2018
Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis
Raftogianni A, Roth LC, García-González D, Bus T, Kühne C, Monyer H, Spergel DJ, Deussing JM, Grinevich V. Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis. Frontiers In Molecular Neuroscience 2018, 11: 305. PMID: 30214395, PMCID: PMC6125327, DOI: 10.3389/fnmol.2018.00305.Peer-Reviewed Original ResearchCRH receptor type 1Corticotropin-releasing hormoneHPG axisCentral neuronsCRH receptorsPharmacological studiesAcute stressGonadotropin-releasing hormone (GnRH) neuronsMale HPG axisDecrease of plasmaEarlier pharmacological studiesReceptor type 1Stress induced inhibitionHormone neuronsLH releaseGABAergic neuronsCentral infusionPituitary levelMale miceGonadal axisReproductive axisImmunological stressType 2Pituitary culturesBasal conditions
2005
Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons.
Shimshek DR, Bus T, Grinevich V, Single FN, Mack V, Sprengel R, Spergel DJ, Seeburg PH. Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons. Endocrinology 2005, 20: 219-31. PMID: 16099814, DOI: 10.1210/me.2005-0262.Peer-Reviewed Original ResearchConceptsAMPA receptorsNMDA receptorsGnRH secretionMale miceN-methyl-D-aspartate receptorsLimbic system neuronsSerum testosterone levelsIsoxazolepropionic acid (AMPA) receptorsIonotropic glutamate receptorsNormal litter sizeMale sexual behaviorGnRH neuronsSeptal neuronsSystem neuronsOvarian morphologyGlutamate receptorsSeptal areaTestosterone levelsControl littermatesMale littermatesPup retrievalMajor subtypesTestis weightMaternal aggressionAcid receptors