2018
Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1
Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, DeWan AT, Triche EW, Saftlas AF, Hoh J, Bodian DL, Klein E, Huddleston KC, Ingles SA, Lockwood CJ, Hakonarson H, McElrath TF, Murray JC, Wilson ML, Norwitz ER, Karumanchi SA, Bateman BT, Keating BJ, Saxena R. Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1. Hypertension 2018, 72: 408-416. PMID: 29967039, PMCID: PMC6043396, DOI: 10.1161/hypertensionaha.117.10688.Peer-Reviewed Original Research
2016
Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia
Spracklen CN, Smith CJ, Saftlas AF, Triche EW, Bjonnes A, Keating BJ, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia. Hypertension In Pregnancy 2016, 36: 30-35. PMID: 27657194, PMCID: PMC5538572, DOI: 10.1080/10641955.2016.1223303.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersBlood PressureC-Reactive ProteinFemaleGenetic Association StudiesGenetic LociGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotidePre-EclampsiaPregnancyRisk FactorsConceptsC-reactive proteinGenetic risk scoreRisk of preeclampsiaBody mass indexGenetic predispositionCRP levelsPreeclampsia casesRisk scoreCRP genetic risk scoreElevated C-reactive proteinLeisure-time physical activityBlood CRP levelsIndependent replication populationMarkers of preeclampsiaElevated levelsMedical chart reviewLive birth certificatesLogistic regression analysisInverse linear trendChart reviewIowa womenNormotensive controlsDecreased riskMass indexPhysical activity
2015
Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia
Smith CJ, Saftlas AF, Spracklen CN, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia. American Journal Of Hypertension 2015, 29: 17-24. PMID: 26002928, PMCID: PMC4692983, DOI: 10.1093/ajh/hpv069.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureSystolic blood pressureGenetic risk scoreRisk of preeclampsiaBlood pressureEssential hypertensionRisk scoreNormotensive pregnant controlsHypertensive complicationsArterial pressurePregnant controlsWeeks' gestationPreeclamptic casesHypertensive stateEpidemiological evidenceHypertensionPreeclampsiaUS populationNonsignificant associationGenetic risk lociGenetic susceptibilitySwab samplesBuccal swab samplesGenetic riskRegression analysis
2014
Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia
Spracklen CN, Saftlas AF, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia. American Journal Of Hypertension 2014, 28: 915-923. PMID: 25523295, PMCID: PMC4542907, DOI: 10.1093/ajh/hpu242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlood PressureCase-Control StudiesChi-Square DistributionCholesterol, HDLCholesterol, LDLDyslipidemiasFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIowaLogistic ModelsMultivariate AnalysisOdds RatioPhenotypePolymorphism, Single NucleotidePre-EclampsiaPregnancyRisk FactorsTriglyceridesYoung AdultBioinformatic Approach to the Genetics of Preeclampsia
Triche EW, Uzun A, DeWan AT, Kurihara I, Liu J, Occhiogrosso R, Shen B, Parker J, Padbury JF. Bioinformatic Approach to the Genetics of Preeclampsia. Obstetrics And Gynecology 2014, 123: 1155-1161. PMID: 24807322, PMCID: PMC4409136, DOI: 10.1097/aog.0000000000000293.Peer-Reviewed Original ResearchComputational BiologyData MiningFemaleGene OntologyGenetic Predisposition to DiseaseHELLP SyndromeHumansNatural Language ProcessingPhenotypePre-EclampsiaPregnancy
2013
Intellectual Disability Is Associated with Increased Runs of Homozygosity in Simplex Autism
Gamsiz ED, Viscidi EW, Frederick AM, Nagpal S, Sanders SJ, Murtha MT, Schmidt M, Consortium S, Triche EW, Geschwind DH, State MW, Istrail S, Cook EH, Devlin B, Morrow EM. Intellectual Disability Is Associated with Increased Runs of Homozygosity in Simplex Autism. American Journal Of Human Genetics 2013, 93: 103-109. PMID: 23830515, PMCID: PMC3710760, DOI: 10.1016/j.ajhg.2013.06.004.Peer-Reviewed Original ResearchConceptsGenome-wide analysisRare deleterious variantsDistinct genetic architecturesAutism candidate genesExome sequence dataGenetic architectureSingle geneROH burdenCandidate genesDeleterious variantsAutosomal recessive mutationSimplex autismGenesProportion of femalesIntellectual disabilityHomozygosityFamilyLociUnaffected siblingsMutationsAutism spectrum disorderFemalesProbandsVariants
2012
Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients
Zhao L, Triche EW, Walsh KM, Bracken MB, Saftlas AF, Hoh J, Dewan AT. Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients. BMC Pregnancy And Childbirth 2012, 12: 61. PMID: 22748001, PMCID: PMC3476390, DOI: 10.1186/1471-2393-12-61.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCopy number variantsSingle nucleotide polymorphismsSNP candidatesCopy number deletionAssociation studiesGenome-wide scanLimited DNA quantitiesQuantitative real-time PCRAffymetrix SNP 6.0 microarraysGenomic regionsOnly deletionPSG11 geneReal-time PCRDeleterious natureMaternal single nucleotide polymorphismsNucleotide polymorphismsGenetic contributionDeletionDNA quantityCase-control datasetSignificance thresholdCNV callsPSG11Genes
