2016
Hospital readmission after multiple major operative procedures among patients with employer provided health insurance
Kim Y, Gani F, Canner J, Margonis G, Makary M, Schneider E, Pawlik T. Hospital readmission after multiple major operative procedures among patients with employer provided health insurance. Surgery 2016, 160: 178-190. PMID: 27085686, DOI: 10.1016/j.surg.2016.01.025.Peer-Reviewed Original ResearchConceptsMultiple operative proceduresDays of dischargeMajor operative proceduresOperative procedureSingle operative procedureIndex dischargeLate readmissionHospital readmissionMultivariable logistic regression analysisHigher preoperative comorbidityLate hospital readmissionLogistic regression analysisDuration of stayPreoperative comorbiditiesPostoperative complicationsPostoperative dischargeMarketScan databaseMultivariable analysisOverall incidenceAbdominal proceduresSame hospitalRisk factorsReadmissionCardiovascular proceduresGreater oddsAssociation of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers
Han PA, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, Thompson GB, Gauger PG, Somervell H, Bishop JA, Eshleman JR, Schneider EB, Witwer KW, Umbricht CB, Zeiger MA. Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers. Thyroid 2016, 26: 532-542. PMID: 26950846, PMCID: PMC4827320, DOI: 10.1089/thy.2015.0378.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionMultivariable logistic regression analysisPapillary thyroid cancerProphylactic central lymph node dissectionLogistic regression analysisLymph node dissectionAggressive clinicopathologic featuresLymph node metastasisEndocrine surgery centersStand-alone markerClinicopathologic featuresMiR-146bNode dissectionIndependent predictorsNode metastasisMiR-222Surgery centersThyroid cancerProphylactic lymph node dissectionRegression analysisIndividual prognostic markersOnly preoperative variablesNode-negative casesMicroRNA expression
2015
Early Versus Late Readmission After Surgery Among Patients With Employer-provided Health Insurance
Kim Y, Gani F, Lucas D, Ejaz A, Spolverato G, Canner J, Schneider E, Pawlik T. Early Versus Late Readmission After Surgery Among Patients With Employer-provided Health Insurance. Annals Of Surgery 2015, 262: 502-511. PMID: 26258319, DOI: 10.1097/sla.0000000000001429.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAgedCohort StudiesDatabases, FactualFemaleHealth Benefit Plans, EmployeeHealth Care CostsHospital CostsHumansLength of StayLogistic ModelsMaleMiddle AgedMultivariate AnalysisPatient DischargePatient ReadmissionRetrospective StudiesSurgical Procedures, OperativeTime FactorsConceptsNon-index hospitalsDays of dischargeMajor surgical proceduresSame-hospital readmissionsLate readmissionIndex hospitalHospital readmissionSurgical proceduresTruven Health MarketScan Commercial ClaimsMultivariable logistic regression analysisCharlson Comorbidity IndexMarketScan Commercial ClaimsLogistic regression analysisHospital mortalityComorbidity indexIndex dischargeEarly readmissionTrue incidenceEncounters DatabaseCommercial ClaimsReadmissionPatientsDifferent hospitalsHospitalHealth insuranceUnconscious Race and Social Class Bias Among Acute Care Surgical Clinicians and Clinical Treatment Decisions
Haider A, Schneider E, Sriram N, Dossick D, Scott V, Swoboda S, Losonczy L, Haut E, Efron D, Pronovost P, Lipsett P, Cornwell E, MacKenzie E, Cooper L, Freischlag J. Unconscious Race and Social Class Bias Among Acute Care Surgical Clinicians and Clinical Treatment Decisions. JAMA Surgery 2015, 150: 457-464. PMID: 25786199, DOI: 10.1001/jamasurg.2014.4038.Peer-Reviewed Original ResearchConceptsClinical decisionMultivariable analysisUnconscious raceSurgical cliniciansSignificant health inequitiesLogistic regression analysisClinical treatment decisionsPatient care decisionsPatient management decisionsD scorePhysician-patient interactionDisadvantaged patientsPatient raceUnivariate analysisClinical assessmentCritical careTreatment decisionsMAIN OUTCOMELevel ISocial class biasWeb-based surveyClinician's roleHealth inequitiesCliniciansEmergency medicineDo trauma center levels matter in older isolated hip fracture patients?
