEPTIC ULCER DISEASE (POSTER PRESENTATION)
Bernica J, Cole R, Flores A, Hair C, Hernaez R, Hou J, Husain N, Jarbrink-Sehgal M, Kanwal F, Khalaf N, Natarajan Y, Tan M, Velez M, Ketwaroo G. 538 IMPROVING HELICOBACTER PYLORI TESTING IN PATIENTS WITH ACUTE UPPER GI BLEEDING DUE TO PEPTIC ULCER DISEASE (POSTER PRESENTATION). Gastroenterology 2020, 158: s-109. DOI: 10.1016/s0016-5085(20)30951-3.Peer-Reviewed Original Research
2019
Quality of Care Indicators in Patients with Acute Pancreatitis
Ketwaroo G, Sealock R, Freedman S, Hart P, Othman M, Wassef W, Banks P, Vege S, Gardner T, Yadav D, Sheth S, Kanwal F. Quality of Care Indicators in Patients with Acute Pancreatitis. Digestive Diseases And Sciences 2019, 64: 2514-2526. PMID: 31152333, DOI: 10.1007/s10620-019-05674-8.Peer-Reviewed Original ResearchConceptsExplicit quality indicatorsQuality of careCandidate quality indicatorsDetermination of etiologyCare of patientsDetermination of severityFuture quality improvementBackgroundAcute pancreatitisEndoscopic therapyFluid resuscitationSurgical managementRisk stratificationAcute pancreatitisCare indicatorsPatient outcomesQI setPatient carePatientsComprehensive literature reviewLiterature reviewQuality indicatorsExpensive conditionsStandardized techniqueProcess measuresCare
2017
The Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing
Kothari D, Ketwaroo G, Freedman S, Sheth S. The Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing. Pancreas 2017, 46: 887-890. PMID: 28697128, DOI: 10.1097/mpa.0000000000000871.Peer-Reviewed Original ResearchConceptsRecurrent acute pancreatitisPeak bicarbonate concentrationHistory of APAcute pancreatitisRisk factorsPancreatic function testingChronic pancreatitisLocal complicationsFunction testingFemale sexBicarbonate concentrationRetrospective reviewUnivariate analysisFamily historyTobacco usePancreatitisPatientsMultivariate analysisAlcohol useComplicationsSignificant differencesSexFactorsHistoryComparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis
Kothari D, Ketwaroo G, Sawhney M, Freedman S, Sheth S. Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis. Pancreas 2017, 46: 770-775. PMID: 28609365, DOI: 10.1097/mpa.0000000000000829.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersCross-Over StudiesEndoscopes, GastrointestinalEndoscopy, GastrointestinalEndosonographyFeasibility StudiesFemaleHumansMaleMiddle AgedPancreatic Function TestsPancreatic JuicePancreatitis, ChronicPredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsSecretinTime FactorsWorkflowConceptsChronic pancreatitisPeak bicarbonate concentrationPancreatic function testsEndoscopic ultrasonographyFunction testsPoor concordanceProspective crossover studyPancreatic function testingFunctional testsBicarbonate concentrationPeak bicarbonateSecretin testingCrossover studyFunction testingTest concordanceDiscordant findingsFunctional assessmentPatientsImproved concordancePancreatitisSignificant correlationUltrasonographyConcordanceFeasible testCutoff
2015
High Glasgow Blatchford Score at admission is associated with recurrent bleeding after discharge for patients hospitalized with upper gastrointestinal bleeding
Sengupta N, Tapper E, Patwardhan V, Ketwaroo G, Thaker A, Leffler D, Feuerstein J. High Glasgow Blatchford Score at admission is associated with recurrent bleeding after discharge for patients hospitalized with upper gastrointestinal bleeding. Endoscopy 2015, 48: 9-15. PMID: 26340604, DOI: 10.1055/s-0034-1392651.Peer-Reviewed Original ResearchConceptsGlasgow-Blatchford scoreUpper gastrointestinal bleedingGBS scoresBlatchford scoreGastrointestinal bleedingMultivariable analysisEndoscopic interventionHigh riskIntensive care unit admissionCare unit admissionMultivariable Cox regressionPost-discharge outcomesGBS patientsUnit admissionCause readmissionHospital deathRecurrent bleedingCohort studyReadmission ratesConsecutive patientsHospital readmissionSignificant morbidityCox regressionPatientsReadmissionRisk Factors for Adverse Outcomes in Patients Hospitalized With Lower Gastrointestinal Bleeding
Sengupta N, Tapper E, Patwardhan V, Ketwaroo G, Thaker A, Leffler D, Feuerstein J. Risk Factors for Adverse Outcomes in Patients Hospitalized With Lower Gastrointestinal Bleeding. Mayo Clinic Proceedings 2015, 90: 1021-1029. PMID: 26141075, PMCID: PMC4770256, DOI: 10.1016/j.mayocp.2015.04.024.Peer-Reviewed Original ResearchConceptsRecurrent lower gastrointestinal bleedingLower gastrointestinal bleedingCharlson Comorbidity Index scoreComorbidity Index scoreActive malignancyRisk factorsGastrointestinal bleedingAdverse outcomesMultivariable Cox proportional hazards regression modelsHigher Charlson Comorbidity Index scoresIndex scoreCox proportional hazards regression modelProportional hazards regression modelsBeth Israel Deaconess Medical CenterProspective observational studyHazards regression modelsAssociation of variablesRecurrent bleedingHospital dischargeConsecutive patientsHospital readmissionObservational studyMedical CenterMortality riskPatientsSalvage cryotherapy after failed radiofrequency ablation for Barrett’s esophagus–related dysplasia is safe and effective
