2018
Prognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors
Strosberg D, Schneider EB, Onesti J, Saunders N, Konda B, Shah M, Dillhoff M, Schmidt CR, Shirley LA. Prognostic Impact of Serum Pancreastatin Following Chemoembolization for Neuroendocrine Tumors. Annals Of Surgical Oncology 2018, 25: 3613-3620. PMID: 30182331, DOI: 10.1245/s10434-018-6741-x.Peer-Reviewed Original ResearchConceptsRepeat transarterial chemoembolizationMetastatic neuroendocrine tumorsTransarterial chemoembolizationPancreastatin levelsNeuroendocrine tumorsOverall survivalPrognostic impactImproved overall survivalProgressive liver diseaseFirst transarterial chemoembolizationWorse overall survivalUseful prognostic indicatorLong-term survivalPg/mLConclusionsFor patientsPost TACECarcinoid syndromeTACE treatmentLiver metastasesPatient demographicsImproved survivalLiver diseasePoor outcomePrognostic indicatorResultsA totalNeutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases
McDermott SM, Saunders ND, Schneider EB, Strosberg D, Onesti J, Dillhoff M, Schmidt CR, Shirley LA. Neutrophil lymphocyte ratio and transarterial chemoembolization in neuroendocrine tumor metastases. Journal Of Surgical Research 2018, 232: 369-375. PMID: 30463743, DOI: 10.1016/j.jss.2018.06.058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChemoembolization, TherapeuticFemaleFollow-Up StudiesHumansKaplan-Meier EstimateLeukocyte CountLiver NeoplasmsLymphocytesMaleMiddle AgedNeuroendocrine TumorsNeutrophilsPreoperative PeriodPrognosisResponse Evaluation Criteria in Solid TumorsRetrospective StudiesYoung AdultConceptsMedian overall survivalMetastatic neuroendocrine tumorsTransarterial chemoembolizationOverall survivalNeuroendocrine tumorsSingle tertiary medical centerCancer-related treatmentTertiary medical centerNeuroendocrine tumor metastasesPotential treatment strategyElevated NLRLiver metastasesNLR valuesIndependent predictorsBlood workLymphocyte ratioEntire cohortTreatment strategiesPostprocedural careMedical CenterPatientsMultivariate analysisNLRTumor metastasisChemoembolization
2016
Epidemiologic Trends of Chemical Ocular Burns in the United States
Haring R, Sheffield I, Channa R, Canner J, Schneider E. Epidemiologic Trends of Chemical Ocular Burns in the United States. JAMA Ophthalmology 2016, 134: 1119-1124. PMID: 27490908, DOI: 10.1001/jamaophthalmol.2016.2645.Peer-Reviewed Original ResearchConceptsChemical ocular burnsEmergency departmentOcular burnsEpidemiologic trendsAcid injuryHealth care insuranceChemical burnsNationwide Emergency Department SampleChemical eye injuriesEmergency department chargesTotal emergency departmentOcular chemical burnsOcular chemical injuryEmergency Department SampleHigh-risk groupSingle high-risk groupAge-specific ratesPrivate health care insuranceCare insuranceAlkali injuryED presentationsEye injuriesMedian agePatient ageFemale patientsImplementation of a Comprehensive Post-Discharge Venous Thromboembolism Prophylaxis Program for Abdominal and Pelvic Surgery Patients
