2017
Molecular and Epigenetic Mechanisms for the Complex Effects of Stress on Synaptic Physiology and Cognitive Functions
Yuen EY, Wei J, Yan Z. Molecular and Epigenetic Mechanisms for the Complex Effects of Stress on Synaptic Physiology and Cognitive Functions. The International Journal Of Neuropsychopharmacology 2017, 20: 948-955. PMID: 29016816, PMCID: PMC5737802, DOI: 10.1093/ijnp/pyx052.Peer-Reviewed Original ResearchConceptsEpigenetic mechanismsReceptor membrane traffickingStress-induced regulationSynaptic physiologyMembrane traffickingEpigenetic controlCytoskeleton networkGene expressionKey moleculesComplex effectsStress-related mental disordersPresynaptic glutamate releaseExcitatory synaptic transmissionStress-induced modulationPhysiologyGlutamatergic transmissionGlutamate releaseSynaptic transmissionBiphasic effectAnimal studiesComplex changesMental disordersBrain regionsChronic stressStress hormones
2015
Estrogen in prefrontal cortex blocks stress-induced cognitive impairments in female rats
Yuen EY, Wei J, Yan Z. Estrogen in prefrontal cortex blocks stress-induced cognitive impairments in female rats. The Journal Of Steroid Biochemistry And Molecular Biology 2015, 160: 221-226. PMID: 26321384, PMCID: PMC4769981, DOI: 10.1016/j.jsbmb.2015.08.028.Peer-Reviewed Original ResearchConceptsPrefrontal cortexPFC of femalesStress-induced cognitive impairmentGlutamate receptor surface expressionSame stress paradigmCognitive behaviorMemory impairmentCognitive impairmentGlutamatergic deficitsStress paradigmFemale ratsLevels of aromataseContribution of estrogenNormal synaptic functionImpairmentReceptor surface expressionBiosynthesis of estrogensGlutamatergic transmissionPyramidal neuronsMale ratsEstrogen receptorCognitionHuman studiesProtective roleSynaptic function
2010
Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors
Yuen EY, Zhong P, Yan Z. Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 22308-22313. PMID: 21135234, PMCID: PMC3009820, DOI: 10.1073/pnas.1010025108.Peer-Reviewed Original ResearchConceptsSynaptic transmissionPrefrontal cortex pyramidal neuronsCortex pyramidal neuronsExcitatory synaptic transmissionAttention deficit hyperactivity disorderRole of dopamineDopamine D4 receptorGlutamatergic transmissionPyramidal neuronsCortical excitabilityProfound depressionMental disordersSynaptic functionBrain regionsD4 receptorsSynaptic factorsAMPAR traffickingPrefrontal cortexDistinct signaling pathwaysHyperactivity disorderCaMKII activityBidirectional regulationHomeostatic regulationReceptorsSignaling pathwaysRegulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons
Yuen EY, Liu W, Kafri T, Van Praag H, Yan Z. Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons. The Journal Of Physiology 2010, 588: 2361-2371. PMID: 20442266, PMCID: PMC2915513, DOI: 10.1113/jphysiol.2009.186353.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCells, CulturedCerebral CortexCofilin 1ElectrophysiologyExcitatory Postsynaptic PotentialsImmunohistochemistryLentivirusMicrofilament ProteinsNeuronal PlasticityNeuronsPhosphoric Monoester HydrolasesRatsReceptors, AMPARNA, Small InterferingRNA, ViralSynapsesSynaptic TransmissionConceptsExcitatory postsynaptic currentsCortical neuronsSynaptic transmissionSynaptic plasticityReceptor-mediated excitatory postsynaptic currentsAMPA receptor-mediated excitatory postsynaptic currentsPhosphatase SlingshotActin dynamicsAMPA receptor channelsFunction-blocking antibodiesSmall RNA interferenceAMPAR EPSCsMajor actin depolymerizing factorPostsynaptic currentsCofilin phosphatase SlingshotGluR-1Synaptic functionActin depolymerizing factorSpine morphologyAMPAR traffickingReceptor channelsActin cytoskeletonRNA interferenceNeuronsCofilin activationThe Stress Hormone Corticosterone Increases Synaptic α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors via Serum- and Glucocorticoid-inducible Kinase (SGK) Regulation of the GDI-Rab4 Complex*
Liu W, Yuen EY, Yan Z. The Stress Hormone Corticosterone Increases Synaptic α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors via Serum- and Glucocorticoid-inducible Kinase (SGK) Regulation of the GDI-Rab4 Complex*. Journal Of Biological Chemistry 2010, 285: 6101-6108. PMID: 20051515, PMCID: PMC2825404, DOI: 10.1074/jbc.m109.050229.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsCell LineCerebral CortexCorticosteroneGuanine Nucleotide Dissociation InhibitorsImmediate-Early ProteinsMiceNeuronsProtein Serine-Threonine KinasesProtein TransportRab4 GTP-Binding ProteinsRatsReceptors, AMPAReceptors, NeurotransmitterSynapsesUp-RegulationConceptsNucleotide Dissociation InhibitorSer-213Glucocorticoid-inducible kinaseRab proteinsKinase regulationDissociation inhibitorIsoxazolepropionic acid (AMPA) receptorsSmall GTPaseEarly endosomesAcid receptorsFunctional cycleCorticosteroid signalingSGK phosphorylationPlasma membraneRab4Receptor recyclingMolecular mechanismsCellular targetsCorticosteroid stress hormonesNeuronal functionPhosphorylationSurface expressionStress hormonesMembraneRegulationDelivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin
