2018
Vitamin D3 Regulates Follicular Development and Intrafollicular Vitamin D Biosynthesis and Signaling in the Primate Ovary
Xu J, Lawson MS, Xu F, Du Y, Tkachenko OY, Bishop CV, Pejovic-Nezhat L, Seifer DB, Hennebold JD. Vitamin D3 Regulates Follicular Development and Intrafollicular Vitamin D Biosynthesis and Signaling in the Primate Ovary. Frontiers In Physiology 2018, 09: 1600. PMID: 30487754, PMCID: PMC6246691, DOI: 10.3389/fphys.2018.01600.Peer-Reviewed Original ResearchVitamin D receptorVitamin D biosynthesisAntral folliclesVD3 supplementationFollicular developmentVitamin DAntral stagePrimate ovaryFollicle survivalVitamin D3D biosynthesisIsolated secondary folliclesOvarian follicle survivalOocyte maturationAnti-Müllerian hormone productionAdult rhesus macaquesParacrine factor productionStage-dependent mannerVD3 treatmentVDR expressionAMH productionDihydroxyvitamin D3Positive immunostainingD receptorProtein localization
2002
Neurotrophin-4/5 and Neurotrophin-3 Are Present within the Human Ovarian Follicle but Appear to Have Different Paracrine/Autocrine Functions
Seifer DB, Feng B, Shelden RM, Chen S, Dreyfus CF. Neurotrophin-4/5 and Neurotrophin-3 Are Present within the Human Ovarian Follicle but Appear to Have Different Paracrine/Autocrine Functions. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 4569-4571. PMID: 12364436, DOI: 10.1210/jc.2002-020499.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorNeurotrophin-3Human ovarian folliclesNT-4/5Follicular fluidOvarian folliclesNeurotrophin-4/5Paracrine/autocrine functionsTrk C receptorOocyte maturationSoluble polypeptide growth factorsFollicles of womenFollicular fluid samplesHuman follicular fluid samplesHuman follicular fluidPolar body extrusionMouse immature oocytesMammalian nervous systemMouse oocytesBDNF receptorTrk BNeurotrophic factorPolypeptide growth factorsFirst polar body extrusionNeurotrophin ligandsBrain-Derived Neurotrophic Factor: A Novel Human Ovarian Follicular Protein
Seifer DB, Feng B, Shelden RM, Chen S, Dreyfus CF. Brain-Derived Neurotrophic Factor: A Novel Human Ovarian Follicular Protein. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 655-659. PMID: 11836300, DOI: 10.1210/jcem.87.2.8213.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorOocyte maturationSecretion of BDNFSource of BDNFNervous systemRelease of BDNFSoluble polypeptide growth factorsHuman ovarian folliclesHuman follicular fluidCumulus granulosa cellsMammalian nervous systemFollicular proteinsBDNF receptorOocyte retrievalBDNF proteinTrk BNeurotrophic factorPolypeptide growth factorsHuman ovaryMural granulosaFollicular fluidMouse oocyte maturationOvarian folliclesGranulosa cellsEndocrine tissues
1998
Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes
Whitacre K, Seifer D, Friedman C, Coskun S, Kennard E, Kim M, Alak B. Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes. Fertility And Sterility 1998, 70: 1015-1021. PMID: 9848288, DOI: 10.1016/s0015-0282(98)00339-2.Peer-Reviewed Original ResearchConceptsGerminal vesicle breakdownOvarian sourceNuclear maturationPatient ageGynecologic surgeryFollicular phaseLuteal phaseImmature human oocytesFinal meiotic maturationMenstrual cycle phaseYears of agePercentage of oocytesCycle phaseMetaphase II stageIVF programMenstrual cyclePatient criteriaMAIN OUTCOMEVitro maturationPatientsHuman oocytesOocyte maturationMII stageOocyte's abilityVesicle breakdownActivin a stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro
Alak B, Coskun S, Friedman C, Kennard E, Kim M, Seifer D. Activin a stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro. Fertility And Sterility 1998, 70: 1126-1130. PMID: 9848305, DOI: 10.1016/s0015-0282(98)00386-0.Peer-Reviewed Original ResearchConceptsGranulosa cell steroidogenesisGerminal vesicle breakdownGranulosa cellsActivin AE2 secretionSteroid secretionCell steroidogenesisNonluteinized granulosa cellsMeiotic maturationMetaphase IIUniversity Medical CenterAntral granulosa cellsNonovarian pathologyInhibin AMedical CenterMAIN OUTCOMEActivin A.Oocyte meiotic maturationImmature oocytesHuman oocytesOocyte maturationSecretionVesicle breakdownProgesteroneSteroidogenesis