2022
Spinal cord protection in open and endovascular approaches to thoracoabdominal aortic aneurysms
Amabile A, Lewis E, Costa V, Tadros RO, Han DK, Di Luozzo G. Spinal cord protection in open and endovascular approaches to thoracoabdominal aortic aneurysms. Vascular 2022, 31: 874-883. PMID: 35507464, DOI: 10.1177/17085381221094411.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryAortic aneurysmSpinal cordDistal aortic perfusionSubclavian artery revascularizationSpinal cord protectionThoracoabdominal aortic aneurysmsCerebrospinal fluid drainageThoracic aortic aneurysmArtery revascularizationAortic repairEndovascular repairAortic perfusionAortic proceduresEndovascular approachSystemic hypothermiaPostoperative managementExtracorporeal circulationLocal edemaPersistent complicationsFluid drainageCurrent evidenceInjuryAdjunct
2019
“Crab‐like” mitral valve endocarditis
Amabile A, Williams EE, Di Luozzo G, Balaram SK. “Crab‐like” mitral valve endocarditis. Journal Of Cardiac Surgery 2019, 35: 425-426. PMID: 31816121, DOI: 10.1111/jocs.14368.Peer-Reviewed Original ResearchParaspinous muscle gene expression profiling following simulated staged endovascular repair of thoracoabdominal aortic aneurysm: exploring potential therapeutic pathways
Lewis ER, Geisbüsch S, Chang YJ, Costa V, Husain S, Soteropoulos P, Griepp RB, Di Luozzo G. Paraspinous muscle gene expression profiling following simulated staged endovascular repair of thoracoabdominal aortic aneurysm: exploring potential therapeutic pathways. European Journal Of Cardio-Thoracic Surgery 2019, 57: 30-38. PMID: 31006003, DOI: 10.1093/ejcts/ezz113.Peer-Reviewed Original ResearchConceptsAneurysm repairGene expression profilingCollateral networkThoracoabdominal aortic aneurysm repairSpinal collateral networkSpinal segmental arteriesSuch extensive proceduresThoracoabdominal aortic aneurysmsAortic aneurysm repairSpinal cord perfusionSpinal cord injuryPotential therapeutic pathwayExpression profilingArteriolar remodellingTAAA repairCord perfusionNeurological complicationsEndovascular repairNeuroprotective effectsEndovascular techniquesCord injuryAortic aneurysmCoil embolizationEndovascular coilingEndovascular intervention
2013
Hypothermia for aortic surgery
Griepp RB, Di Luozzo G. Hypothermia for aortic surgery. Journal Of Thoracic And Cardiovascular Surgery 2013, 145: s56-s58. PMID: 23410782, DOI: 10.1016/j.jtcvs.2012.11.072.Peer-Reviewed Original ResearchConceptsHypothermic circulatory arrestCirculatory arrestAcceptable neurologic outcomesAortic arch repairThoracoabdominal aortic aneurysmsAortic surgeryNeurologic outcomeArch repairSurgical patientsBrain metabolismOrgan protectionAortic aneurysmDeep hypothermiaClinical practicePig modelRoutine useHypothermiaArrestRepairPatientsSurgeryAneurysmsPerfusion
2012
Visceral and spinal cord protection during thoracoabdominal aortic aneurysm repair: Clinical and laboratory update
Di Luozzo G. Visceral and spinal cord protection during thoracoabdominal aortic aneurysm repair: Clinical and laboratory update. Journal Of Thoracic And Cardiovascular Surgery 2012, 145: s135-s138. PMID: 23260453, DOI: 10.1016/j.jtcvs.2012.11.053.Peer-Reviewed Original ResearchOpen Repair of Descending and Thoracoabdominal Aortic Aneurysms and Dissections in Patients Aged Younger Than 60 Years: Superior to Endovascular Repair?
