2020
TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry
Xie J, Heim EN, Crite M, DiMaio D. TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry. Cell Reports 2020, 31: 107750. PMID: 32521275, PMCID: PMC7339955, DOI: 10.1016/j.celrep.2020.107750.Peer-Reviewed Original ResearchConceptsGTPase-activating proteinsRetrograde transport pathwayVirus entryRetromer activityHPV traffickingTrafficking complexMembrane recruitmentRetromer complexRab7-GTPCellular proteinsCellular compartmentsEndosome membraneRetromerRetrograde pathwayArtificial proteinsL2 capsid proteinsCapsid proteinRab7HPV entryTraffickingTBC1D5ProteinGTPTransport pathwaysPathway
2001
Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres.
Goodwin E, DiMaio D. Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres. Molecular Cancer Research 2001, 12: 525-34. PMID: 11714633.Peer-Reviewed Original ResearchConceptsTumor suppressor pathwayHeLa cervical carcinoma cellsExtended telomeresReplicative senescenceHTERT geneSuppressor pathwayTelomerase activityGrowth arrestCervical carcinoma cellsRepression of telomeraseElevated telomerase activitySomatic human cellsNormal somatic human cellsShort telomeresGrowth-arrested stateSenescence-associated beta-galactosidase expressionHPV E6/E7 expressionGrowth-arrested cellsHeLa cell clonesProfound growth arrestRole of telomeraseE6/E7 genesBeta-galactosidase expressionErosion of telomeresCarcinoma cells
1992
Localization of bovine papillomavirus type 1 E5 protein to transformed basal keratinocytes and permissive differentiated cells in fibropapilloma tissue.
Burnett S, Jareborg N, DiMaio D. Localization of bovine papillomavirus type 1 E5 protein to transformed basal keratinocytes and permissive differentiated cells in fibropapilloma tissue. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 5665-5669. PMID: 1319069, PMCID: PMC49353, DOI: 10.1073/pnas.89.12.5665.Peer-Reviewed Original Research
1991
Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16
Leptak C, Cajal S, Kulke R, Horwitz B, Riese D, Dotto G, DiMaio D. Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16. Journal Of Virology 1991, 65: 7078-7083. PMID: 1658398, PMCID: PMC250837, DOI: 10.1128/jvi.65.12.7078-7083.1991.Peer-Reviewed Original ResearchConceptsBovine papillomavirus type 1E5 genePapillomavirus type 1Human Papillomavirus Type 16 E5 GeneTumorigenic transformationHost epithelial cellsExpression vectorRecombinant virusesRetroviral expression vectorMurine keratinocytesBiological propertiesTumorigenic cellsMurine epidermal keratinocytesGenesMurine fibroblastsFrameshift mutationCultured linesHuman papillomavirus type 16Cell linesEpithelial cellsPapillomavirus type 16Epidermal keratinocytesRetrovirusesCellsKeratinocytes
1990
Integrated HPV 1 genomes in a human keratinocyte cell line can be transactivated by a SV40/BPV1 recombinant virus which expresses BPV1 E2 proteins
Partow A, Grand R, Biggs P, Jeffrey S, Dimaio D, Gallimore P. Integrated HPV 1 genomes in a human keratinocyte cell line can be transactivated by a SV40/BPV1 recombinant virus which expresses BPV1 E2 proteins. Virology 1990, 175: 508-517. PMID: 2158183, DOI: 10.1016/0042-6822(90)90435-t.Peer-Reviewed Original ResearchCell Line, TransformedClone CellsDNA, RecombinantDNA, ViralDNA-Binding ProteinsGene Expression Regulation, ViralHumansKaryotypingKeratinocytesNucleic Acid HybridizationPapillomaviridaePolymerase Chain ReactionRecombinant ProteinsRNA SplicingSimian virus 40Transcription, GeneticTranscriptional ActivationTransfectionViral Proteins
1989
Bovine Papillomavirus Type I Induces Resistance to Ca++-Induced Terminal Differentiation in Murine Keratinocytes
Reiss M, DiMaio D, Zibello T. Bovine Papillomavirus Type I Induces Resistance to Ca++-Induced Terminal Differentiation in Murine Keratinocytes. Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 1989, 1: 75-82. PMID: 2561735, DOI: 10.3727/095535489820875318.Peer-Reviewed Original Research