2016
Understanding red blood cell alloimmunization triggers
Hendrickson JE, Tormey CA. Understanding red blood cell alloimmunization triggers. Hematology 2016, 2016: 446-451. PMID: 27913514, PMCID: PMC6142457, DOI: 10.1182/asheducation-2016.1.446.Peer-Reviewed Original ResearchConceptsRBC alloimmunizationRed blood cellsRisk factorsBlood cellsWhite blood cellsBlood group antigensPregnancy outcomesAlloantibody formationRBC alloantibodiesRBC transfusionRecipient factorsTransfusion safetyAlloimmunizationAnimal modelsHuman studiesPrevention strategiesDonor plasmaDanger signalsParticular antigenGroup antigensAntigenTransfusionPregnancyNonrespondersCellsThe Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice
Gibb DR, Calabro S, Liu D, Tormey CA, Spitalnik SL, Zimring JC, Hendrickson JE, Hod EA, Eisenbarth SC. The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice. EBioMedicine 2016, 9: 77-86. PMID: 27345021, PMCID: PMC4972549, DOI: 10.1016/j.ebiom.2016.06.008.Peer-Reviewed Original ResearchConceptsRBC transfusionNLRP3 inflammasomeRed blood cell transfusionInnate immune cell activationPro-inflammatory pathogensMolecular patternsBlood cell transfusionProduction of alloantibodiesTransfusion-associated mortalityImmune cell activationInnate immune stimuliBlood group antigensBone marrow failureAlloantibody productionRBC alloimmunizationAlloantibody responsesCell transfusionAlloimmune responseRed blood cellsABO matchingImmunological factorsInflammatory conditionsLeading causeImmune stimuliEndogenous DAMPRed Blood Cell Antibodies in Hematology/Oncology Patients Interpretation of Immunohematologic Tests and Clinical Significance of Detected Antibodies
Hendrickson JE, Tormey CA. Red Blood Cell Antibodies in Hematology/Oncology Patients Interpretation of Immunohematologic Tests and Clinical Significance of Detected Antibodies. Hematology/Oncology Clinics Of North America 2016, 30: 635-651. PMID: 27113001, DOI: 10.1016/j.hoc.2016.01.006.Peer-Reviewed Original ResearchConceptsRed blood cell transfusionRed blood cell antibodiesRBC alloimmunization rateBlood cell transfusionManagement of patientsDevelopment of alloantibodiesBlood group antigensAlloimmunization rateRBC alloimmunizationSuch alloantibodiesCell transfusionCell antibodiesClinical significanceHemolytic anemiaPatients' interpretationsDetected antibodiesTransfusionGroup antigensBlood bankCompatible unitsAntibodiesAlloantibodiesOncology disordersDeleterious consequencesAlloimmunization
2015
Routine non‐ABO blood group antigen genotyping in sickle cell disease: the new frontier in pretransfusion testing?
Tormey CA, Hendrickson JE. Routine non‐ABO blood group antigen genotyping in sickle cell disease: the new frontier in pretransfusion testing? Transfusion 2015, 55: 1374-1377. PMID: 26094720, DOI: 10.1111/trf.13065.Peer-Reviewed Original Research
2014
The Influence of Clinical and Biological Factors on Transfusion-Associated Non-ABO Antigen Alloimmunization: Responders, Hyper-Responders, and Non-Responders
Gehrie EA, Tormey CA. The Influence of Clinical and Biological Factors on Transfusion-Associated Non-ABO Antigen Alloimmunization: Responders, Hyper-Responders, and Non-Responders. Transfusion Medicine And Hemotherapy 2014, 41: 420-429. PMID: 25670929, PMCID: PMC4280450, DOI: 10.1159/000369109.Peer-Reviewed Original ResearchRed blood cellsPatient populationInfluence of ClinicalDevelopment of antibodiesImportant clinical consequencesDiverse patient populationsBlood group antigensRBC alloimmunizationChronic transfusionRBC alloantibodiesHyper respondersClinical circumstancesClinical consequencesAlloimmunizationMedical literatureTransfusionAlloantibodiesGroup antigensRespondersBlood cellsTransfusion medicinePatientsBiological factorsIndividualsPregnancy
2009
Immunogenicity of blood group antigens: a mathematical model corrected for antibody evanescence with exclusion of naturally occurring and pregnancy-related antibodies
Tormey CA, Stack G. Immunogenicity of blood group antigens: a mathematical model corrected for antibody evanescence with exclusion of naturally occurring and pregnancy-related antibodies. Blood 2009, 114: 4279-4282. PMID: 19713462, DOI: 10.1182/blood-2009-06-227793.Peer-Reviewed Original Research