2012
Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease
Yuen EY, Wei J, Zhong P, Yan Z. Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease. Neurobiology Of Disease 2012, 46: 497-502. PMID: 22402331, PMCID: PMC3323696, DOI: 10.1016/j.nbd.2012.02.015.Peer-Reviewed Original ResearchConceptsHuntingtin associated protein 1Mouse modelHuntington's diseaseSynaptic inhibitionExcitatory/inhibitory balanceInhibitory synaptic efficacyDiminished surface expressionNeurodegenerative movement disorderTransgenic mouse modelHD mouse modelsNeuronal excitotoxicityInhibitory balanceMovement disordersAssociated protein 1Synaptic transmissionGABAAR traffickingSynaptic efficacySynaptic functionDiseaseReceptorsMutant huntingtinProtein 1Protein 5Surface expressionPolyglutamine repeats
2010
Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin
Twelvetrees A, Yuen E, Arancibia-Carcamo I, MacAskill A, Rostaing P, Lumb M, Humbert S, Triller A, Saudou F, Yan Z, Kittler J. Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin. Neuron 2010, 65: 53-65. PMID: 20152113, PMCID: PMC2841506, DOI: 10.1016/j.neuron.2009.12.007.Peer-Reviewed Original ResearchConceptsHuntingtin-associated protein 1Huntington's diseaseInhibitory postsynaptic currentsMutant huntingtinInhibitory synaptic currentsBrain excitabilityPostsynaptic currentsSynaptic inhibitionTherapeutic approachesSynaptic currentsDiseaseBrain information processingMolecular targetsSynapsesProtein 1Protein 5Protein huntingtinHuntingtinReceptorsPolyglutamine repeatsInhibitionGABAARsExcitability
2009
Ubiquitin-dependent lysosomal targeting of GABAA receptors regulates neuronal inhibition
Arancibia-Cárcamo I, Yuen E, Muir J, Lumb M, Michels G, Saliba R, Smart T, Yan Z, Kittler J, Moss S. Ubiquitin-dependent lysosomal targeting of GABAA receptors regulates neuronal inhibition. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 17552-17557. PMID: 19815531, PMCID: PMC2762659, DOI: 10.1073/pnas.0905502106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexLeupeptinsLysosomesMicroscopy, ConfocalNeuronsProtein SubunitsRatsReceptors, GABA-ASynapsesUbiquitinConceptsSynaptic inhibitionGamma2 subunitInhibitory transmissionCerebral ischemiaAnoxic insultNeuronal inhibitionGABAA receptorsExcitatory currentsSynaptic sitesLysosomal targetingPathological conditionsLysosomal activityUnknown mechanismInhibitionReceptorsMolecular mechanismsIntracellular domainTargetingPathwayIschemiaNeuropathologyEndocytic pathwayInsultDopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism*
Graziane N, Yuen E, Yan Z. Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism*. Journal Of Biological Chemistry 2009, 284: 8329-8336. PMID: 19179335, PMCID: PMC2659191, DOI: 10.1074/jbc.m807387200.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCell MembraneCofilin 1Protein TransportRatsReceptors, Dopamine D4Receptors, GABA-ASignal TransductionConceptsTransport of vesiclesActin depolymerizing factorMyosin motor proteinsActin-dependent mechanismActin-binding siteMajor actin depolymerizing factorActin dynamicsPlasma membraneMotor proteinsActin depolymerizationActin filamentsMyosin proteinCellular mechanismsDephosphorylationPotential involvementProteinReceptor activationRegulationRegulation of dopamineReceptorsActin stabilizer phalloidinCofilinTraffickingDopamine D4 receptorLatrunculin