2024
Assessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates
Wang S, Seifer D. Assessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates. Obstetrics And Gynecology 2024, 143: 839-848. PMID: 38696814, DOI: 10.1097/aog.0000000000005598.Peer-Reviewed Original ResearchConceptsCumulative live birth rateLive birth rateAssisted reproductive technologyPreimplantation genetic testingInfertility diagnosisLive birthsOvulatory disordersGenetic testingReproductive technologyOdds of live birthMale factor infertilityFrozen embryo transferDiminished ovarian reserveClinical practiceRetrospective cohort studyAssociated with decreased oddsSART CORS databaseField of assisted reproductive technologyDemographic shiftsSART CORSOvarian reserveInfertility causeEmbryo transferCounseling patientsCohort studyAge-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT
Wang S, Seifer D. Age-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT. Reproductive Biology And Endocrinology 2024, 22: 42. PMID: 38615016, PMCID: PMC11015537, DOI: 10.1186/s12958-024-01210-0.Peer-Reviewed Original ResearchConceptsFrozen-thawed embryo transferCumulative live birth rateLive birth rateDiminished ovarian reservePreimplantation genetic testingMultivariate logistic regressionFresh transferLive birth outcomesLive birthsEmbryo transferAssisted reproductive technologyART cyclesEndometrial receptivityBirth outcomesFrozen-thawed embryo transfer cyclesOdds of live birthAssisted reproductive technology cyclesChance of live birthFresh embryo transferFrozen-thawed cyclesFrozen-thawed embryosMale factor infertilityRetrospective cohort studyEmbryo transfer methodsAge groups
2021
AMH Highly Correlates With Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve Independent of Age*
Tal R, Seifer DB, Tal R, Granger E, Wantman E, Tal O. AMH Highly Correlates With Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve Independent of Age*. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: 2754-2766. PMID: 33729496, DOI: 10.1210/clinem/dgab168.Peer-Reviewed Original ResearchConceptsCumulative live birth rateDiminished ovarian reserveLive birth rateSerum AMHLive birthsAge strataRetrieval cycleAntimüllerian hormone levelsReproductive technology cyclesCumulative live birthMain outcome measuresMultiple logistic regressionNumber of oocytesBirth rateRegression analysisPreimplantation genetic testingAddition of AMHPercentage of cyclesOvarian reserveIndependent predictorsOvarian responseHormone levelsRetrospective analysisOutcome measuresEmbryo transfer
2015
Prognostic indicators of assisted reproduction technology outcomes of cycles with ultralow serum antimüllerian hormone: a multivariate analysis of over 5,000 autologous cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013
Seifer DB, Tal O, Wantman E, Edul P, Baker VL. Prognostic indicators of assisted reproduction technology outcomes of cycles with ultralow serum antimüllerian hormone: a multivariate analysis of over 5,000 autologous cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013. Fertility And Sterility 2015, 105: 385-393.e3. PMID: 26515380, DOI: 10.1016/j.fertnstert.2015.10.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersCryopreservationDatabases, FactualEmbryo TransferFemaleFertilityFertilization in VitroHumansInfertilityLinear ModelsLive BirthLogistic ModelsMiddle AgedMultivariate AnalysisOocyte RetrievalPatient SelectionPregnancyPregnancy RatePregnancy, MultipleReproductive Techniques, AssistedRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeYoung AdultConceptsLive birth rateAntimüllerian hormoneCancellation rateAMH levelsAssisted Reproductive Technology Clinic Outcome Reporting System databaseAssisted reproduction technology (ART) outcomesEmbryo cryopreservation ratesSerum antimüllerian hormoneTotal cancellation rateMultiple birth ratesReporting System databaseCycle startAutologous cyclesClinical pregnancyCycle cancellationPrognostic factorsAMH valuesFresh cyclesCycle outcomePrognostic indicatorAMH concentrationsRetrospective analysisMAIN OUTCOMEEmbryo transferMultivariate analysis
2014
Successful Same‐Cycle Blastocyst Transfer following Laparoscopic Ovarian Detorsion: A Report of Two Cases and Literature Review
Irani M, Tal R, Seifer DB, Grazi RV. Successful Same‐Cycle Blastocyst Transfer following Laparoscopic Ovarian Detorsion: A Report of Two Cases and Literature Review. Case Reports In Obstetrics And Gynecology 2014, 2014: 806378. PMID: 24864219, PMCID: PMC4020476, DOI: 10.1155/2014/806378.Peer-Reviewed Original ResearchOvarian torsionEmbryo transferOocyte retrievalFavorable pregnancy outcomeLaparoscopic ovarian detorsionOvarian detorsionLaparoscopic evaluationOvarian stimulationPregnancy outcomesFertilization cyclesInfertility patientsPregnancy chancesSuccessful pregnancyBlastocyst transferEgg retrievalClinical dilemmaOptimal timingDetorsionPatientsConcurrent cyclesSuch casesLiterature reviewPregnancyIVFCasesAssociation of Anti-Mullerian Hormone (AMH) Level and Pregnancy Outcome in Day 5 Elective Single Embryo Transfer