Twelvetrees A, Yuen E, Arancibia-Carcamo I, MacAskill A, Rostaing P, Lumb M, Humbert S, Triller A, Saudou F, Yan Z, Kittler J. Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin. Neuron 2010, 65: 53-65. PMID: 20152113, PMCID: PMC2841506, DOI: 10.1016/j.neuron.2009.12.007.Peer-Reviewed Original ResearchConceptsHuntingtin-associated protein 1Huntington's diseaseInhibitory postsynaptic currentsMutant huntingtinInhibitory synaptic currentsBrain excitabilityPostsynaptic currentsSynaptic inhibitionTherapeutic approachesSynaptic currentsDiseaseBrain information processingMolecular targetsSynapsesProtein 1Protein 5Protein huntingtinHuntingtinReceptorsPolyglutamine repeatsInhibitionGABAARsExcitability
2009
Ubiquitin-dependent lysosomal targeting of GABAA receptors regulates neuronal inhibition
Arancibia-Cárcamo I, Yuen E, Muir J, Lumb M, Michels G, Saliba R, Smart T, Yan Z, Kittler J, Moss S. Ubiquitin-dependent lysosomal targeting of GABAA receptors regulates neuronal inhibition. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 17552-17557. PMID: 19815531, PMCID: PMC2762659, DOI: 10.1073/pnas.0905502106.Peer-Reviewed Original ResearchConceptsSynaptic inhibitionGamma2 subunitInhibitory transmissionCerebral ischemiaAnoxic insultNeuronal inhibitionGABAA receptorsExcitatory currentsSynaptic sitesLysosomal targetingPathological conditionsLysosomal activityUnknown mechanismInhibitionReceptorsMolecular mechanismsIntracellular domainTargetingPathwayIschemiaNeuropathologyEndocytic pathwayInsult
2007
Calpain regulation of AMPA receptor channels in cortical pyramidal neurons
Yuen EY, Gu Z, Yan Z. Calpain regulation of AMPA receptor channels in cortical pyramidal neurons. The Journal Of Physiology 2007, 580: 241-254. PMID: 17234699, PMCID: PMC2075435, DOI: 10.1113/jphysiol.2006.122754.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCalpainCells, CulturedCerebral CortexElectrophysiologyEndocytosisGerbillinaeImmunohistochemistryMaleMAP Kinase Kinase 2NeuronsNeuroprotective AgentsPatch-Clamp TechniquesPyramidal CellsRatsRats, Sprague-DawleyReceptors, AMPAReceptors, Cell SurfaceReceptors, N-Methyl-D-AspartateStimulation, ChemicalSynapsesSynaptic TransmissionConceptsCortical pyramidal neuronsNMDA receptorsPyramidal neuronsAMPA receptorsNMDA treatmentCalpain inhibitorsIschaemia-induced depressionFast excitatory synaptic transmissionTransient ischemic insultAMPAR-mediated currentsExcitatory synaptic transmissionCalpain-dependent mannerAMPA receptor channelsSelective calpain inhibitorsExcitotoxic conditionsIschemic animalsIschemic insultNeuronal excitotoxicityAMPAR currentsAMPA responsesCortical culturesExtracellular glutamateGlutamate receptorsGlutamate triggersNeuronal excitability
2005
Activation of Dopamine D4 Receptors Induces Synaptic Translocation of Ca2+/Calmodulin-Dependent Protein Kinase II in Cultured Prefrontal Cortical Neurons
Gu Z, Jiang Q, Yuen E, Yan Z. Activation of Dopamine D4 Receptors Induces Synaptic Translocation of Ca2+/Calmodulin-Dependent Protein Kinase II in Cultured Prefrontal Cortical Neurons. Molecular Pharmacology 2005, 69: 813-822. PMID: 16365279, DOI: 10.1124/mol.105.018853.Peer-Reviewed Original ResearchConceptsD4 receptor activationDependent protein kinase IIProtein kinase IIAlpha-CaMKIID4 receptorsDopamine D4 receptorCaMKII translocationKinase IIReceptor activationF-actinSynaptic translocationPostsynaptic sitesBinding of CaMKIITrisphosphate receptor/Ca2Receptor-mediated excitatory postsynaptic currentsAMPA receptor-mediated excitatory postsynaptic currentsPhospholipase C/inositolPrefrontal cortexCalmodulin binding siteExcitatory postsynaptic currentsGlutamate receptor 1 (GluR1) subunitPrefrontal cortical neuronsD4 receptor stimulationAutophosphorylation sitesSubcellular localizationSerotonin 5-HT1A Receptors Regulate NMDA Receptor Channels through a Microtubule-Dependent Mechanism
Yuen EY, Jiang Q, Chen P, Gu Z, Feng J, Yan Z. Serotonin 5-HT1A Receptors Regulate NMDA Receptor Channels through a Microtubule-Dependent Mechanism. Journal Of Neuroscience 2005, 25: 5488-5501. PMID: 15944377, PMCID: PMC6724987, DOI: 10.1523/jneurosci.1187-05.2005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesDendritesExtracellular Signal-Regulated MAP KinasesIn Vitro TechniquesKinesinsMembrane PotentialsMicrotubulesMolecular Motor ProteinsNeuronsPatch-Clamp TechniquesPrefrontal CortexProtein SubunitsProtein TransportRatsReceptor, Serotonin, 5-HT1AReceptors, N-Methyl-D-AspartateSerotoninSerotonin 5-HT1 Receptor AgonistsSynapsesConceptsMicrotubule-dependent mechanismMEK/ERKNMDA receptorsPrefrontal cortexMicrotubule stabilityDendritic transportNMDAR interactionMicrotubule assemblyBiochemical evidenceMEK inhibitorsPFC pyramidal neuronsNMDA receptor channelsRole of serotoninCaMKIIERKNeuronal dendritesNMDAR functionMicrotubule stabilizerPathological conditionsPrimary targetReceptor channelsPyramidal neuronsNMDAR currentsSerotonin systemReceptors