Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis?
Kumar D, Hafez O, Jain D, Zhang X. Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis? Human Pathology 2021, 113: 39-46. PMID: 33905775, DOI: 10.1016/j.humpath.2021.04.008.Peer-Reviewed Original ResearchConceptsMetastatic hepatocellular carcinomaHepatocellular carcinomaHistologic patternHistomorphologic featuresPrimary tumorMetastatic tumorsMacrotrabecular-massive hepatocellular carcinomaCommon histologic patternPathogenesis of metastasisSignificant intratumoral heterogeneityExtrahepatic metastasesLymph nodesMicrovascular invasionAdrenal glandCommon subtypeNoncirrhotic liverCirrhotic liverCommon siteMetastatic tissuesLarge cohortAbdominal cavityHCC subtypesPathology archivesMetastasisHCC metastasisBenign lymph node microenvironment is associated with response to immunotherapy
Toki MI, Kumar D, Ahmed FS, Rimm DL, Xu ML. Benign lymph node microenvironment is associated with response to immunotherapy. Precision Clinical Medicine 2020, 3: 44-53. PMID: 35693430, PMCID: PMC8985791, DOI: 10.1093/pcmedi/pbaa003.Peer-Reviewed Original ResearchBenign lymph nodesLymph nodesT cellsQuantitative immunofluorescenceBenign lymphPD-L1Immune checkpoint blockade therapyMultiplexed quantitative immunofluorescenceHigh expressionCheckpoint blockade therapyMacrophage marker expressionSignificant differencesCytotoxic markersBlockade therapyBenign findingsCancer patientsLymphoid tissueImmune surveillanceTreatment responsePostmortem examinationImmunotherapyProliferation indexSplenic tissueB cellsPatients