2017
UV‐induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model
Wang J, Perry CJ, Meeth K, Thakral D, Damsky W, Micevic G, Kaech S, Blenman K, Bosenberg M. UV‐induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. Pigment Cell & Melanoma Research 2017, 30: 428-435. PMID: 28379630, PMCID: PMC5820096, DOI: 10.1111/pcmr.12591.Peer-Reviewed Original ResearchConceptsHigh somatic mutation burdenSomatic mutation burdenT cellsMutation burdenAnti-PD-1 therapyFunctional T cell responsesImmune checkpoint inhibitionAntitumor immune responseCD8 T cellsT cell responsesMouse melanoma modelCell numberSomatic mutationsMouse melanoma cell lineMelanoma cell linesTumor challengeAntitumor responseCheckpoint inhibitionImmune responseMelanoma modelHigh dosesImmune systemCell responsesMelanomas exhibitTumors
2016
Stereotactic Ablative Radiation Therapy Combined With Immunotherapy for Solid Tumors
Brooks ED, Schoenhals JE, Tang C, Micevic G, Gomez DR, Chang JY, Welsh JW. Stereotactic Ablative Radiation Therapy Combined With Immunotherapy for Solid Tumors. The Cancer Journal 2016, 22: 257-266. PMID: 27441745, PMCID: PMC5812885, DOI: 10.1097/ppo.0000000000000210.Peer-Reviewed Original ResearchConceptsStereotactic ablative radiation therapyImmune checkpoint therapyAblative radiation therapyRadiation therapyNovel therapeuticsImmune checkpoint inhibitionImmune checkpoint inhibitorsLocal treatment optionsEncouraging clinical responsesClinical responseExperience relapseSystemic therapyTreatment optionsClinical studiesLocal irradiationSystemic effectsImmunogenic effectsImmunotherapySolid tumorsTherapyNumerous cancersTumorsTherapeuticsRelapsePatients