Di Luozzo G, Geisbüsch S, Lin HM, Bischoff MS, Schray D, Pawale A, Griepp RB. Open Repair of Descending and Thoracoabdominal Aortic Aneurysms and Dissections in Patients Aged Younger Than 60 Years: Superior to Endovascular Repair? The Annals Of Thoracic Surgery 2012, 95: 12-19. PMID: 22785215, DOI: 10.1016/j.athoracsur.2012.05.071.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAortic Aneurysm, ThoracicAortic DissectionBlood Vessel Prosthesis ImplantationCirculatory Arrest, Deep Hypothermia InducedFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedNew YorkRetrospective StudiesStentsSurvival RateTime FactorsTreatment OutcomeYoung AdultConceptsThoracoabdominal aortic aneurysmsEndovascular repairOpen repairStent graftingAortic aneurysmDeep hypothermic circulatory arrestPrevious aortic operationHypothermic circulatory arrestOpen surgical repairNeurologic complication rateCerebrospinal fluid drainageModality of choiceChronic dissectionAcute dissectionAortic complicationsAortic operationsDiversity of patientsYounger patientsCirculatory arrestCommon indicationComplication rateNeurologic monitoringSurgical repairEarly mortalityLinearized rateCerebral Protection for Aortic Arch Surgery: Deep Hypothermia
Di Luozzo G, Griepp RB. Cerebral Protection for Aortic Arch Surgery: Deep Hypothermia. Seminars In Thoracic And Cardiovascular Surgery 2012, 24: 127-130. PMID: 22920529, DOI: 10.1053/j.semtcvs.2011.12.006.Peer-Reviewed Original ResearchConceptsAortic arch surgeryArch surgeryDeep hypothermiaDeep hypothermic circulatory arrestBranched graft techniqueSelective cerebral perfusionTotal arch replacementHypothermic circulatory arrestAortic arch aneurysmArch replacementCerebral protectionArch aneurysmCerebral perfusionCirculatory arrestSurgical outcomesCardiac surgeonsGraft techniqueSurgeryHypothermiaAneurysmsPerfusionSurgeonsTechnical aspectsFrequency of Reoperations in Patients With Marfan Syndrome
Geisbuesch S, Schray D, Bischoff MS, Lin HM, Di Luozzo G, Griepp RB. Frequency of Reoperations in Patients With Marfan Syndrome. The Annals Of Thoracic Surgery 2012, 93: 1496-1501. PMID: 22443865, DOI: 10.1016/j.athoracsur.2011.12.068.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAneurysm, RupturedAortic Aneurysm, ThoracicAortic DissectionChildCohort StudiesElective Surgical ProceduresEmergency TreatmentFemaleFollow-Up StudiesHumansIncidenceKaplan-Meier EstimateMaleMarfan SyndromeMiddle AgedRadiographyReoperationRetrospective StudiesSex DistributionStatistics, NonparametricSurvival AnalysisTime FactorsTreatment OutcomeVascular Surgical ProceduresYoung AdultConceptsInitial emergency surgeryMarfan patientsGroup IAortic operationsEmergency surgeryInitial operationAortic segmentsElective root replacementInfrarenal aortic replacementThoracic aortic operationsGroup II patientsAortic root repairFrequency of reoperationArch operationsReoperative mortalityTotal reoperationsAcute dissectionAortic replacementOperative mortalityRoot replacementSurgical patientsThoracoabdominal aortaAortic ruptureII patientsRoot dilatationQuality of life and survival of septuagenarians and octogenarians after repair of descending and thoracoabdominal aortic aneurysms
Di Luozzo G, Shirali AS, Varghese R, Lin HM, Weiss AJ, Bischoff MS, Griepp RB. Quality of life and survival of septuagenarians and octogenarians after repair of descending and thoracoabdominal aortic aneurysms. Journal Of Thoracic And Cardiovascular Surgery 2012, 145: 378-384. PMID: 22365063, DOI: 10.1016/j.jtcvs.2012.01.068.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAortic Aneurysm, ThoracicFemaleHospital MortalityHumansKaplan-Meier EstimateLogistic ModelsMaleOdds RatioProportional Hazards ModelsQuality of LifeRespiratory Distress SyndromeRetrospective StudiesRisk AssessmentRisk FactorsSex FactorsSurveys and QuestionnairesTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsQuality of lifeBody mass indexGender-matched populationLong-term survivalHospital mortalityMass indexThoracoabdominal aortic aneurysm repairAcute respiratory distress syndromeHigher body mass indexComplex aortic operationsOne-year survivalThoracoabdominal aortic aneurysmsAortic aneurysm repairItem Health SurveyRespiratory distress syndromeLower vitality scoresTAAA repairAortic operationsElderly patientsAneurysm repairDistress syndromePostoperative qualityRetrospective reviewThoracic aneurysmLife scoresSelective cerebral perfusion for thoracic aortic surgery: Association with neurocognitive outcome