Sengupta N, Ketwaroo G, Bak D, Kedar V, Chuttani R, Berzin T, Sawhney M, Pleskow D. Salvage cryotherapy after failed radiofrequency ablation for Barrett’s esophagus–related dysplasia is safe and effective. Gastrointestinal Endoscopy 2015, 82: 443-448. PMID: 25887715, DOI: 10.1016/j.gie.2015.01.033.Peer-Reviewed Original ResearchConceptsHigh-grade dysplasiaLow-grade dysplasiaRadiofrequency ablationIntramucosal carcinomaRecurrent dysplasiaEndoscopic therapyIntestinal metaplasiaBE dysplasiaEffective endoscopic therapyEradication of dysplasiaSafety of cryotherapyTertiary care centerBarrett's esophagus dysplasiaRFA sessionsSalvage cryotherapyCohort studySecondary outcomesHiatal herniaSingle centerInitial eradicationRetrospective natureEffective treatmentPatientsCryotherapyDysplasiaApproach to Patients With Suspected Chronic Pancreatitis
Ketwaroo G, Freedman S, Sheth S. Approach to Patients With Suspected Chronic Pancreatitis. Pancreas 2015, 44: 173-180. PMID: 25675419, DOI: 10.1097/mpa.0000000000000239.Peer-Reviewed Original ResearchConceptsChronic pancreatitisEarly diagnosisSignificant health care burdenSignificant health care resourcesNonspecific abdominal painEarly chronic pancreatitisHealth care burdenHealth care resourcesCurrent diagnostic testsAbdominal painPancreatic changesCare burdenLarge cohortCare resourcesPatientsDiagnostic testsDiagnosisPancreatitisAvailable literaturePainCohort
2014
Risks of Thromboembolism Versus Recurrent GI Hemorrhage After Interruption of Anticoagulation in Admitted Patients With GI Bleeding (GIB): A Prospective Study
Sengupta N, Feuerstein J, Patwardhan V, Ketwaroo G, Thaker A, Leffler D. Risks of Thromboembolism Versus Recurrent GI Hemorrhage After Interruption of Anticoagulation in Admitted Patients With GI Bleeding (GIB): A Prospective Study. The American Journal Of Gastroenterology 2014, 109: s668-s669. DOI: 10.14309/00000434-201410002-02293.Peer-Reviewed Original ResearchTu1335 Salvage Cryotherapy Is a Safe and Effective Therapy for Patients Who Have Persistent or Recurrent Dysplasia After Radiofrequency Ablation for Dysplastic Barrett's Esophagus
Ketwaroo G, Sengupta N, Sethi S, Tewani S, Dzeletovic I, Mosko J, Berzin T, Chuttani R, Sawhney M, Pleskow D. Tu1335 Salvage Cryotherapy Is a Safe and Effective Therapy for Patients Who Have Persistent or Recurrent Dysplasia After Radiofrequency Ablation for Dysplastic Barrett's Esophagus. Gastrointestinal Endoscopy 2014, 79: ab501-ab502. DOI: 10.1016/j.gie.2014.02.781.Peer-Reviewed Original Research
2013
Opioid-Induced Bowel Dysfunction
Ketwaroo G, Cheng V, Lembo A. Opioid-Induced Bowel Dysfunction. Current Gastroenterology Reports 2013, 15: 344. PMID: 23900996, PMCID: PMC5297124, DOI: 10.1007/s11894-013-0344-2.Peer-Reviewed Original ResearchConceptsBowel dysfunctionOpioid-Induced Bowel DysfunctionManagement of OICChronic opioid useEffective pharmacologic therapyGastrointestinal motility disordersQuality of lifeOpioid intakeOpioid usePharmacologic therapyChronic painMotility disordersMore painSuch medicationsWithdrawal symptomsSide effectsUnmet needOIBDPriority reviewDevelopment show promiseOpioidsPainPatientsDysfunctionOICDefining the Accuracy of Secretin Pancreatic Function Testing in Patients With Suspected Early Chronic Pancreatitis
Ketwaroo G, Brown A, Young B, Kheraj R, Sawhney M, Mortele K, Najarian R, Tewani S, Dasilva D, Freedman S, Sheth S. Defining the Accuracy of Secretin Pancreatic Function Testing in Patients With Suspected Early Chronic Pancreatitis. The American Journal Of Gastroenterology 2013, 108: 1360. PMID: 23711627, PMCID: PMC5388854, DOI: 10.1038/ajg.2013.148.Peer-Reviewed Original ResearchConceptsEarly chronic pancreatitisNegative predictive valueChronic pancreatitisPancreatic function testingPositive predictive valueHistologic evidenceFunction testingPredictive valuePancreatic imagingTertiary care institutionMedian followPositive patientsRetrospective reviewPancreatic functionMedical recordsPancreatitisPatientsDiagnostic accuracyCharacteristic symptomsCare institutionsFollowSubsequent developmentImagingEvidenceSymptoms
2012
Quality Improvement in Gastroenterology Clinical Practice
Kheraj R, Tewani S, Ketwaroo G, Leffler D. Quality Improvement in Gastroenterology Clinical Practice. Clinical Gastroenterology And Hepatology 2012, 10: 1305-1314. PMID: 22902758, PMCID: PMC5357135, DOI: 10.1016/j.cgh.2012.08.004.Peer-Reviewed Original ResearchConceptsChronic diseasesCommon gastrointestinal complaintsGastroenterology clinical practiceProcedure-related complicationsQI projectEvidence-based health careHigh-quality careGastroenterology careGastrointestinal complaintsOutpatient practiceGastrointestinal illnessClinical practiceGastrointestinal societiesGuidelines variesPatientsHealth careCareQuality improvementDiseaseGuidelinesComplicationsEndoscopyGastroenterologyIllnessManagement