Lin W, Seifer D, Missmer S, Hornstein M. Association of Anti-Mullerian Hormone (AMH) Level and Pregnancy Outcome in Day 5 Elective Single Embryo Transfer. Fertility And Sterility 2014, 101: e34. DOI: 10.1016/j.fertnstert.2013.11.121.Peer-Reviewed Original Research
2013
Report of two cases of ovarian torsion after egg retrieval treated by laparoscopic detorsion followed by successful embryo transfer on day five
Irani M, Tal R, Seifer D, Grazi R. Report of two cases of ovarian torsion after egg retrieval treated by laparoscopic detorsion followed by successful embryo transfer on day five. Fertility And Sterility 2013, 100: s285-s286. DOI: 10.1016/j.fertnstert.2013.07.1068.Peer-Reviewed Original Research
2004
Impact of retained embryos on the outcome of assisted reproductive technologies
Lee HC, Seifer DB, Shelden RM. Impact of retained embryos on the outcome of assisted reproductive technologies. Fertility And Sterility 2004, 82: 334-337. PMID: 15302280, DOI: 10.1016/j.fertnstert.2004.01.035.Peer-Reviewed Original ResearchConceptsEmbryo transfer cyclesPregnancy outcomesEmbryo transferTransfer cyclesTransfer catheterInitial embryo transferEmbryo transfer catheterAssisted reproductive technology practiceRetained embryosOocyte retrievalImplantation rateDelivery ratePregnancy rateRetrospective analysisMAIN OUTCOMEReproductive technology practiceEmbryo cyclesUse of ultrasoundCatheterAdverse effectsFertilization programFrozen embryosReproductive technologiesOutcomesEmbryo retention
2001
Contribution of diminished ovarian reserve to hypofertility associated with endometriosis.
Hock DL, Sharafi K, Dagostino L, Kemmann E, Seifer DB. Contribution of diminished ovarian reserve to hypofertility associated with endometriosis. The Journal Of Reproductive Medicine 2001, 46: 7-10. PMID: 11209637.Peer-Reviewed Original ResearchConceptsStage III/IV endometriosisStage I/II endometriosisOvarian reserveFSH levelsFertilization/embryo transferHigh E2 levelsStage of endometriosisDay 3 levelsMale factor infertilityCase-control studyAge-matched controlsFactor infertilityE2 levelsEndometriosisEmbryo transferTotal groupProgressive lossControl levelsWomenSignificant differencesE2FSHLevelsPatientsInfertility
1998
Predicting Probabilities of Pregnancy and Multiple Gestation From In Vitro Fertilization—A New Model
WHEELER C, COLE B, FRISHMAN G, SEIFER D, LOVEGREEN S, HACKETT R. Predicting Probabilities of Pregnancy and Multiple Gestation From In Vitro Fertilization—A New Model. Obstetrics And Gynecology 1998, 91: 696-700. DOI: 10.1097/00006250-199805000-00010.Peer-Reviewed Original ResearchConceptsMultiple gestationsProbability of pregnancyEmbryo scoreNumber of embryosThird implantationFertilization cyclesInfant HospitalIVF programVitro FertilizationEmbryo transferPregnancySecond implantationLogistic regressionPatient-specific informationGestationP2/P1Embryo scoringHospitalScoresAgeImplantationBest predictorP3/P2PatientsPredicting probabilities of pregnancy and multiple gestation from in vitro fertilization--a new model.
Wheeler C, Cole B, Frishman G, Seifer D, Lovegreen S, Hackett R. Predicting probabilities of pregnancy and multiple gestation from in vitro fertilization--a new model. Obstetrics And Gynecology 1998, 91: 696-700. PMID: 9572213, DOI: 10.1016/s0029-7844(98)00008-8.Peer-Reviewed Original ResearchConceptsIn vitro fertilizationEmbryo scoreMultiple gestationsProbability of pregnancyIn vitro fertilization programDistribution of pregnanciesEmbryo transferInfant hospitalizationPregnancyGestationIncreasing ageLogistic regressionPatient-specific informationScoresImplantationEmbryosPredicted probabilityAgePatientsInfants
1995
Endocrinology: Follicular fluid insulin-like growth factor-I and insulin-like growth factor-II concentrations vary as a function of day 3 serum follicle stimulating hormone*
Seifer DB, Giudice LC, Dsupin BA, Haning RV, Frishman GN, Burger HG. Endocrinology: Follicular fluid insulin-like growth factor-I and insulin-like growth factor-II concentrations vary as a function of day 3 serum follicle stimulating hormone*. Human Reproduction 1995, 10: 804-806. PMID: 7650124, DOI: 10.1093/oxfordjournals.humrep.a136042.Peer-Reviewed Original ResearchConceptsDay 3 serum follicleInsulin-like growth factorFollicular fluid concentrationsFSH groupSerum follicleIGF-IIGrowth factorFollicular fluid insulin-like growth factorMean IGF-II concentrationsFluid concentrationsMean IGF-I concentrationInsulin-like growth factor II concentrationsDay 3 FSHFollicular fluid IGFIGF-II concentrationsIGF-I concentrationsFactor II concentrationsFollicular fluid aspirationInhibin concentrationsFluid aspirationEmbryo transferFolliclesIGFHormoneGroup