2016
Issues in Trial Design and Areas Needing Further Research
Abraldes J, Salerno F, Augustin S, Ripoll C, Reiberger T, Moreau R, Albillos A, Garcia-Tsao G. Issues in Trial Design and Areas Needing Further Research. 2016, 355-363. DOI: 10.1007/978-3-319-23018-4_35.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPrimary end pointVariceal bleedingEnd pointTrial designAppropriate primary end pointVariceal bleeding episodesComplications of cirrhosisNew therapeutic approachesBleeding episodesMultiple complicationsTherapeutic trialsCase mortalityTherapeutic approachesHigh riskLower riskPatientsClinical scenariosComplicationsBleedingPrevious trialsCirrhosisSecond complicationMortalityTrialsDeath
2005
Bacterial translocation (BT) in cirrhosis
Wiest R, Garcia‐Tsao G. Bacterial translocation (BT) in cirrhosis. Hepatology 2005, 41: 422-433. PMID: 15723320, DOI: 10.1002/hep.20632.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsComplications of cirrhosisBacterial translocationPrevention of BTMucosal barrier functionAdaptive immune responsesPrevention of infectionNew therapeutic targetsImmunological defense mechanismsHuman cirrhosisIntestinal pathophysiologyCirrhosisImmune responseTherapeutic approachesIntestinal floraTherapeutic targetAnatomical sitesGut floraBarrier functionComplicationsMultiple mechanismsPathogenesisPreventionCurrent knowledgeDefense mechanismsAlterations