2012
Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
Jiang H, Ren Y, Yuen E, Zhong P, Ghaedi M, Hu Z, Azabdaftari G, Nakaso K, Yan Z, Feng J. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nature Communications 2012, 3: 668. PMID: 22314364, PMCID: PMC3498452, DOI: 10.1038/ncomms1669.Peer-Reviewed Original ResearchConceptsMidbrain DA neuronsDA neuronsParkinson's diseaseDopamine utilizationDopaminergic neuronsHuman midbrain dopaminergic neuronsSpontaneous DA releaseNigral DA neuronsNigral dopaminergic neuronsDisease-modifying therapiesMidbrain dopaminergic neuronsParkin knockout miceStem cellsPluripotent stem cellsPD patientsDA releaseDA neurotransmissionDA uptakeNormal subjectsKnockout miceParkin mutationsNovel targetNeuronsOxidative stressMonoamine oxidase
2010
Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory
Yuen EY, Liu W, Karatsoreos IN, Ren Y, Feng J, McEwen BS, Yan Z. Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Molecular Psychiatry 2010, 16: 156-170. PMID: 20458323, PMCID: PMC3108461, DOI: 10.1038/mp.2010.50.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBiophysicsCells, CulturedCorticosteroneDose-Response Relationship, DrugDrug InteractionsElectric StimulationExcitatory Amino Acid AgentsExcitatory Postsynaptic PotentialsGene Expression RegulationGlutamic AcidGreen Fluorescent ProteinsHormone AntagonistsImmediate-Early ProteinsIn Vitro TechniquesLong-Term PotentiationMaleMaze LearningMemory, Short-TermMifepristonePatch-Clamp TechniquesPeptidesPrefrontal CortexProtein Serine-Threonine KinasesPyramidal CellsRab GTP-Binding ProteinsRatsRats, Sprague-DawleyReceptors, GlutamateRNA, Small InterferingStress, PsychologicalSynaptic TransmissionTime FactorsTransfectionConceptsPrefrontal cortexGlutamatergic transmissionAcid receptorsPFC pyramidal neuronsAspartic acid (NMDA) receptorsIsoxazolepropionic acid (AMPA) receptorsInduction of serumCorticosteroid stress hormonesFunction of NMDARsStress-induced enhancementSustained potentiationPyramidal neuronsCorticosterone treatmentSynaptic responsesSynaptic transmissionBehavioral stressorsGlucocorticoid-inducible kinaseGlucocorticoid receptorAcute stressStress hormonesΑ-aminoSurface expressionReceptorsUnderlying mechanismReceptor recycling
2007
The Phosphorylation State of GluR1 Subunits Determines the Susceptibility of AMPA Receptors to Calpain Cleavage*
Yuen EY, Liu W, Yan Z. The Phosphorylation State of GluR1 Subunits Determines the Susceptibility of AMPA Receptors to Calpain Cleavage*. Journal Of Biological Chemistry 2007, 282: 16434-16440. PMID: 17428797, DOI: 10.1074/jbc.m701283200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesCalpainCells, CulturedCerebral CortexEnzyme ActivationNeuronsPhosphoprotein PhosphatasesPhosphorylationProtein Phosphatase 1Protein Processing, Post-TranslationalProtein SubunitsRatsRats, Sprague-DawleyReceptors, AMPATime FactorsConceptsCalpain cleavagePhosphorylation stateProteolytic cleavageDependent protein kinase IITerminal fusion proteinEffect of phosphorylationProtein phosphatase 1/2AProtein kinase IIPhosphorylation sitesProtein kinaseCalpain cleavage sitesGluR1 subunitKinase IIFusion proteinActive CaMKIIAMPAR currentsCalpain regulationCleavage siteIsoxazoleproprionic acid (AMPA) receptorSubunitsIonotropic glutamate receptorsN-methyl-D-aspartate receptorsPhysiological studiesExcitatory synaptic transmissionAMPA receptor currents
2005
Regulation of N-Methyl-D-aspartate Receptors by Calpain in Cortical Neurons*
Wu HY, Yuen EY, Lu YF, Matsushita M, Matsui H, Yan Z, Tomizawa K. Regulation of N-Methyl-D-aspartate Receptors by Calpain in Cortical Neurons*. Journal Of Biological Chemistry 2005, 280: 21588-21593. PMID: 15790561, DOI: 10.1074/jbc.m501603200.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptorsNMDA receptorsNMDAR currentsCortical neuronsCalpain inhibitorsCultured cortical neuronsCortical pyramidal neuronsDynamin inhibitory peptideFunction of NMDARsInhibitory peptidesInvolvement of calpainNMDAR-mediated currentsNMDAR channel functionSelective calpain inhibitorsNMDAR internalizationNMDAR overstimulationNeuroprotective mechanismsPyramidal neuronsNMDA treatmentBath applicationIntracellular injectionNR2B subunitCalcium entryPathologic functionsProlonged treatment