Uysal S, Lin HM, Fischer GW, Di Luozzo G, Reich DL. Selective cerebral perfusion for thoracic aortic surgery: Association with neurocognitive outcome. Journal Of Thoracic And Cardiovascular Surgery 2012, 143: 1205-1212. PMID: 22306226, DOI: 10.1016/j.jtcvs.2012.01.012.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAorta, ThoracicCardiopulmonary BypassCerebrovascular CirculationChi-Square DistributionCirculatory Arrest, Deep Hypothermia InducedCognitionCognition DisordersFemaleHumansLinear ModelsLogistic ModelsMaleMiddle AgedNeuropsychological TestsNew York CityPerfusionProspective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsSelective cerebral perfusionHypothermic circulatory arrestSelective cerebral perfusion timeCerebral perfusion timeCardiopulmonary bypass timeThoracic aortic surgeryCerebral perfusionCardiopulmonary bypassCirculatory arrestAortic surgeryBypass timeSurgical patientsNeurocognitive outcomesPerfusion timeHypothermic circulatory arrest timeAortic arch surgeryBrain protection strategiesGroup 3 patientsOptimal brain protectionPostoperative neurocognitive testingGroup 1 patientsGroup 2 patientsThoracic aortic repairCirculatory arrest timeNeurocognitive test scores
2011
Staged Approach Prevents Spinal Cord Injury in Hybrid Surgical-Endovascular Thoracoabdominal Aortic Aneurysm Repair: An Experimental Model
Bischoff MS, Scheumann J, Brenner RM, Ladage D, Bodian CA, Kleinman G, Ellozy SH, Di Luozzo G, Etz CD, Griepp RB. Staged Approach Prevents Spinal Cord Injury in Hybrid Surgical-Endovascular Thoracoabdominal Aortic Aneurysm Repair: An Experimental Model. The Annals Of Thoracic Surgery 2011, 92: 138-146. PMID: 21718839, DOI: 10.1016/j.athoracsur.2011.03.098.Peer-Reviewed Original ResearchMeSH KeywordsAngiographyAngioplastyAnimalsAortic Aneurysm, ThoracicCombined Modality TherapyDisease Models, AnimalFemaleFollow-Up StudiesIntraoperative ComplicationsMonitoring, IntraoperativeRandom AllocationRisk AssessmentSpinal CordSpinal Cord InjuriesStentsSurvival RateSwineTreatment OutcomeVascular Surgical ProceduresConceptsGroup 1Group 2Thoracoabdominal aortic aneurysm repairJuvenile Yorkshire pigsSevere ischemic damageHind limb functionAortic aneurysm repairStent graft occlusionLumbar spinal cordModified Tarlov scoreSpinal cord injuryEndovascular coverageTarlov scoreGraft occlusionAneurysm repairArtery ligationIntercostal arteriesIschemic damageCord injuryLimb functionSudden occlusionSpinal cordLower thoracicHistopathologic analysisPorcine modelSpinal Cord Preservation in Thoracoabdominal Aneurysm Repair
Bischoff MS, Di Luozzo G, Griepp EB, Griepp RB. Spinal Cord Preservation in Thoracoabdominal Aneurysm Repair. Perspectives In Vascular Surgery And Endovascular Therapy 2011, 23: 214-222. PMID: 21502113, DOI: 10.1177/1531003511400622.Peer-Reviewed Original ResearchConceptsSpinal cord injuryThoracoabdominal aneurysm repairAneurysm repairIncidence of paraplegiaSpinal cord preservationSpinal cord protectionEndovascular aortic repairOpen surgical repairSpinal cord vasculatureAortic repairEndovascular approachSurgical repairDreadful complicationCord injuryEndovascular proceduresCollateral networkInvasive natureRepairRecent technical advancementsParaparesisComplicationsParaplegiaInjuryIncidenceVasculature
2010
The Bentall procedure: Is it the gold standard? A series of 597 consecutive cases
