2011
Changes in plasma müllerian-inhibiting substance and brain-derived neurotrophic factor after chemotherapy in premenopausal women
Aslam MF, Merhi ZO, Ahmed S, Kuzbari O, Seifer DB, Minkoff H. Changes in plasma müllerian-inhibiting substance and brain-derived neurotrophic factor after chemotherapy in premenopausal women. Fertility And Sterility 2011, 95: 1790-1793. PMID: 21075370, PMCID: PMC3047594, DOI: 10.1016/j.fertnstert.2010.10.033.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorPremenopausal womenNeurotrophic factorMüllerian-inhibiting substanceBDNF levelsChemotherapyWomenCancerBloodMonths
2007
Serum müllerian-inhibiting substance in Down's syndrome pregnancies
Seifer DB, MacLaughlin DT, Cuckle HS. Serum müllerian-inhibiting substance in Down's syndrome pregnancies. Human Reproduction 2007, 22: 1017-1020. PMID: 17218369, DOI: 10.1093/humrep/del497.Peer-Reviewed Original ResearchConceptsDown syndrome pregnanciesMüllerian-inhibiting substanceSyndrome pregnanciesUnaffected pregnanciesPregnancy-associated plasma proteinMI levelsMaternal serum levelsSerum MIS levelsWeeks of gestationCase-control studyAntenatal screening programmeAssisted reproduction techniquesMedian valueSerum levelsMIS levelsMaternal ageScreening programPregnancyDown syndromeUnaffected controlsReproduction techniquesSignificant correlationSyndromePlasma proteinsSerum
2004
Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol
Hazout A, Bouchard P, Seifer DB, Aussage P, Junca AM, Cohen-Bacrie P. Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol. Fertility And Sterility 2004, 82: 1323-1329. PMID: 15533354, DOI: 10.1016/j.fertnstert.2004.03.061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersEstradiolFemaleFertilization in VitroFollicle Stimulating HormoneGlycoproteinsHumansInhibinsMultivariate AnalysisOsmolar ConcentrationOvulation InductionPredictive Value of TestsPregnancyPregnancy RateRetrospective StudiesTesticular HormonesTime FactorsTreatment OutcomeConceptsReproductive technology outcomesMullerian-inhibiting substanceYears of ageMultivariate regression analysisInhibin BPregnancy outcomesIVF outcomesAntimullerian hormoneHigher clinical pregnancy rateSerum samplesAvailable serum markersDay 3 FSHSerum antimullerian hormoneClinical pregnancy rateClinical pregnancy outcomesInhibin B levelsFollicle-stimulating hormoneConsecutive serum samplesMüllerian-inhibiting substanceGreater prognostic valueTechnology outcomesRegression analysisClinical pregnancyOvarian stimulationOvulation induction
2003
In vitro fertilization in the older patient.
Derman SG, Seifer DB. In vitro fertilization in the older patient. Current Women'S Health Reports 2003, 3: 375-83. PMID: 12959695.Peer-Reviewed Original ResearchConceptsOlder patientsClomiphene citrate challenge testBasal follicle-stimulating hormoneAntral follicle countDiminished ovarian reserveLower oocyte yieldFollicle-stimulating hormoneHigher miscarriage rateMüllerian-inhibiting substanceHigher cancellation rateIVF success ratesLower pregnancy ratesFlare protocolInhibin BIVF patientsMiscarriage rateOvarian reserveOvarian volumeFollicle countGnRH antagonistOocyte yieldEstradiol levelsPregnancy rateAgonist doseStimulation protocol
1993
Gonadotropin-releasing hormone agonist-induced differences in granulosa cell cycle kinetics are associated with alterations in follicular fluid müllerian-inhibiting substance and androgen content
Seifer DB, MacLaughlin DT, Penzias AS, Behrman HR, Asmundson L, Donahoe PK, Haning RV, Flynn SD. Gonadotropin-releasing hormone agonist-induced differences in granulosa cell cycle kinetics are associated with alterations in follicular fluid müllerian-inhibiting substance and androgen content. The Journal Of Clinical Endocrinology & Metabolism 1993, 76: 711-714. PMID: 8445031, DOI: 10.1210/jcem.76.3.8445031.Peer-Reviewed Original ResearchConceptsHuman menopausal gonadotropinCell cycle kineticsProliferative indexGranulosa cellsFollicular fluidControl groupCycle kineticsGnRH analogue leuprolideOvulation induction regimensFollicular fluid contentMüllerian-inhibiting substanceHuman granulosa cellsLuteinized granulosa cellsCI (3.2-3.6) PInduction regimensMenopausal gonadotropinOocyte retrievalAndrogen contentGnRHSpecific growth factorsFlow cytometryGrowth factorFolliclesFluid contentOne-way analysis