2011
Association of variants in innate immune genes with asthma and eczema
Sharma S, Poon A, Himes BE, Lasky‐Su J, Sordillo JE, Belanger K, Milton DK, Bracken MB, Triche EW, Leaderer BP, Gold DR, Litonjua AA. Association of variants in innate immune genes with asthma and eczema. Pediatric Allergy And Immunology 2011, 23: 315-323. PMID: 22192168, PMCID: PMC3412627, DOI: 10.1111/j.1399-3038.2011.01243.x.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAsthmaBayes TheoremChild, PreschoolEczemaFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansImmunity, InnateMalePolymorphism, Single NucleotideConceptsInnate immune genesPathogenesis of asthmaInnate immune pathwaysSingle nucleotide polymorphismsAsthma StudyImmune genesImmune pathwaysChildhood Asthma StudyPolymorphisms of genesAssociation of variantsChildhood asthmaEczema riskAsthmaCase controlEczemaImmune variantsAdditional single nucleotide polymorphismsBayesian network analysisHome allergensScreening algorithmDifferent genetic determinantsTop single nucleotide polymorphismsPathogenesisMultiple comparisonsDisease susceptibilityEffects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1
Sordillo JE, Sharma S, Poon A, Lasky-Su J, Belanger K, Milton DK, Bracken MB, Triche EW, Leaderer BP, Gold DR, Litonjua AA. Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1. BMC Medical Genomics 2011, 12: 158. PMID: 22151743, PMCID: PMC3252252, DOI: 10.1186/1471-2350-12-158.Peer-Reviewed Original ResearchConceptsEndotoxin exposureAsthma riskProtective effectRisk of asthmaGenetic polymorphismsChildhood asthma riskChildhood Asthma StudyInnate immune pathwaysInnate immunity pathwaysAsthma StudyAsthmaConclusionOur findingsImmune pathwaysMinor alleleHome allergensImmunity pathwaysEczemaMajor alleleChildrenEndotoxinExposureRiskSignificant interactionPolymorphismACAA1
2007
Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes
Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP. Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes. BMC Medical Genomics 2007, 8: 15. PMID: 17407567, PMCID: PMC1852548, DOI: 10.1186/1471-2350-8-15.Peer-Reviewed Original ResearchConceptsPersistent coughSurfactant protein ARespiratory symptomsWhite infantsClinician-diagnosed asthmaInfant respiratory symptomsRespiratory symptom frequencyRisk of wheezeCohort of infantsSingle nucleotide polymorphismsMonths of ageQuarterly telephone interviewsLogistic regression modelsRace/ethnicityStudy infantsNewborn infantsSymptom frequencyInfant's birthStandardized questionnaireCoughWheezeAsthmaInfantsTelephone interviewsOlder children
2006
Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma
Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP. Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma. BMC Medical Genomics 2006, 7: 68. PMID: 16884531, PMCID: PMC1557482, DOI: 10.1186/1471-2350-7-68.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAsthmaFemaleGenetic Predisposition to DiseaseHaplotypesHumansInfantMaleOtitis MediaPolymorphism, Single NucleotidePulmonary Surfactant-Associated Protein ARiskWhite PeopleConceptsOtitis mediaWhite infantsInfant respiratory symptomsPhysician-diagnosed asthmaCohort of infantsLarger confirmatory studiesSurfactant proteinsInnate immune responseMonths of ageQuarterly telephone interviewsLogistic regression modelsRace/ethnicityRespiratory symptomsCommon infectionsProspective studyImmune responseStudy populationInfant's birthStandardized questionnaireInfantsConclusionThese resultsAsthmaTelephone interviewsConfirmatory studiesWhole blood
2005
Immunogenetic Determinants of Preeclampsia and Related Pregnancy Disorders
Saftlas A, Beydoun H, Triche E. Immunogenetic Determinants of Preeclampsia and Related Pregnancy Disorders. Obstetrics And Gynecology 2005, 106: 162-172. PMID: 15994633, DOI: 10.1097/01.aog.0000167389.97019.37.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesFemaleFetal Growth RetardationGenetic Predisposition to DiseaseHLA AntigensHLA-DR AntigensHumansImmunogeneticsMaternal AgeParityPre-EclampsiaPregnancyPrognosisRisk FactorsSensitivity and SpecificityConceptsIntrauterine growth restrictionRisk of preeclampsiaGrowth restrictionHuman leukocyte antigen (HLA) allele frequenciesMaternal homozygosityPossible etiologic factorsHLA-DR locusSpecific HLA allelesAdditional pertinent studiesBasic science research studiesHLA allele frequenciesImmunogenetic factorsOriginal research studiesExposure definitionPregnancy disordersEtiologic factorsHLA genotypeSTUDY SELECTIONHLA sharingImmunogenetic determinantsPreeclampsiaHLA allelesPubMed databaseYielded inconsistent resultsComputerized search
2002
Genetic and Perinatal Risk Factors for Asthma Onset and Severity: A Review and Theoretical Analysis
Bracken MB, Belanger K, Cookson WO, Triche E, Christiani DC, Leaderer BP. Genetic and Perinatal Risk Factors for Asthma Onset and Severity: A Review and Theoretical Analysis. Epidemiologic Reviews 2002, 24: 176-189. PMID: 12762091, DOI: 10.1093/epirev/mxf012.Peer-Reviewed Original Research