Nelson-Williams H, Kodadek L, Canner J, Schneider E, Efron D, Haut E, Shafiq B, Haider A, Velopulos CG. Do trauma center levels matter in older isolated hip fracture patients? Journal Of Surgical Research 2015, 198: 468-474. PMID: 26038246, DOI: 10.1016/j.jss.2015.03.074.Peer-Reviewed Original ResearchConceptsHip fracture patientsLevel trauma centerTrauma center levelFracture patientsTrauma centerDischarge dispositionUnadjusted logistic regression analysisNationwide Emergency Department SampleHigh-level trauma centersLower level trauma centerIsolated hip fractureHospital-level factorsOdds of dischargeOdds of mortalityHospital-level variablesMulti-trauma patientsMultivariable logistic regressionEmergency Department SampleMain outcome measuresLogistic regression analysisCenter levelInhospital mortalityOlder patientsRetrospective cohortHip fractureNational estimates of predictors of outcomes for emergency general surgery
Shah AA, Haider AH, Zogg CK, Schwartz DA, Haut ER, Zafar SN, Schneider EB, Velopulos CG, Shafi S, Zafar H, Efron DT. National estimates of predictors of outcomes for emergency general surgery. Journal Of Trauma And Acute Care Surgery 2015, 78: 482-491. PMID: 25710417, DOI: 10.1097/ta.0000000000000555.Peer-Reviewed Original ResearchConceptsEmergency general surgeryEGS patientsMajor complicationsGeneral surgeryMultivariate logistic regression analysisOverall complication ratePredictors of mortalityClinical Modification codesOverall mortality rateNationwide Inpatient SampleSeparate multivariate logistic regression analysesSurgery of TraumaDRG International ClassificationLogistic regression analysisHighest income quartileHospital complicationsHospital mortalityComplication ratePatient demographicsSurgical complicationsIndependent predictorsPrimary outcomeEGS conditionsMean ageInpatient SampleTraumatic brain injury in the elderly: morbidity and mortality trends and risk factors
Haring R, Narang K, Canner J, Asemota A, George B, Selvarajah S, Haider A, Schneider E. Traumatic brain injury in the elderly: morbidity and mortality trends and risk factors. Journal Of Surgical Research 2015, 195: 1-9. PMID: 25724764, DOI: 10.1016/j.jss.2015.01.017.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryMechanism of injuryBrain injuryTBI-related deathsTBI-related hospitalizationOdds of deathMultivariable logistic regressionNationwide Inpatient SampleLogistic regression analysisOlder age groupsMore comorbiditiesMale patientsPayer statusTBI patientsInpatient SampleRisk factorsHigher oddsInjury severityPatientsMortality trendsAge groupsInjuryLogistic regressionTBI dataComorbidities
2014
Variation in Readmission by Hospital After Colorectal Cancer Surgery
Lucas D, Ejaz A, Bischof D, Schneider E, Pawlik T. Variation in Readmission by Hospital After Colorectal Cancer Surgery. JAMA Surgery 2014, 149: 1272-1277. PMID: 25337956, DOI: 10.1001/jamasurg.2014.988.Peer-Reviewed Original ResearchConceptsReadmission ratesColorectal surgeryAppropriate risk adjustmentHierarchical multivariable logistic regression analysisMultivariable logistic regression analysisRisk-adjusted readmission ratesRisk adjustmentRepresentative cancer registryColorectal cancer surgeryEnd Results-MedicareHospital readmission ratesHospital quality metricsRisk-adjusted variationLogistic regression analysisColorectal resectionStudy patientsHospital readmissionMedian agePatient characteristicsCancer surgeryCancer RegistryMAIN OUTCOMEReadmissionUS hospitalsHospitalUnconscious race and class bias