Najjar PA, Madenci AL, Zogg CK, Schneider EB, Dankers CA, Pimentel MT, Chabria AS, Goldberg JE, Sharma G, Piazza G, Bleday R, Orgill DP, Kachalia A. Implementation of a Comprehensive Post-Discharge Venous Thromboembolism Prophylaxis Program for Abdominal and Pelvic Surgery Patients. Journal Of The American College Of Surgeons 2016, 223: 804-813. PMID: 27693288, PMCID: PMC6309555, DOI: 10.1016/j.jamcollsurg.2016.09.010.Peer-Reviewed Original ResearchConceptsPost-intervention cohortPre-intervention cohortInflammatory bowel diseaseVenous thromboembolismProphylaxis programAbdominal surgeryBowel diseasePost-discharge VTE ratesVenous thromboembolism prophylaxis programBedside medication deliveryInpatient venous thromboembolismInstitutional American CollegeSymptomatic venous thromboembolismPrimary end pointMajor abdominal surgeryVTE prevention programSingle-institution retrospectiveSurgeons NSQIP datasetPost-intervention analysisProphylactic anticoagulationVTE prophylaxisVTE ratesVTE eventsNSQIP datasetRisk patientsPredictors of emergency ventral hernia repair: Targets to improve patient access and guide patient selection for elective repair
Wolf LL, Scott JW, Zogg CK, Havens JM, Schneider EB, Smink DS, Salim A, Haider AH. Predictors of emergency ventral hernia repair: Targets to improve patient access and guide patient selection for elective repair. Surgery 2016, 160: 1379-1391. PMID: 27542434, DOI: 10.1016/j.surg.2016.06.027.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overConfidence IntervalsDatabases, FactualElective Surgical ProceduresEmergenciesFemaleFollow-Up StudiesHealth Services AccessibilityHernia, VentralHerniorrhaphyHospital MortalityHumansInsurance CoverageLogistic ModelsMaleMiddle AgedOdds RatioPatient SelectionPredictive Value of TestsQuality ImprovementRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeConceptsVentral hernia repairEmergency ventral hernia repairHospital-level factorsHernia repairIndependent predictorsPatient selectionElective operationsWorse outcomesEmergency repairLonger hospital stayNationwide Inpatient SampleMultivariable logistic regressionUnited States populationRace/ethnicityHospital deathHospital staySecondary outcomesElective repairPrimary outcomePayer statusInpatient SamplePatient outcomesVentral herniasElective careGreater oddsOutcomes of abdominoperineal resection for management of anal cancer in HIV-positive patients: a national case review
Leeds IL, Alturki H, Canner JK, Schneider EB, Efron JE, Wick EC, Gearhart SL, Safar B, Fang SH. Outcomes of abdominoperineal resection for management of anal cancer in HIV-positive patients: a national case review. World Journal Of Surgical Oncology 2016, 14: 208. PMID: 27495294, PMCID: PMC4974747, DOI: 10.1186/s12957-016-0970-x.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAdultAge FactorsAgedAnus NeoplasmsCarcinoma, Squamous CellComorbidityFemaleFollow-Up StudiesHealth Status DisparitiesHIV InfectionsHospital MortalityHumansIncidenceLength of StayMaleMiddle AgedNeoplasm Recurrence, LocalPerineumPostoperative ComplicationsRetrospective StudiesRisk FactorsSalvage TherapyTreatment OutcomeConceptsHIV-positive patientsLength of stayHIV-negative patientsAnal cancerNational Inpatient SampleAbdominoperineal resectionHospitalization costsHIV infectionAnal squamous cell cancerAnal squamous cell carcinomaUtilization Project National Inpatient SampleGreater hospitalization costsWorse postoperative recoveryHIV-positive groupMethodsA retrospective reviewAnal cancer patientsSquamous cell cancerHuman immunodeficiency virusMultivariable logistic regressionSquamous cell carcinomaHospital mortalityHospital stayPerioperative complicationsPostoperative hemorrhagePostoperative outcomes
