2011
Amyloid β Peptide-(1–42) Induces Internalization and Degradation of β2 Adrenergic Receptors in Prefrontal Cortical Neurons*
Wang D, Yuen E, Zhou Y, Yan Z, Xiang Y. Amyloid β Peptide-(1–42) Induces Internalization and Degradation of β2 Adrenergic Receptors in Prefrontal Cortical Neurons*. Journal Of Biological Chemistry 2011, 286: 31852-31863. PMID: 21757762, PMCID: PMC3173113, DOI: 10.1074/jbc.m111.244335.Peer-Reviewed Original ResearchConceptsPrefrontal cortical neuronsCortical neuronsAdrenergic receptorsAMPA receptor-mediated miniature excitatory postsynaptic currentsG protein-coupled receptor kinase phosphorylationMiniature excitatory postsynaptic currentsCerebrum of miceΒAR agonist isoproterenolAmyloid precursor protein geneExcitatory postsynaptic currentsG protein-coupled receptor kinasesPrecursor protein geneProtein-coupled receptor kinasesReceptor subunit 1Mutant presenilin 1Receptor kinase phosphorylationGlutamatergic activityGlutamatergic regulationAβ bindsInduces desensitizationAβ treatmentPostsynaptic currentsΒ2-adrenergic receptorSynaptic activityAgonist isoproterenol
2009
Assembly of a β2‐adrenergic receptor—GluR1 signalling complex for localized cAMP signalling
Joiner M, Lisé M, Yuen E, Kam A, Zhang M, Hall D, Malik Z, Qian H, Chen Y, Ulrich J, Burette A, Weinberg R, Law P, El‐Husseini A, Yan Z, Hell J. Assembly of a β2‐adrenergic receptor—GluR1 signalling complex for localized cAMP signalling. The EMBO Journal 2009, 29: 482-495. PMID: 19942860, PMCID: PMC2824466, DOI: 10.1038/emboj.2009.344.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesAnimalsCalcium ChannelsCells, CulturedCerebral CortexCyclic AMP-Dependent Protein KinasesDisks Large Homolog 4 ProteinElectrophysiologyGene Expression RegulationGTP-Binding Protein alpha Subunits, GsHippocampusIntracellular Signaling Peptides and ProteinsMembrane ProteinsNeuronsRatsRats, Sprague-DawleyReceptors, Adrenergic, beta-2Receptors, AMPAConceptsUnknown molecular mechanismsMajor target proteinGluR1 surface expressionLocalized cAMPTarget proteinsMolecular mechanismsPhosphorylation of GluR1Selective regulationAdenylyl cyclaseProteinPSD-95PhosphorylationSurface expressionGlutamate receptor subunits GluR1PKAAssemblyPostsynaptic sitesCentral noradrenergic signalingHomologuesSubunit GluR1ComplexesCAMPSignalingAdrenergic receptorsStargazin