2019
Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans
Gelernter J, Sun N, Polimanti R, Pietrzak R, Levey DF, Bryois J, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Pyarajan S, Sullivan PF, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Concato J, Zhao H, Stein MB. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans. Nature Neuroscience 2019, 22: 1394-1401. PMID: 31358989, PMCID: PMC6953633, DOI: 10.1038/s41593-019-0447-7.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesHigh linkage disequilibrium regionLinkage disequilibrium regionWide association studyDisequilibrium regionBioinformatics analysisTranscriptomic profilesMillion Veteran ProgramChromosome 17Genetic risk factorsNew insightsUK Biobank dataReexperiencing of traumaStriatal medium spiny neuronsVeteran ProgramSignificant regionsCAMKVEuropean AmericansBiobank dataMedium spiny neuronsTCF4BiologyKANSL1African American cohort
2016
Mood, stress and longevity: convergence on ANK3
Rangaraju S, Levey DF, Nho K, Jain N, Andrews KD, Le-Niculescu H, Salomon DR, Saykin AJ, Petrascheck M, Niculescu AB. Mood, stress and longevity: convergence on ANK3. Molecular Psychiatry 2016, 21: 1037-1049. PMID: 27217151, PMCID: PMC9798616, DOI: 10.1038/mp.2016.65.Peer-Reviewed Original ResearchConceptsSignificant single nucleotide polymorphismsC. elegansGenome-wide association study approachLongevity/agingFunctional genomics approachConvergent functional genomics approachOrthologs of genesOxidative stress resistanceCorresponding human orthologsHutchinson-Gilford progeria syndromeSeries of genesTop candidate genesGene expression studiesOlder wormsUnbiased drug screenANK3 expressionGenomic approachesAntagonistic pleiotropyGene expression biomarkersHuman orthologLow expression levelsStress resistanceSingle nucleotide polymorphismsBioinformatics analysisTop genes