Etz CD, Bischoff MS, Bodian C, Roder F, Brenner R, Griepp RB, Di Luozzo G. The Bentall procedure: Is it the gold standard? A series of 597 consecutive cases. Journal Of Thoracic And Cardiovascular Surgery 2010, 140: s64-s70. PMID: 21092800, DOI: 10.1016/j.jtcvs.2010.07.033.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAortic AneurysmAortic ValveBioprosthesisBlood Vessel Prosthesis ImplantationChi-Square DistributionFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHospital MortalityHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedNew York CityOdds RatioProsthesis DesignReoperationRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeYoung AdultConceptsAortic root reconstructionLong-term survivalBiological valvesMechanical valvesBentall procedureRoot reconstructionOverall hospital mortalityIndependent risk factorCoronary artery diseaseShort-term outcomesLong-term outcomesChoice of valveHospital mortalityPatients 50Artery diseaseDegenerative etiologyLinearized rateAortic valveConsecutive casesRisk factorsEmergency operationGold standardReoperationPatientsSurvivalNoninvasive cerebral oxygenation may predict outcome in patients undergoing aortic arch surgery
Fischer GW, Lin HM, Krol M, Galati MF, Di Luozzo G, Griepp RB, Reich DL. Noninvasive cerebral oxygenation may predict outcome in patients undergoing aortic arch surgery. Journal Of Thoracic And Cardiovascular Surgery 2010, 141: 815-821. PMID: 20579669, DOI: 10.1016/j.jtcvs.2010.05.017.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAorta, ThoracicBlood Vessel Prosthesis ImplantationCardiopulmonary BypassCirculatory Arrest, Deep Hypothermia InducedCritical CareFemaleFrontal LobeHeart Arrest, InducedHospital CostsHumansLength of StayLogistic ModelsMaleMiddle AgedMonitoring, IntraoperativeNew York CityOximetryOxygenPostoperative ComplicationsPredictive Value of TestsRespiration, ArtificialRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeConceptsRegional oxygen saturationAortic arch surgeryArch surgeryOxygen saturationOrgan dysfunctionIntensive care unit lengthRegional oxygen saturation valuesTotal aortic arch replacementPostoperative organ dysfunctionAortic arch replacementExtended hospital staySevere adverse outcomesCerebral oxygenation valuesOxygen saturation valuesArch replacementHemiarch replacementExtubation timeHospital lengthHospital stayPostoperative complicationsCerebral oximetryMinor complicationsConsiderable morbidityMajor complicationsSurgical repairLong-Term Survival After Open Repair of Chronic Distal Aortic Dissection
Zoli S, Etz CD, Roder F, Mueller CS, Brenner RM, Bodian CA, Di Luozzo G, Griepp RB. Long-Term Survival After Open Repair of Chronic Distal Aortic Dissection. The Annals Of Thoracic Surgery 2010, 89: 1458-1466. PMID: 20417761, DOI: 10.1016/j.athoracsur.2010.02.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAortic Aneurysm, AbdominalAortic Aneurysm, ThoracicAortic DissectionBlood Vessel Prosthesis ImplantationCause of DeathChronic DiseaseCohort StudiesDatabases, FactualDisease-Free SurvivalFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisPostoperative ComplicationsProbabilityRisk AssessmentSurvival AnalysisTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsChronic distal aortic dissectionDistal aortic dissectionAortic dissectionOpen repairAdverse outcomesAcute type ADistal aortic reoperationEndovascular stent-graft techniquesSegmental artery pairsStent-graft techniqueThrombosed false lumenCoronary artery diseaseLong-term survivalAortic reoperationChronic dissectionHospital mortalityB dissectionChronic dialysisAortic expansionVisceral arteriesArtery diseaseSurgical repairFalse lumenInitial diagnosisAortic diameter
2009
Aortic Arch Resection and Ligation of the Descending Thoracic Aorta to Manage a Ruptured Thoracoabdominal Aneurysm
Weiss A, Di Luozzo G, Etz CD, Griepp RB. Aortic Arch Resection and Ligation of the Descending Thoracic Aorta to Manage a Ruptured Thoracoabdominal Aneurysm. Vascular And Endovascular Surgery 2009, 43: 614-616. PMID: 19640920, DOI: 10.1177/1538574409335273.Peer-Reviewed Original ResearchConceptsThoracoabdominal aortic aneurysmsAcute type B aortic dissectionType B aortic dissectionAortic arch resectionRuptured thoracoabdominal aneurysmHigh-risk patientsOpen surgical interventionOpen surgical repairB aortic dissectionThoracoabdominal aneurysmsAortic dissectionAortic ruptureEndovascular approachSurgical repairArch resectionSurgical interventionAortic aneurysmThoracic aortaPrimary operationPatientsAneurysmsLess conventional approachesRuptureReoperationResection
2008
Reoperative aortic root and transverse arch procedures: A comparison with contemporaneous primary operations
