2021
Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III)
Goel R, Nellis ME, Karam O, Hanson SJ, Tormey CA, Patel RM, Birch R, Sachais BS, Sola‐Visner M, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Study‐IV‐Pediatric F. Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III). Transfusion 2021, 61: 2589-2600. PMID: 34455598, DOI: 10.1111/trf.16626.Peer-Reviewed Original ResearchConceptsInternational normalized ratioBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIINational Heart LungTransfusion practicePediatric oncologyRecipient EpidemiologyHSCT patientsPlasma transfusionRed blood cellsPlatelet countHeart LungHematopoietic stem cell transplantation patientsHematopoietic stem cell transplant patientsMedian international normalized ratioStem cell transplant patientsStem cell transplantation patientsLower INR valuesPre-transfusion HbMedian platelet countMulticenter retrospective studyCell transplant patientsCell transplantation patientsStudy IIIAcute myeloid leukemia
2020
Investigation of increased platelet alloimmunization screening in the era of pathogen‐reduced platelets treated with psoralen/UV light
Hendrickson JE, Mendoza H, Ross R, Siddon AJ, Gowda L, Hauser RG, Schulz WL, Tormey CA. Investigation of increased platelet alloimmunization screening in the era of pathogen‐reduced platelets treated with psoralen/UV light. Transfusion 2020, 60: 650-651. PMID: 32128834, DOI: 10.1111/trf.15691.Peer-Reviewed Original ResearchPassive anti‐C acquired in the setting of Rh immune globulin administration following Rh mismatched apheresis platelet transfusion: A case series
Sostin N, Ross R, Balbuena‐Merle R, Hendrickson JE, Tormey CA. Passive anti‐C acquired in the setting of Rh immune globulin administration following Rh mismatched apheresis platelet transfusion: A case series. Journal Of Clinical Apheresis 2020, 35: 224-226. PMID: 32110829, DOI: 10.1002/jca.21773.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsRh immune globulin administrationRisk/benefit ratioApheresis platelet transfusionImmune globulin administrationRhIG immunoprophylaxisImmune globulinTransfusion supportAlloantibody formationCase seriesNegative recipientsAlloimmunization riskRhIG administrationReproductive agePassive transferPLT transfusionsTransfusionBlood bankBenefit ratioRhIGApheresis PLTsAdministrationImmunoprophylaxisPatientsSetting
2019
Transfusion Medicine Equations Made Internet Accessible
Hauser RG, Kwon RJ, Ryder A, Cheng C, Charifa A, Tormey C. Transfusion Medicine Equations Made Internet Accessible. Transfusion Medicine Reviews 2019, 34: 5-9. PMID: 31785949, DOI: 10.1016/j.tmrv.2019.10.003.Peer-Reviewed Original ResearchFatal acute hemolytic transfusion reaction due to anti‐B from a platelet apheresis unit stored in platelet additive solution
Balbuena‐Merle R, West FB, Tormey CA, Hendrickson JE. Fatal acute hemolytic transfusion reaction due to anti‐B from a platelet apheresis unit stored in platelet additive solution. Transfusion 2019, 59: 1911-1915. PMID: 30865314, DOI: 10.1111/trf.15240.Peer-Reviewed Original ResearchConceptsGroup B patientsHemolytic transfusion reactionsDirect antiglobulin testB patientsTransfusion reactionsApheresis unitsBlood group B patientsRelapsed acute myeloid leukemiaAcute hemolytic transfusion reactionAnti-human globulin phaseHigh lactate dehydrogenaseAnti-human globulinAcute myeloid leukemiaRecipient testingDonor testingRecipient variablesExtravascular hemolysisPlatelet transfusionsTransfusion recipientsAntibody screenHigh bilirubinPLT transfusionsAntiglobulin testBlood productsMyeloid leukemia
2018
Transfused platelets enhance alloimmune responses to transfused KEL-expressing red blood cells in a murine model.
