Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders.
Zheng J, Zong X, Tang L, Guo H, Zhao P, Womer F, Zhang X, Tang Y, Wang F. Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders. Psychological Medicine 2024, 54: 2774-2784. PMID: 38804091, DOI: 10.1017/s0033291724000886.Peer-Reviewed Original ResearchGray matter volumeMood disordersGenetic vulnerabilityDepressive disorderHeterogeneity of mood disordersRegional gray matter volumeDrug-free patientsClinical behaviorIncreased genetic vulnerabilityGenetic riskSevere depressive symptomsClinical manifestationsBipolar disorderDrug-naiveFrontal cortexPolygenic risk scoresMatter volumeDepressive symptomsNeurocognitive assessmentCognitive impairmentPrimary motor cortexBehavioral termsDisordersHealthy controlsMotor cortexDysregulated cerebral blood flow, rather than gray matter Volume, exhibits stronger correlations with blood inflammatory and lipid markers in depression
Kang L, Wang W, Nie Z, Gong Q, Yao L, Xiang D, Zhang N, Tu N, Feng H, Zong X, Bai H, Wang G, Wang F, Bu L, Liu Z. Dysregulated cerebral blood flow, rather than gray matter Volume, exhibits stronger correlations with blood inflammatory and lipid markers in depression. NeuroImage Clinical 2024, 41: 103581. PMID: 38430800, PMCID: PMC10944186, DOI: 10.1016/j.nicl.2024.103581.Peer-Reviewed Original ResearchConceptsGray matter volumeCerebral blood flowMatter volumeArterial spin labelingRight middle temporal gyrusPredictors of MDDMiddle temporal gyrusImmune markersBrain functional changesProportion of MDDExploratory correlation analysisTumor necrosis factor-alphaBlood flowMDD patientsDepressive disorderAngular gyrusTemporal gyrusNecrosis factor-alphaMDDBrain regionsCerebral blood flow changesBlood lipid levelsInferior temporalCase-control comparisonCD4 countIntegrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder
Zheng J, Womer F, Tang L, Guo H, Zhang X, Tang Y, Wang F. Integrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder. Translational Psychiatry 2024, 14: 17. PMID: 38195555, PMCID: PMC10776753, DOI: 10.1038/s41398-023-02724-8.Peer-Reviewed Original ResearchConceptsGray matter volumeBrain structural deficitsFrontal cortexGMV changesStructural deficitsDecreased GMVGray matter volume abnormalitiesInferior frontal cortexAnterior cingulate cortexAllen Human Brain AtlasDifferentially methylated CpG positionsGray matter abnormalitiesHuman Brain AtlasRegionally specific correlationsDepressive disorderCingulate cortexMatter volumeMorphological deficitsMDDBetween-group differencesCortex regionsCortexSynaptic transmission processesDeficitsHealthy controls