2022
Association of serum metabolites and gut microbiota at hospital admission with nosocomial infection development in patients with cirrhosis
Bajaj JS, Reddy KR, Tandon P, Garcia‐Tsao G, Kamath PS, O'Leary JG, Wong F, Lai J, Vargas H, Thuluvath PJ, Subramanian RM, Pena‐Rodriguez M, Sikaroodi M, Thacker LR, Gillevet PM. Association of serum metabolites and gut microbiota at hospital admission with nosocomial infection development in patients with cirrhosis. Liver Transplantation 2022, 28: 1831-1840. PMID: 36017804, PMCID: PMC11097235, DOI: 10.1002/lt.26552.Peer-Reviewed Original ResearchConceptsNosocomial infectionsGut microbiotaAnalysis of covariancePoor outcomeClinical variablesSerum metabolitesCommensal microbiotaNI developmentIntensive care unit transferHigh MELD scoreLiquid chromatography-mass spectrometry metabolomicsSpontaneous bacterial peritonitisCommon nosocomial infectionAdmission WBCHospital courseInpatient outcomesMELD scoreBacterial peritonitisHospital admissionOrgan failureStool microbiotaSerum metabolomicsStool samplesCirrhosisPatientsTHU494 Serum metabolites on admission associate with the development of nosocomial infections in inpatients with cirrhosis
Bajaj J, O’Leary J, Tandon P, Garcia-Tsao G, Kamath P, Thuluvath P, Subramanian R, Vargas H, McGeorge S, Fagan A, Wong F, Lai J, Thacker L, Reddy R. THU494 Serum metabolites on admission associate with the development of nosocomial infections in inpatients with cirrhosis. Journal Of Hepatology 2022, 77: s339-s340. DOI: 10.1016/s0168-8278(22)01041-8.Peer-Reviewed Original Research82: SERUM METABOLITES ON ADMISSION ASSOCIATE WITH OCCURRENCE OF NOSOCOMIAL INFECTIONS IN HOSPITALIZED PATIENTS WITH CIRRHOSIS
Bajaj J, O'Leary J, Tandon P, Garcia-Tsao G, Kamath P, Thuluvath P, Subramanian R, Lai J, Vargas H, Mcgeorge S, Fagan A, Wong F, Thacker L, Reddy K. 82: SERUM METABOLITES ON ADMISSION ASSOCIATE WITH OCCURRENCE OF NOSOCOMIAL INFECTIONS IN HOSPITALIZED PATIENTS WITH CIRRHOSIS. Gastroenterology 2022, 162: s-1114. DOI: 10.1016/s0016-5085(22)62677-5.Peer-Reviewed Original Research
2021
Admission Urinary and Serum Metabolites Predict Renal Outcomes in Hospitalized Patients With Cirrhosis
Bajaj JS, Garcia‐Tsao G, Reddy KR, O’Leary J, Vargas HE, Lai JC, Kamath PS, Tandon P, Subramanian RM, Thuluvath P, Fagan A, Sehrawat T, de la Rosa Rodriguez R, Thacker LR, Wong F. Admission Urinary and Serum Metabolites Predict Renal Outcomes in Hospitalized Patients With Cirrhosis. Hepatology 2021, 74: 2699-2713. PMID: 34002868, PMCID: PMC9338693, DOI: 10.1002/hep.31907.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPrediction of AKIClinical variablesSerum/urineSerum metabolitesBranched-chain amino acid metabolitesLiver disease centerNorth American ConsortiumRole of serumAmino acid metabolitesAdmission urinaryAKI developmentAKI subgroupCirrhosis cohortRenal outcomesRenoprotective measuresKidney injuryAKI predictionCirrhosis severityDialysis initiationHospitalized patientsPoor prognosisUrine metabolomicsEarly initiationSpecific admission431 SPECIFIC URINARY AND SERUM METABOLITES ON ADMISSION PREDICT THE DEVELOPMENT OF AKI AND NEED FOR DIALYSIS IN HOSPITALIZED PATIENTS WITH CIRRHOSIS
Bajaj J, Garcia-Tsao G, Reddy R, O'Leary J, Vargas H, Lai J, Kamath P, Tandon P, Subramanian R, Thuluvath P, Fagan A, Sehrawat T, De La Rosa-Rodriguez R, Wong F. 431 SPECIFIC URINARY AND SERUM METABOLITES ON ADMISSION PREDICT THE DEVELOPMENT OF AKI AND NEED FOR DIALYSIS IN HOSPITALIZED PATIENTS WITH CIRRHOSIS. Gastroenterology 2021, 160: s-775-s-776. DOI: 10.1016/s0016-5085(21)02565-8.Peer-Reviewed Original Research
2020
Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute-on-Chronic Liver Failure and Death in Patients With Cirrhosis
Bajaj JS, Reddy KR, O'Leary JG, Vargas HE, Lai JC, Kamath PS, Tandon P, Wong F, Subramanian RM, Thuluvath P, Fagan A, White MB, Gavis EA, Sehrawat T, de la Rosa Rodriguez R, Thacker LR, Sikaroodi M, Garcia-Tsao G, Gillevet PM. Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute-on-Chronic Liver Failure and Death in Patients With Cirrhosis. Gastroenterology 2020, 159: 1715-1730.e12. PMID: 32687928, PMCID: PMC7680282, DOI: 10.1053/j.gastro.2020.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAcute-On-Chronic Liver FailureAdultAgedBacteriaBiomarkersDatabases, FactualFecesFemaleGastrointestinal MicrobiomeHospital MortalityHumansLipidomicsLipidsLiver CirrhosisMaleMetabolomicsMiddle AgedNorth AmericaPatient AdmissionPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsTime FactorsConceptsDevelopment of ACLFSerum levelsClinical parametersStool samplesSerum metabolitesEnd-stage liver diseaseWhite blood cell countSerum samplesFecal microbiomeTertiary hepatology centersChronic liver failureDay of admissionMultiple centersTime of admissionBlood cell countNorth American ConsortiumLevels of phospholipidsMetabolomic analysisHepatology centersHospital admissionLiver failureClinical featuresLiver diseaseACLFEstrogen metabolites