Etz CD, Plestis KA, Homann TM, Bodian CA, Di Luozzo G, Spielvogel D, Griepp RB. Reoperative aortic root and transverse arch procedures: A comparison with contemporaneous primary operations. Journal Of Thoracic And Cardiovascular Surgery 2008, 136: 860-867.e3. PMID: 18954623, DOI: 10.1016/j.jtcvs.2007.11.071.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic Aneurysm, ThoracicAortic ValveBlood Vessel Prosthesis ImplantationCase-Control StudiesCause of DeathFollow-Up StudiesHeart Valve DiseasesHeart Valve Prosthesis ImplantationHospital MortalityHumansIntraoperative ComplicationsKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisPostoperative ComplicationsReoperationRetrospective StudiesTreatment OutcomeConceptsArch proceduresAorta proceduresArch operationsPrimary procedureOperative mortalityRisk factorsPoor long-term outlookSex-matched normal populationChronic obstructive pulmonary diseaseAortic arch operationsHigher hospital mortalityHigh operative mortalityProximal aortic surgeryLongevity of patientsObstructive pulmonary diseaseSeparate multivariable analysesLong-term outcomesSignificant risk factorsLong-term outlookLong-term survivalContemporaneous patientsAortic surgeryHospital mortalityEjection fractionMultivariable analysisChromium Infusion Reverses Extreme Insulin Resistance in a Cardiothoracic ICU Patient
Via M, Scurlock C, Raikhelkar J, Di Luozzo G, Mechanick JI. Chromium Infusion Reverses Extreme Insulin Resistance in a Cardiothoracic ICU Patient. Nutrition In Clinical Practice 2008, 23: 325-328. PMID: 18595867, DOI: 10.1177/0884533608318676.Peer-Reviewed Original ResearchConceptsInsulin resistanceExtreme insulin resistanceInsulin therapyGlycemic controlIll patientsAcute critical illnessIntensive insulin therapyProspective clinical trialsIntravenous insulin protocolThoracic aorta aneurysmSevere insulin resistanceUnits of insulinCritical illnessInsulin protocolICU patientsSurgical repairBlood sugarAorta aneurysmClinical trialsPatientsTherapyPressorAneurysmsGlucocorticoidsIllness
2007
Vascular Graft Replacement of the Ascending and Descending Aorta: Do Dacron Grafts Grow?
Etz CD, Homann T, Silovitz D, Bodian CA, Luehr M, Di Luozzo G, Plestis KA, Griepp RB. Vascular Graft Replacement of the Ascending and Descending Aorta: Do Dacron Grafts Grow? The Annals Of Thoracic Surgery 2007, 84: 1206-1213. PMID: 17888971, DOI: 10.1016/j.athoracsur.2007.05.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAortaAorta, ThoracicAortic DiseasesBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationChildCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPolyethylene TerephthalatesProbabilityProsthesis DesignProsthesis FailureReoperationRetrospective StudiesRisk AssessmentSurvival RateTreatment OutcomeConceptsDacron graftThoracic aortaGraft expansionPostoperative computed tomography scansAortic valve-sparing proceduresDevelopment of regurgitationDiseased aortic segmentMedian graft diameterRoutine postoperative surveillanceType III endoleakValve-sparing proceduresComputed tomography scanEntire thoracic aortaComputed tomography studyDacron vascular graftsVascular Dacron graftsVascular graft replacementAorta graftThoracoabdominal aneurysmsEndoluminal repairGraft replacementPostoperative surveillanceDescending AortaGraft diameterAortic segmentsAortic root reconstruction with a bioprosthetic valved conduit: A consecutive series of 275 procedures
Etz CD, Homann TM, Rane N, Bodian CA, Di Luozzo G, Plestis KA, Spielvogel D, Griepp RB. Aortic root reconstruction with a bioprosthetic valved conduit: A consecutive series of 275 procedures. Journal Of Thoracic And Cardiovascular Surgery 2007, 133: 1455-1463. PMID: 17532939, DOI: 10.1016/j.jtcvs.2007.01.058.Peer-Reviewed Original ResearchConceptsBioprosthetic valved conduitAortic root reconstructionValved conduitRoot reconstructionExtensive arch reconstructionOpen distal anastomosisPostoperative mortality rateAortic root replacementPatients 12 yearsRate of strokeHypothermic circulatory arrestLong-term outcomesLong-term survivalDegenerative aneurysmsHemiarch reconstructionHospital mortalityPermanent strokeAtherosclerotic aneurysmsRoot replacementArch reconstructionCirculatory arrestDistal anastomosisAdditional patientsDacron graftSignificant hemorrhage