Madrid DJ, Santhanakrishnan M, Liu J, Gibb DR, Liu D, Natarajan P, Beitler D, Shi Z, Mo C, Tormey CA, Patel SR, Stowell SR, Hendrickson JE. Transfused platelets enhance alloimmune responses to transfused KEL-expressing red blood cells in a murine model. Blood Transfusion 2018, 17: 368-377. PMID: 30418129, PMCID: PMC6774925, DOI: 10.2450/2018.0178-18.Peer-Reviewed Original ResearchConceptsRed blood cell transfusionBlood cell transfusionTransfusion of plateletsAlloimmune responseRed blood cellsCell transfusionWild-type recipientsBlood cellsImmune responseMurine modelRed blood cell alloimmunisationCD40/CD40L interactionHuman KEL glycoproteinWild-type C57BL/6Humoral immune responseAdaptive immune responsesDevelopment of alloantibodiesPlatelet-rich plasmaEndogenous plateletsCD40L interactionRecipient treatmentTransfusionDanger signalsCD40LTransgenic donorsVery low rate of anti‐D development in male, primarily immunocompetent patients transfused with D‐mismatched platelets
Curtis G, Scott M, Orengo L, Hendrickson JE, Tormey CA. Very low rate of anti‐D development in male, primarily immunocompetent patients transfused with D‐mismatched platelets. Transfusion 2018, 58: 1568-1569. PMID: 29949189, DOI: 10.1111/trf.14614.Peer-Reviewed Original ResearchMeSH KeywordsBlood Component RemovalBlood PlateletsHumansMalePlatelet TransfusionProspective StudiesRho(D) Immune Globulin
2016
CD8+ T cells mediate antibody-independent platelet clearance in mice
Arthur CM, Patel SR, Sullivan HC, Winkler AM, Tormey CA, Hendrickson JE, Stowell SR. CD8+ T cells mediate antibody-independent platelet clearance in mice. Blood 2016, 127: 1823-1827. PMID: 26787734, PMCID: PMC4825415, DOI: 10.1182/blood-2015-10-673426.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PlateletsCD8-Positive T-LymphocytesHumansIsoantibodiesMicePlatelet TransfusionConceptsPlatelet clearancePlatelet removalImportant therapeutic interventionPlatelet transfusionsNonimmune mechanismsT cellsTherapeutic outcomesAlloantibodiesTherapeutic interventionsAppropriate managementTransfusionClearanceSole mediatorPatientsVariety of mechanismsComplete absenceNumerous studiesCD8Clear mechanismCellsAbsenceMiceIndividualsPrevention
2014
Use of a Cytokine-Release Assay to Demonstrate Loss of Platelet Secretory Capacity During Blood Bank Processing and Storage
Tormey CA, Stack G. Use of a Cytokine-Release Assay to Demonstrate Loss of Platelet Secretory Capacity During Blood Bank Processing and Storage. Archives Of Pathology & Laboratory Medicine 2014, 138: 1481-7. PMID: 25357109, DOI: 10.5858/arpa.2013-0680-oa.Peer-Reviewed Original ResearchThe Development and Implementation of, and First Years' Experience With, a Massive/Emergency Transfusion Protocol (Damage Control Hematology Protocol) in a Veterans Affairs Hospital
Gehrie EA, Tormey CA. The Development and Implementation of, and First Years' Experience With, a Massive/Emergency Transfusion Protocol (Damage Control Hematology Protocol) in a Veterans Affairs Hospital. Military Medicine 2014, 179: 1099-1105. PMID: 25269127, DOI: 10.7205/milmed-d-14-00045.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBlood BanksBlood Grouping and CrossmatchingBlood Loss, SurgicalBlood TransfusionClinical AuditClinical ProtocolsConnecticutEmergenciesErythrocyte TransfusionFactor VIIaFactor VIIIFibrinogenHematemesisHospitals, VeteransHumansLaboratories, HospitalMalePlasma ExchangePlatelet TransfusionPostoperative HemorrhageRetrospective StudiesUnited StatesUnited States Department of Veterans AffairsConceptsFresh frozen plasmaRecombinant factor VIIaRed blood cellsVeterans Affairs hospitalTransfusion protocolFactor VIIaUnits of RBCsVeterans Affairs Connecticut Healthcare SystemUnits of FFPLarge trauma centersHospital-based blood banksETP patientsMassive transfusionTrauma centerFrozen plasmaSeparate patientsPatientsWest HavenBleeding emergenciesBlood bankBlood cellsYears' experienceHealthcare systemPlateletsHospital
