2002
Brain-Derived Neurotrophic Factor: A Novel Human Ovarian Follicular Protein
Seifer DB, Feng B, Shelden RM, Chen S, Dreyfus CF. Brain-Derived Neurotrophic Factor: A Novel Human Ovarian Follicular Protein. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 655-659. PMID: 11836300, DOI: 10.1210/jcem.87.2.8213.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorOocyte maturationSecretion of BDNFSource of BDNFNervous systemRelease of BDNFSoluble polypeptide growth factorsHuman ovarian folliclesHuman follicular fluidCumulus granulosa cellsMammalian nervous systemFollicular proteinsBDNF receptorOocyte retrievalBDNF proteinTrk BNeurotrophic factorPolypeptide growth factorsHuman ovaryMural granulosaFollicular fluidMouse oocyte maturationOvarian folliclesGranulosa cellsEndocrine tissues
1998
Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes
Whitacre K, Seifer D, Friedman C, Coskun S, Kennard E, Kim M, Alak B. Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes. Fertility And Sterility 1998, 70: 1015-1021. PMID: 9848288, DOI: 10.1016/s0015-0282(98)00339-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgingCell CycleCell NucleusCells, CulturedCellular SenescenceFemaleFertilization in VitroHumansMenstrual CycleOocytesOvaryConceptsGerminal vesicle breakdownOvarian sourceNuclear maturationPatient ageGynecologic surgeryFollicular phaseLuteal phaseImmature human oocytesFinal meiotic maturationMenstrual cycle phaseYears of agePercentage of oocytesCycle phaseMetaphase II stageIVF programMenstrual cyclePatient criteriaMAIN OUTCOMEVitro maturationPatientsHuman oocytesOocyte maturationMII stageOocyte's abilityVesicle breakdownActivin a stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro
Alak B, Coskun S, Friedman C, Kennard E, Kim M, Seifer D. Activin a stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro. Fertility And Sterility 1998, 70: 1126-1130. PMID: 9848305, DOI: 10.1016/s0015-0282(98)00386-0.Peer-Reviewed Original ResearchConceptsGranulosa cell steroidogenesisGerminal vesicle breakdownGranulosa cellsActivin AE2 secretionSteroid secretionCell steroidogenesisNonluteinized granulosa cellsMeiotic maturationMetaphase IIUniversity Medical CenterAntral granulosa cellsNonovarian pathologyInhibin AMedical CenterMAIN OUTCOMEActivin A.Oocyte meiotic maturationImmature oocytesHuman oocytesOocyte maturationSecretionVesicle breakdownProgesteroneSteroidogenesis