Haider A, Schneider E, Sriram N, Dossick D, Scott V, Swoboda S, Losonczy L, Haut E, Efron D, Pronovost P, Freischlag J, Lipsett P, Cornwell E, MacKenzie E, Cooper L. Unconscious race and class bias. Journal Of Trauma And Acute Care Surgery 2014, 77: 409-416. PMID: 25159243, DOI: 10.1097/ta.0000000000000392.Peer-Reviewed Original ResearchConceptsAcute care surgeonsSurgery of TraumaClinical decisionTrauma/acute care surgeonsEastern AssociationImplicit Association TestUnconscious raceProspective web-based surveyPhysicians' clinical decisionsLogistic regression analysisSurgeons' clinical decisionClinical vignettesImplicit biasesIAT scoresUnconscious preferenceMultivariable analysisPatient raceRace Implicit Association TestUnivariate analysisClinical assessmentPatient managementEpidemiologic studiesWeb-based surveyLevel IIWhite personsDeveloping best practices to study trauma outcomes in large databases
Haider A, Hashmi Z, Zafar S, Castillo R, Haut E, Schneider E, Cornwell E, Mackenzie E, Efron D. Developing best practices to study trauma outcomes in large databases. Journal Of Trauma And Acute Care Surgery 2014, 76: 1061-1069. PMID: 24662872, DOI: 10.1097/ta.0000000000000182.Peer-Reviewed Original ResearchConceptsNational Trauma Data BankRisk-adjustment modelsTrauma mortalityTrauma outcomesSubsequent multivariate logistic regression analysisMultivariate logistic regression analysisManual backward selectionTrauma Data BankUnivariate logistic regressionLogistic regression analysisInitial multivariate modelPatient subsetsMultivariable analysisTrauma centerMortality outcomesSimilar AUROCsSubset analysisUnivariate analysisPrognostic studiesAnalytic standardizationLevel IIILogistic regression
2013
Socioeconomic disparity in inpatient mortality after traumatic injury in adults
Ali M, Hui X, Hashmi Z, Dhiman N, Scott V, Efron D, Schneider E, Haider A. Socioeconomic disparity in inpatient mortality after traumatic injury in adults. Surgery 2013, 154: 461-467. PMID: 23972652, PMCID: PMC3989530, DOI: 10.1016/j.surg.2013.05.036.Peer-Reviewed Original ResearchConceptsInjury Severity ScoreInpatient mortalityMedian household incomeSocioeconomic statusTrauma mortalityInsurance statusMultiple logistic regression analysisUnadjusted inpatient mortalityNationwide Inpatient SampleType of injuryLogistic regression analysisLower wealth quartilesWealthiest quartileTrauma disparitiesPatient demographicsIndependent predictorsTrauma patientsSeverity scoreAdjusted oddsInpatient SampleTraumatic injuryInclusion criteriaAdult traumaComorbiditiesMortalityPredictors of outcome in acute encephalitis
Thakur K, Motta M, Asemota A, Kirsch H, Benavides D, Schneider E, McArthur J, Geocadin R, Venkatesan A. Predictors of outcome in acute encephalitis. Neurology 2013, 81: 793-800. PMID: 23892708, PMCID: PMC3908458, DOI: 10.1212/wnl.0b013e3182a2cc6d.Peer-Reviewed Original ResearchConceptsMultivariate logistic regression analysisPredictors of outcomeStatus epilepticusLogistic regression analysisCerebral edemaHospital dischargePoor outcomeJohns Hopkins Bayview Medical CenterPredictors of deathFurther prospective studiesIntensive care unitJohns Hopkins HospitalRegression analysisIntubation requirementAutoimmune etiologyAcute encephalitisAggressive managementVentilator supportMedian ageCare unitViral encephalitisProspective studyEncephalitis casesUnknown causeRetrospective analysis
2012
Is BRAF mutation associated with lymph node metastasis in patients with papillary thyroid cancer?
Lee K, Li C, Schneider E, Wang Y, Somervell H, Krafft M, Umbricht C, Zeiger M. Is BRAF mutation associated with lymph node metastasis in patients with papillary thyroid cancer? Surgery 2012, 152: 977-983. PMID: 23062653, PMCID: PMC3715093, DOI: 10.1016/j.surg.2012.08.019.Peer-Reviewed Original ResearchConceptsCentral lymph node dissectionLymph node metastasisPapillary thyroid cancerBRAF mutation statusMutation statusBRAF mutationsNode metastasisSurgical managementClinicopathologic featuresThyroid cancerPresence of LNMRoutine central lymph node dissectionMultivariate logistic regression analysisLymph node dissectionAggressive clinicopathologic featuresInstitutional review board approvalLogistic regression analysisFine-needle aspirationFine-needle aspiration samplesReview board approvalNode dissectionTotal thyroidectomyLymphatic invasionChi-square analysisBoard approval