2013
Allergic transfusion reactions to platelets are more commonly associated with prepooled than apheresis components
Xiao W, Tormey CA, Capetillo A, Maitta RW. Allergic transfusion reactions to platelets are more commonly associated with prepooled than apheresis components. Vox Sanguinis 2013, 105: 334-340. PMID: 23802769, DOI: 10.1111/vox.12063.Peer-Reviewed Original ResearchConceptsAllergic transfusion reactionsTransfusion reactionsATR rateApheresis plateletsPlatelet componentsApheresis componentsAcademic medical centerABO mismatchAdverse eventsAntigen exposurePlatelet transfusionsPlatelet countDonor factorsMedical CenterApheresis productsApheresis unitsPlatelet productsStudy periodTransfusionPlateletsSimilar ratesFurther investigation
2010
In vitro and in vivo evaluation of a whole blood platelet‐sparing leukoreduction filtration system
Snyder EL, Whitley P, Kingsbury T, Miripol J, Tormey CA. In vitro and in vivo evaluation of a whole blood platelet‐sparing leukoreduction filtration system. Transfusion 2010, 50: 2145-2151. PMID: 20497514, DOI: 10.1111/j.1537-2995.2010.02701.x.Peer-Reviewed Original ResearchMeSH KeywordsBlood DonorsBlood PreservationErythrocytesHumansLeukocyte Reduction ProceduresLeukocytesPlasmaPlatelet TransfusionConceptsRed blood cellsWhite blood cellsAutologous plateletsTransfusion productsBlood cellsAdverse clinical sequelaeCPD plasmaProduction of plateletsResidual white blood cellsClinical sequelaeDrug Administration requirementsHospital useVivo efficacyLeukoreduction filtersBlood centersStudy designVivo evaluationLR productsVivo characteristicsPlateletsRBC recoveryAdministration requirementsVitroSurvival ratioFDA guidelines
2009
Platelet-Related Bleeding: An Update on Diagnostic Modalities and Therapeutic Options
Peddinghaus ME, Tormey CA. Platelet-Related Bleeding: An Update on Diagnostic Modalities and Therapeutic Options. Clinics In Laboratory Medicine 2009, 29: 175-191. PMID: 19665674, DOI: 10.1016/j.cll.2009.03.004.Peer-Reviewed Original ResearchMeSH KeywordsBlood Platelet DisordersHumansPlatelet AdhesivenessPlatelet AggregationPlatelet Function TestsPlatelet TransfusionConceptsPlatelet function testingFunction testingCare platelet function testingChronic clinical settingsPlatelet-related bleedingLife-threatening problemTransfusion strategyPlatelet dysfunctionTherapeutic optionsComponent therapyDiagnostic modalitiesClinical settingBleedingPatientsInitial studyLaboratory assaysTransfusionDysfunctionTherapyCareAnalysis of transfusion reactions associated with prestorage‐pooled platelet components
Tormey CA, Sweeney JD, Champion MH, Pisciotto PT, Snyder EL, Wu Y. Analysis of transfusion reactions associated with prestorage‐pooled platelet components. Transfusion 2009, 49: 1242-1247. PMID: 19389029, DOI: 10.1111/j.1537-2995.2009.02128.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlood PreservationChildChild, PreschoolFemaleHumansMaleMiddle AgedPlatelet TransfusionRetrospective StudiesConceptsRandom donor plateletsSingle-donor plateletsTransfusion reactionsPlatelet infusionTransfusion-related acute lung injuryCommon adverse eventsPLT productsAcute lung injuryTertiary care hospitalCases of sepsisAllergic transfusion reactionsTransfusion reaction ratesSignificant differencesAdverse eventsLung injuryCare hospitalVolume overloadFebrile reactionsChi-square analysisTotal infusionPlatelet componentsInfusionStudy designP-valuePlatelets