2019
Norovirus Changes Susceptibility to Type 1 Diabetes by Altering Intestinal Microbiota and Immune Cell Functions
Pearson JA, Tai N, Ekanayake-Alper DK, Peng J, Hu Y, Hager K, Compton S, Wong FS, Smith PC, Wen L. Norovirus Changes Susceptibility to Type 1 Diabetes by Altering Intestinal Microbiota and Immune Cell Functions. Frontiers In Immunology 2019, 10: 2654. PMID: 31798584, PMCID: PMC6863139, DOI: 10.3389/fimmu.2019.02654.Peer-Reviewed Original ResearchConceptsExpansion of TregsNOD miceT cellsMNV4 infectionMucosal immunityNon-obese diabetic (NOD) mouse modelGerm-free NOD miceFirmicutes/Bacteroidetes ratioProinflammatory T cellsRole of norovirusesTuft cell markersDevelopment of T1DInflammatory T cellsCommon enteric virusesB cell subsetsDiabetic mouse modelImmune cell functionType 1 diabetes susceptibilityEnteric virusesNaïve splenocytesT1D protectionTreg numbersImmunological changesMucosal antibodiesT1D development
2018
Retrospective Review of Surgical Outcomes and Pair-housing Success in Vasectomized Rhesus Macaques (Macaca mulatta).
Ekanayake-Alper DK, Wilson SR, Scholz JA. Retrospective Review of Surgical Outcomes and Pair-housing Success in Vasectomized Rhesus Macaques (Macaca mulatta). Comparative Medicine 2018, 68: 168-176. PMID: 29663943, PMCID: PMC5897974.Peer-Reviewed Original ResearchConceptsAdult male macaquesPostoperative complicationsRetrospective reviewSurgical outcomesRhesus macaquesMale macaquesSurgical site infectionFemale partnersAdult rhesus macaquesAdult male rhesus macaquesMale rhesus macaquesIncisional swellingAnalgesic therapyComplication rateNSAID treatmentSite infectionBenign complicationComplicationsInvasive methodSperm granulomaUnwanted breeding