2011
Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1
Sordillo JE, Sharma S, Poon A, Lasky-Su J, Belanger K, Milton DK, Bracken MB, Triche EW, Leaderer BP, Gold DR, Litonjua AA. Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1. BMC Medical Genomics 2011, 12: 158. PMID: 22151743, PMCID: PMC3252252, DOI: 10.1186/1471-2350-12-158.Peer-Reviewed Original ResearchConceptsEndotoxin exposureAsthma riskProtective effectRisk of asthmaGenetic polymorphismsChildhood asthma riskChildhood Asthma StudyInnate immune pathwaysInnate immunity pathwaysAsthma StudyAsthmaConclusionOur findingsImmune pathwaysMinor alleleHome allergensImmunity pathwaysEczemaMajor alleleChildrenEndotoxinExposureRiskSignificant interactionPolymorphismACAA1
2009
Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children
Bundy KW, Gent JF, Beckett W, Bracken MB, Belanger K, Triche E, Leaderer BP. Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children. Annals Of Allergy Asthma & Immunology 2009, 103: 26-30. PMID: 19663123, PMCID: PMC2746059, DOI: 10.1016/s1081-1206(10)60139-1.Peer-Reviewed Original ResearchConceptsPeak expiratory flow variabilityExpiratory flow variabilityAsthmatic childrenAirway hyperreactivityPeak expiratory flowYears of ageLogistic regression modelsAsthma prevalencePhysician diagnosisExpiratory flowChildren 6HyperreactivityChildrenAirborne mold concentrationsRegression modelsAgeCommon moldsIndoor fungiExposureMold concentrationsHomeAsthmaAirborne fungiTotal moldPrevalenceSymptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution
Gent JF, Koutrakis P, Belanger K, Triche E, Holford TR, Bracken MB, Leaderer BP. Symptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution. Environmental Health Perspectives 2009, 117: 1168-1174. PMID: 19654929, PMCID: PMC2717146, DOI: 10.1289/ehp.0800335.Peer-Reviewed Original ResearchConceptsMedication useInhaler useLikelihood of wheezeExacerbation of asthmaMeasures logistic regression modelsRisk of symptomsRespiratory health effectsYears of ageHealth outcomes riskLikelihood of symptomsLogistic regression modelsAsthma 4Outcome riskAsthmaHealth outcomesDaily exposureSymptomsHealth effectsStudy diariesParticle exposureHealth impactsChildrenPublic healthExposureRegression models
2004
Exposure to NO2 and Nitrous Acid and Respiratory Symptoms in the First Year of Life
van Strien RT, Gent JF, Belanger K, Triche E, Bracken MB, Leaderer BP. Exposure to NO2 and Nitrous Acid and Respiratory Symptoms in the First Year of Life. Epidemiology 2004, 15: 471-478. PMID: 15232409, DOI: 10.1097/01.ede.0000129511.61698.d8.Peer-Reviewed Original Research
2003
Association of Low-Level Ozone and Fine Particles With Respiratory Symptoms in Children With Asthma
Gent JF, Triche EW, Holford TR, Belanger K, Bracken MB, Beckett WS, Leaderer BP. Association of Low-Level Ozone and Fine Particles With Respiratory Symptoms in Children With Asthma. JAMA 2003, 290: 1859-1867. PMID: 14532314, DOI: 10.1001/jama.290.14.1859.Peer-Reviewed Original ResearchConceptsRescue medication useRespiratory symptomsDaily respiratory symptomsMedication useMaintenance medicationLikelihood of wheezeShortness of breathLogistic regression analysisRescue medicationChest tightnessActive asthmaAsthmatic childrenMedication usersRisk factorsAsthmaMedicationsSymptomsMean levelsSubject's motherChildrenRegression analysisAssociationExposureMothersHigh levelsSymptoms of Wheeze and Persistent Cough in the First Year of Life: Associations with Indoor Allergens, Air Contaminants, and Maternal History of Asthma
Belanger K, Beckett W, Triche E, Bracken MB, Holford T, Ren P, McSharry JE, Gold DR, Platts-Mills TA, Leaderer BP. Symptoms of Wheeze and Persistent Cough in the First Year of Life: Associations with Indoor Allergens, Air Contaminants, and Maternal History of Asthma. American Journal Of Epidemiology 2003, 158: 195-202. PMID: 12882940, DOI: 10.1093/aje/kwg148.Peer-Reviewed Original ResearchConceptsInfants of mothersSymptoms of wheezePersistent coughPhysician-diagnosed asthmaDust mite allergenRelation of exposureFirst yearAsthma historyDog allergensIndoor allergensInfant wheezeMaternal historyMite allergensCoughWheezeHome exposureAsthmaInfantsAllergensSymptomsAsthmatic siblingsMothersExposureRiskFirst study
1999
Healthy Women's PEF Variations with Ambient Summer Concentrations of PM10, PM2.5, SO4 2 −, H+, and O3
NAEHER L, HOLFORD T, BECKETT W, BELANGER K, TRICHE E, BRACKEN M, LEADERER B. Healthy Women's PEF Variations with Ambient Summer Concentrations of PM10, PM2.5, SO4 2 −, H+, and O3. American Journal Of Respiratory And Critical Care Medicine 1999, 160: 117-125. PMID: 10390388, DOI: 10.1164/ajrccm.160.1.9808153.Peer-Reviewed Original ResearchConceptsPeak expiratory flowPEF variationEvening peak expiratory flowMorning peak expiratory flowOutdoor monitoring sitePeak flow meterAmbient air pollutionMicrograms/m3Expiratory flowPhysiologic effectsPEF measurementsOnly exposureConcurrent measuresExposureMeteorologic variablesFine particulate sulfateDaily