2022
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs
Carvelli A, Setti A, Desideri F, Galfrè SG, Biscarini S, Santini T, Colantoni A, Peruzzi G, Marzi MJ, Capauto D, Di Angelantonio S, Ballarino M, Nicassio F, Laneve P, Bozzoni I. A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs. The EMBO Journal 2022, 41: embj2021108918. PMID: 35698802, PMCID: PMC9251839, DOI: 10.15252/embj.2021108918.Peer-Reviewed Original ResearchConceptsMN differentiationPost-transcriptional roleSingle-cell sequencingMotor neuron differentiationPostmitotic motor neuronsTranscriptional unitsMESC differentiationTranscription factorsCRISPR/Transcriptional levelMiR-466iNeuron differentiationNeuronal differentiationFunctional relevanceMotor neuronsMiR-384-5pDifferentiationSeries of eventsProliferation-related factorsAdditional layerMutantsMiRNAsLncRNAsLociRNA
2018
Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALS
Biscarini S, Capauto D, Peruzzi G, Lu L, Colantoni A, Santini T, Shneider NA, Caffarelli E, Laneve P, Bozzoni I. Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALS. Stem Cell Research 2018, 27: 172-179. PMID: 29449089, DOI: 10.1016/j.scr.2018.01.037.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsCell DifferentiationHumansMiceMotor NeuronsRNA, Long NoncodingTranscriptomeConceptsLong non-coding transcriptomeMouse motor neuronsAmyotrophic lateral sclerosisNon-coding transcriptomeMotor neuronsSevere amyotrophic lateral sclerosisAberrant RNA metabolismLong non-coding RNAsStem cellsEmbryonic stem cellsNon-coding RNAsInduced pluripotent stem cellsNervous system developmentPluripotent stem cellsRNA metabolismLncRNA transcriptomeDifferentiation systemLateral sclerosisTDP-43TranscriptomeFUS-ALSCandidate lncRNAsCrucial playersCausative mutationsEssential role