2015
Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Study
Zysk AM, Chen K, Gabrielson E, Tafra L, May Gonzalez EA, Canner JK, Schneider EB, Cittadine AJ, Scott Carney P, Boppart SA, Tsuchiya K, Sawyer K, Jacobs LK. Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Study. Annals Of Surgical Oncology 2015, 22: 3356-3362. PMID: 26202553, PMCID: PMC4839389, DOI: 10.1245/s10434-015-4665-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularFeasibility StudiesFemaleFollow-Up StudiesHumansIntraoperative PeriodMastectomy, SegmentalMicrosurgeryMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisProspective StudiesReoperationTomography, Optical CoherenceConceptsBreast-conserving surgeryPositive marginsFinal marginsIntraoperative assessmentEarly-stage breast cancerMajority of reoperationsBreast conserving surgeryFinal surgical marginsMethodsForty-six patientsCavity shave marginsJohns Hopkins HospitalReoperation rateMargin statusSitu diseaseSurgical marginsMulticenter studyPostoperative histopathologyNegative marginsResultsA totalPatient outcomesSpecimen marginsBreast cancerMedical CenterMargin specimensBlinded studyTrends in Incident Hemodialysis Access and Mortality
Malas MB, Canner JK, Hicks CW, Arhuidese IJ, Zarkowsky DS, Qazi U, Schneider EB, Black JH, Segev DL, Freischlag JA. Trends in Incident Hemodialysis Access and Mortality. JAMA Surgery 2015, 150: 441-448. PMID: 25738981, DOI: 10.1001/jamasurg.2014.3484.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseHemodialysis cathetersArteriovenous fistulaArteriovenous graftsLower mortalityRenal diseaseVascular accessHD outcomesNational Kidney Foundation Kidney Disease Outcomes Quality InitiativeKidney Foundation Kidney Disease Outcomes Quality InitiativeMultivariable Cox proportional hazards modelsPrior renal replacement therapyUS Renal Data SystemCox proportional hazards modelArteriovenous fistula useIncident HD patientsInitiation of hemodialysisRetrospective cohort studyRenal replacement therapyProportional hazards modelFistula useCohort studySurvival benefitHD patientsPropensity score-matching techniqueUnconscious Race and Social Class Bias Among Acute Care Surgical Clinicians and Clinical Treatment Decisions
Haider A, Schneider E, Sriram N, Dossick D, Scott V, Swoboda S, Losonczy L, Haut E, Efron D, Pronovost P, Lipsett P, Cornwell E, MacKenzie E, Cooper L, Freischlag J. Unconscious Race and Social Class Bias Among Acute Care Surgical Clinicians and Clinical Treatment Decisions. JAMA Surgery 2015, 150: 457-464. PMID: 25786199, DOI: 10.1001/jamasurg.2014.4038.Peer-Reviewed Original ResearchConceptsClinical decisionMultivariable analysisUnconscious raceSurgical cliniciansSignificant health inequitiesLogistic regression analysisClinical treatment decisionsPatient care decisionsPatient management decisionsD scorePhysician-patient interactionDisadvantaged patientsPatient raceUnivariate analysisClinical assessmentCritical careTreatment decisionsMAIN OUTCOMELevel ISocial class biasWeb-based surveyClinician's roleHealth inequitiesCliniciansEmergency medicineClinical Presentation of Patients with a Thyroid Follicular Neoplasm: Are there Preoperative Predictors of Malignancy?
