2000
Research Units on Pediatric Psychopharmacology (Rupp) Autism Network Background and Rationale for an Initial Controlled Study of Risperidone
McDougle C, Scahill L, McCracken J, Aman M, Tierney E, Arnold L, Freeman B, Martin A, McGough J, Cronin P, Posey D, Riddle M, Ritz L, Swiezy N, Vitiello B, Volkmar F, Votolato N, Walson P. Research Units on Pediatric Psychopharmacology (Rupp) Autism Network Background and Rationale for an Initial Controlled Study of Risperidone. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 201-224. PMID: 10674197, DOI: 10.1016/s1056-4993(18)30142-1.Peer-Reviewed Original ResearchConceptsOpen-label trialDA neuronal systemsSafety of risperidoneStudy of RisperidonePlacebo-controlled studyUse of risperidoneExtrapyramidal side effectsTarget of pharmacotherapyTreatment of childrenImpaired social behaviorLong-term effectivenessPreclinical evidenceReceptor blockadeTypical antipsychoticsControlled StudyFirst drugPathophysiology of autismLower riskShort-term benefitsSide effectsRisperidonePotent effectsSymptoms of autismNeuronal systemsEnhanced efficacy
1999
Practice parameters for the assessment and treatment of children, adolescents, and adults with autism and other pervasive developmental disorders
Volkmar F, Cook E, Pomeroy J, Realmuto G, Tanguay P, Issues T. Practice parameters for the assessment and treatment of children, adolescents, and adults with autism and other pervasive developmental disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 32s-54s. PMID: 10624084, DOI: 10.1016/s0890-8567(99)80003-3.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderDevelopmental disordersRelated pervasive developmental disordersPatterns of delayCognitive skillsBehavioral problemsSyndrome expressionTreatment of childrenAutismCoordination of servicesPractice parametersTreatment modalitiesSustained interventionsMental retardationIndividualsDisordersClinical careAdolescentsDevianceSkillsFirst yearChildrenCareAdultsInterventionSummary of the Practice Parameters for the Assessment and Treatment of Children, Adolescents, and Adults With Autism and Other Pervasive Developmental Disorders
Volkmar F, Cook E, Pomeroy J, Realmuto G, Tanguay P. Summary of the Practice Parameters for the Assessment and Treatment of Children, Adolescents, and Adults With Autism and Other Pervasive Developmental Disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 1611-1615. PMID: 10596264, DOI: 10.1097/00004583-199912000-00028.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderDevelopmental disordersRelated pervasive developmental disordersTreatment of childrenPatterns of delayCognitive skillsBehavioral problemsSyndrome expressionAutismAdolescentsDisordersChildrenCoordination of servicesPractice parametersSustained interventionsTreatment modalitiesTreatment recommendationsMental retardationIndividualsClinical careDevianceSkillsFirst yearCliniciansTreatment
1997
Risperidone Treatment of Children and Adolescents With Pervasive Developmental Disorders: A Prospective, Open-Label Study
MCDOUGLE C, HOLMES J, BRONSON M, ANDERSON G, VOLKMAR F, PRICE L, COHEN D. Risperidone Treatment of Children and Adolescents With Pervasive Developmental Disorders: A Prospective, Open-Label Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 1997, 36: 685-693. PMID: 9136504, DOI: 10.1097/00004583-199705000-00020.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderDevelopmental disordersRisperidone treatmentClinical Global Impression ScaleOpen-label studyOpen-label trialPlacebo-controlled studyCommon side effectsEfficacy of risperidoneShort-term safetyGlobal Impression ScaleGlobal improvement itemBehavioral ratingsChildhood disintegrative disorderSocial relatednessTreatment of childrenAsperger's disorderRepetitive behaviorsAutistic disorderBehavioral symptomsBaseline visitMean ageImpression ScaleAdolescentsOptimal dose