2009
Dopamine D4 Receptors Regulate AMPA Receptor Trafficking and Glutamatergic Transmission in GABAergic Interneurons of Prefrontal Cortex
Yuen EY, Yan Z. Dopamine D4 Receptors Regulate AMPA Receptor Trafficking and Glutamatergic Transmission in GABAergic Interneurons of Prefrontal Cortex. Journal Of Neuroscience 2009, 29: 550-562. PMID: 19144855, PMCID: PMC2768380, DOI: 10.1523/jneurosci.5050-08.2009.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsCalcineurinColchicineDopamine AgentsEnzyme InhibitorsGamma-Aminobutyric AcidGlutamate DecarboxylaseGlutamic AcidGreen Fluorescent ProteinsIn Vitro TechniquesInterneuronsMiceMice, TransgenicMicrofilament ProteinsPatch-Clamp TechniquesPhalloidinePhosphoric Monoester HydrolasesPrefrontal CortexProtein TransportRatsReceptors, AMPAReceptors, Dopamine D4RNA, Small InterferingSynaptic TransmissionTransfectionTubulin ModulatorsConceptsGABAergic interneuronsAttention deficit hyperactivity disorderGABAergic inhibitionGlutamatergic transmissionPrefrontal cortexAMPAR-mediated synaptic transmissionLocal circuit neuronsPFC pyramidal neuronsExcitatory synaptic strengthAbnormal neural synchronyAMPA receptor traffickingDopamine D4 receptorAMPAR EPSCsDeficit hyperactivity disorderPFC interneuronsPyramidal neuronsMajor actin depolymerizing factorMemory disturbanceSynaptic transmissionAMPA receptorsCortical circuitsNeuronal activityPersistent suppressionInterneuronsMental disorders
2007
Serotonergic Regulation of NMDA Receptor Trafficking and Function in Prefrontal Cortex
Yuen E, Yan Z. Serotonergic Regulation of NMDA Receptor Trafficking and Function in Prefrontal Cortex. 2007, 91-101. DOI: 10.1007/978-0-387-72256-6_5.Peer-Reviewed Original ResearchPrefrontal cortexPFC neuronsBrain stem raphe nucleiPrimary neuronal populationsPyramidal projection neuronsNMDA receptor traffickingMultiple brain regionsProjection neuronsRaphe nucleusBasal gangliaBrain stemGABAergic interneuronsLimbic areasSerotonergic regulationWidespread projectionsNeuronal populationsFrontal lobeBehavioral testsBrain regionsDelayed-response taskCortexNeuronsMajor targetReceptor traffickingSerotonin