Najafian A, Olson M, Schneider E, Zeiger M. Clinical Presentation of Patients with a Thyroid Follicular Neoplasm: Are there Preoperative Predictors of Malignancy? Annals Of Surgical Oncology 2015, 22: 3007-3013. PMID: 25564170, DOI: 10.1245/s10434-014-4324-z.Peer-Reviewed Original ResearchConceptsMalignant follicular neoplasmsFollicular thyroid neoplasmFollicular neoplasmThyroid neoplasmsMalignant follicular thyroid neoplasmsFinal pathologic resultsPresentation of patientsHistory of headMultivariate logistic regressionOdds of malignancyPredictors of malignancyThyroid follicular neoplasmsFollicular thyroid lesionsConcomitant hyperthyroidismMethodsConsecutive patientsNeck radiationPreoperative predictorsClinical predictorsClinical featuresClinical presentationMale sexTertiary hospitalResultsA totalPhysical examinationPathologic results
2014
Variation in Readmission by Hospital After Colorectal Cancer Surgery
Lucas D, Ejaz A, Bischof D, Schneider E, Pawlik T. Variation in Readmission by Hospital After Colorectal Cancer Surgery. JAMA Surgery 2014, 149: 1272-1277. PMID: 25337956, DOI: 10.1001/jamasurg.2014.988.Peer-Reviewed Original ResearchConceptsReadmission ratesColorectal surgeryAppropriate risk adjustmentHierarchical multivariable logistic regression analysisMultivariable logistic regression analysisRisk-adjusted readmission ratesRisk adjustmentRepresentative cancer registryColorectal cancer surgeryEnd Results-MedicareHospital readmission ratesHospital quality metricsRisk-adjusted variationLogistic regression analysisColorectal resectionStudy patientsHospital readmissionMedian agePatient characteristicsCancer surgeryCancer RegistryMAIN OUTCOMEReadmissionUS hospitalsHospital
2013
Post-treatment surveillance of patients with colorectal cancer with surgically treated liver metastases
Hyder O, Dodson R, Mayo S, Schneider E, Weiss M, Herman J, Wolfgang C, Pawlik T. Post-treatment surveillance of patients with colorectal cancer with surgically treated liver metastases. Surgery 2013, 154: 256-265. PMID: 23889953, PMCID: PMC4048030, DOI: 10.1016/j.surg.2013.04.021.Peer-Reviewed Original ResearchConceptsColorectal liver metastasesMagnetic resonance imagingPositron emission tomographyPost-treatment surveillanceComputed tomographyLiver metastasesLiver resectionSurveillance imagingTreatment of CRLMMore frequent surveillanceMedian survival durationAbdominal computed tomographyPopulation-based patternsLong-term survivalIntensity of surveillanceOverall survivalMedian ageSurveillance guidelinesColorectal cancerMedicare databaseSecondary interventionsSurvival durationProcedure typeFrequent surveillanceHealthcare resources
2011
Long‐Term Outcome in Patients with Primary Hyperparathyroidism who Underwent Minimally Invasive Parathyroidectomy
Venkat R, Kouniavsky G, Tufano R, Schneider E, Dackiw A, Zeiger M. Long‐Term Outcome in Patients with Primary Hyperparathyroidism who Underwent Minimally Invasive Parathyroidectomy. World Journal Of Surgery 2011, 36: 55-60. PMID: 22089919, DOI: 10.1007/s00268-011-1344-8.Peer-Reviewed Original ResearchConceptsPrimary hyperparathyroidismBiochemical cureInvasive parathyroidectomySymptom resolutionHigh biochemical cure rateLong-term symptom resolutionIntraoperative PTH levelsParathyroid hormone levelsPAS scoresBiochemical cure ratesMean serum calciumLong-term outcomesMean PAS scoreParathyroidectomy assessmentPHPT patientsPTH levelsSestamibi scanPersistent diseaseRecurrent diseaseLong-term evaluationSerum calciumSymptom scoresTerm outcomesPreoperative localizationCure rateDifferential Association of Race With Treatment and Outcomes in Medicare Patients Undergoing Diverticulitis Surgery
Schneider EB, Haider A, Sheer AJ, Hambridge HL, Chang DC, Segal JB, Wu AW, Lidor AO. Differential Association of Race With Treatment and Outcomes in Medicare Patients Undergoing Diverticulitis Surgery. JAMA Surgery 2011, 146: 1272-1276. PMID: 22106319, DOI: 10.1001/archsurg.2011.280.Peer-Reviewed Original ResearchConceptsMedical comorbiditiesInsurance statusUrgent/emergency surgeryGreater riskRacial disparitiesUrgent/emergencyMedicare Provider AnalysisHealth insurance statusObserved racial disparitiesHospital mortalityGreater comorbidityEmergency surgerySurgical treatmentEmergency admissionsStudy criteriaBlack raceWorse outcomesMedicare patientsProcedure typeRetrospective analysisInpatient dataComorbiditiesMortality riskMultivariable regressionOutcome data