2008
Postsynaptic Density-95 (PSD-95) and Calcineurin Control the Sensitivity of N-Methyl-d-aspartate Receptors to Calpain Cleavage in Cortical Neurons
Yuen EY, Ren Y, Yan Z. Postsynaptic Density-95 (PSD-95) and Calcineurin Control the Sensitivity of N-Methyl-d-aspartate Receptors to Calpain Cleavage in Cortical Neurons. Molecular Pharmacology 2008, 74: 360-370. PMID: 18445709, PMCID: PMC2858625, DOI: 10.1124/mol.108.046813.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptorsCortical neuronsNR2B subunitExtrasynaptic N-methyl-D-aspartate receptorsPermeable glutamate receptorsProtein postsynaptic densityTransient forebrain ischemiaCultured cortical neuronsDependent protease calpainSynaptic NMDAR responsesPostsynaptic density-95Calpain-dependent mannerWhole-cell currentsExcitotoxic conditionsForebrain ischemiaCortical slicesNMDA treatmentNMDAR currentsNMDAR responsesNMDAR functionSubstrates of calpainGlutamate receptorsNeuronal excitabilityCalpain cleavageDensity-95Modulation of Neuronal Excitability by Serotonin-NMDA Interactions in Prefrontal Cortex
Zhong P, Yuen E, Yan Z. Modulation of Neuronal Excitability by Serotonin-NMDA Interactions in Prefrontal Cortex. Molecular And Cellular Neuroscience 2008, 38: 290-299. PMID: 18455431, PMCID: PMC2477738, DOI: 10.1016/j.mcn.2008.03.003.Peer-Reviewed Original ResearchMeSH Keywords8-Hydroxy-2-(di-n-propylamino)tetralinAction PotentialsAnimalsExcitatory Amino Acid AgonistsExtracellular Signal-Regulated MAP KinasesMAP Kinase Signaling SystemN-MethylaspartateOrgan Culture TechniquesPrefrontal CortexPyramidal CellsRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AReceptors, N-Methyl-D-AspartateSerotoninSerotonin Receptor AgonistsStress, PhysiologicalSwimmingConceptsExtracellular signal-regulated kinaseProtein kinase AProtein kinase CActivation of ERKSignal-regulated kinaseNeuronal excitabilityKinase AMolecule downstreamERK activationPrefrontal cortexKinase CNMDA receptorsStressful conditionsMental disordersBiochemical evidencePFC neuronal firingPFC pyramidal neuronsPresence of NMDAAction potential firingNMDA-dependent mannerDPAT effectsAgonist alphaPyramidal neuronsReceptor subtypesActivation
2005
Regulation of N-Methyl-D-aspartate Receptors by Calpain in Cortical Neurons*
Wu HY, Yuen EY, Lu YF, Matsushita M, Matsui H, Yan Z, Tomizawa K. Regulation of N-Methyl-D-aspartate Receptors by Calpain in Cortical Neurons*. Journal Of Biological Chemistry 2005, 280: 21588-21593. PMID: 15790561, DOI: 10.1074/jbc.m501603200.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptorsNMDA receptorsNMDAR currentsCortical neuronsCalpain inhibitorsCultured cortical neuronsCortical pyramidal neuronsDynamin inhibitory peptideFunction of NMDARsInhibitory peptidesInvolvement of calpainNMDAR-mediated currentsNMDAR channel functionSelective calpain inhibitorsNMDAR internalizationNMDAR overstimulationNeuroprotective mechanismsPyramidal neuronsNMDA treatmentBath applicationIntracellular injectionNR2B subunitCalcium entryPathologic functionsProlonged treatment